Edetic acid
Edetate (edetic acid) is a small molecule pharmaceutical. Edetic acid was first approved as Calcium disodium versenate on 1982-01-01. It is used to treat drug overdose, hypercalcemia, and ventricular tachycardia in the USA.
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Commercial
Trade Name
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Edetate (discontinued: Versenate)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Edetate calcium disodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CALCIUM DISODIUM VERSENATE | Bausch Health Companies | N-008922 DISCN | 1982-01-01 | 2 products |
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Brand Name | Status | Last Update |
|---|---|---|
| miin foot | OTC monograph not final | 2019-08-22 |
| miracle footcream lavender | unapproved drug other | 2022-03-28 |
| miracle footcream lemon | unapproved drug other | 2022-03-28 |
| the melanin skin protectant cream | unapproved drug other | 2025-05-01 |
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FDA
EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
EDETATE CALCIUM DISODIUM, EDETATE CALCIUM DISODIUM, CASPER PHARMA LLC | |||
| 2024-01-08 | CGT | ||
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Clinical
Clinical Trials
1028 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 10 | 12 | 3 | 1 | 22 | 44 |
| Bronchiolitis | D001988 | — | — | — | 9 | 8 | 11 | 17 | 42 |
| Fibrosis | D005355 | — | — | 7 | 7 | 1 | 2 | 19 | 33 |
| Postoperative pain | D010149 | — | G89.18 | — | 1 | — | 3 | 29 | 33 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 3 | 3 | 4 | 20 | 31 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | 1 | 2 | — | 1 | 26 | 30 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 2 | 1 | 23 | 26 |
| Healthy volunteers/patients | — | — | — | 7 | 3 | — | 1 | 16 | 25 |
| Dental pulp necrosis | D003790 | — | K04.1 | — | 3 | 1 | 1 | 17 | 21 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | 1 | 1 | 16 | 20 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 4 | 1 | — | 21 | 27 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | 1 | 1 | — | 13 | 15 |
| Infections | D007239 | EFO_0000544 | — | 2 | 3 | 1 | — | 8 | 12 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | 2 | — | 7 | 11 |
| Wounds and injuries | D014947 | — | T14.8 | 3 | 3 | 2 | — | 5 | 11 |
| Brain injuries | D001930 | — | S06.9 | 2 | 4 | 5 | — | 4 | 11 |
| Traumatic brain injuries | D000070642 | — | S06 | 2 | 4 | 6 | — | 3 | 11 |
| Septic shock | D012772 | — | A48.3 | — | — | 1 | — | 9 | 10 |
| Renal insufficiency | D051437 | — | N19 | — | 2 | 1 | — | 7 | 10 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | 1 | — | 7 | 9 |
Show 80 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Circulating neoplastic cells | D009360 | — | — | — | 1 | — | — | 10 | 11 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | 1 | — | — | 10 | 11 |
| Syndrome | D013577 | — | — | — | 1 | — | — | 9 | 10 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 2 | — | — | 7 | 10 |
| Diabetes insipidus | D003919 | — | E23.2 | — | 1 | — | — | 8 | 9 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | 1 | — | — | 7 | 9 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | 1 | — | — | 5 | 8 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 1 | — | — | 5 | 7 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 3 | 3 | — | — | 3 | 7 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | — | — | 6 | 7 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | 7 | 8 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | 4 | 6 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | 4 | 5 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | 4 | 5 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | 3 | 4 |
| Acute lung injury | D055371 | EFO_0004610 | — | 2 | — | — | — | 2 | 4 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 2 | 3 |
| Central nervous system neoplasms | D016543 | — | — | 2 | — | — | — | 1 | 3 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | — | — | — | 2 | 3 |
| Gliosarcoma | D018316 | — | — | 1 | — | — | — | 2 | 3 |
Show 24 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | — | — | — | 9 | 9 |
| Gingival recession | D005889 | — | K06.0 | — | — | — | — | 7 | 7 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 7 | 7 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 6 | 6 |
| Periapical diseases | D010483 | EFO_0010688 | — | — | — | — | — | 6 | 6 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 5 | 5 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 4 | 4 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | — | — | — | 4 | 4 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Bronchitis | D001991 | — | J40 | — | — | — | — | 4 | 4 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Edetic acid |
| INN | edetic acid |
| Description | Ethylenediaminetetraacetic acid is a tetracarboxylic acid, an ethylenediamine derivative and a polyamino carboxylic acid. It has a role as an antidote, a geroprotector, a chelator, a copper chelator and an anticoagulant. It is a conjugate acid of an EDTA(2-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 150-43-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL858 |
| ChEBI ID | 42191 |
| PubChem CID | 6049 |
| DrugBank | DB00974 |
| UNII ID | 9G34HU7RV0 (ChemIDplus, GSRS) |
Target
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Financial
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Safety
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Adverse Events
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239 adverse events reported
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