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Drug ReportsEdetate
Edetic acid
Edetate (edetic acid) is a small molecule pharmaceutical. Edetic acid was first approved as Calcium disodium versenate on 1982-01-01. It is used to treat drug overdose, hypercalcemia, and ventricular tachycardia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Edetate, Iosat, Potassium iodide, Thyrosafe (discontinued: Potassium iodide, Thyro-block, Versenate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Edetate calcium disodium
Tradename
Company
Number
Date
Products
CALCIUM DISODIUM VERSENATEBausch Health CompaniesN-008922 DISCN1982-01-01
2 products
Hide discontinued
Dextrose
+
Magnesium acetate tetrahydrate
+
Potassium acetate
+
Sodium chloride
Tradename
Company
Number
Date
Products
PLASMA-LYTE 56 AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-017385 DISCN1982-01-01
1 products
Hide discontinued
Magnesium acetate tetrahydrate
+
Potassium acetate
+
Sodium chloride
Tradename
Company
Number
Date
Products
PLASMA-LYTE 56 IN PLASTIC CONTAINERBaxterN-019047 DISCN1984-06-15
1 products
Hide discontinued
Potassium iodide
Tradename
Company
Number
Date
Products
IOSATAnbexN-018664 OTC1982-10-14
2 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
edetate calcium disodiumANDA2024-05-15
endrate2006-05-11
miin footOTC monograph not final2019-08-22
miracle footcream lavenderunapproved drug other2022-03-28
miracle footcream lemonunapproved drug other2022-03-28
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
EDETATE CALCIUM DISODIUM, EDETATE CALCIUM DISODIUM, CASPER PHARMA LLC
2024-01-08CGT
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
673 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PeriodontitisD010518EFO_0000649K05.323252535
InfectionsD007239EFO_000054443211826
CarcinomaD002277C80.061021625
Covid-19D000086382U07.11212023
Periapical periodontitisD010485EFO_1001391K04.513111823
Postoperative painD010149G89.181131722
Dental pulp necrosisD003790K04.13111216
Communicable diseasesD0031413311915
Liver neoplasmsD008113EFO_1001513C22.0331613
Dental pulp diseasesD003788EFO_0009540K04411813
Show 34 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61522111040
NeoplasmsD009369C803731827
Castration-resistant prostatic neoplasmsD06412919411
AdenocarcinomaD00023062411
RecurrenceD012008245210
Iron deficienciesD000090463E61.11910
AnemiaD000740EFO_0004272D64.92179
Diabetes mellitusD003920EFO_0000400E08-E132259
AsthmaD001249EFO_0000270J452349
Periodontal diseasesD010510K05.6189
Show 38 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SyndromeD013577231923
Breast neoplasmsD001943EFO_0003869C50211821
Healthy volunteers/patients521015
SepsisD018805EFO_0001420A41.911213
HypersensitivityD006967EFO_0003785T78.401279
Renal insufficiencyD051437N191189
Myelodysplastic syndromesD009190D462157
Myeloid leukemiaD007951C922247
Liver diseasesD008107EFO_0001421K70-K77167
Myeloid leukemia acuteD015470C92.02236
Show 60 more
Indications Phases 1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PulpitisD011671EFO_1001139K04.01111
Circulating neoplastic cellsD00936088
Septic shockD012772A48.388
Hiv infectionsD015658EFO_0000764B2088
Gingival recessionD005889K06.077
Periapical diseasesD010483EFO_001068866
ShockD012769R57.144
Heart diseasesD006331EFO_0003777I51.944
Sickle cell anemiaD000755EFO_0000697D5744
Acute coronary syndromeD054058EFO_000567244
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEdetic acid
INNedetic acid
Description
Ethylenediaminetetraacetic acid is a tetracarboxylic acid, an ethylenediamine derivative and a polyamino carboxylic acid. It has a role as an antidote, a geroprotector, a chelator, a copper chelator and an anticoagulant. It is a conjugate acid of an EDTA(2-).
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O
Identifiers
PDB
CAS-ID150-43-6
RxCUI
ChEMBL IDCHEMBL858
ChEBI ID42191
PubChem CID6049
DrugBankDB00974
UNII ID9G34HU7RV0 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 741,321 documents
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Safety
Black-box Warning
Black-box warning for: Edetate calcium disodium, Endrate
Adverse Events
Top Adverse Reactions
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229 adverse events reported
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