Edetic acid
Edetate (edetic acid) is a small molecule pharmaceutical. Edetic acid was first approved as Calcium disodium versenate on 1982-01-01. It is used to treat drug overdose, hypercalcemia, and ventricular tachycardia in the USA.
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Commercial
Trade Name
FDA
EMA
Edetate, Iosat, Potassium iodide, Thyrosafe (discontinued: Potassium iodide, Thyro-block, Versenate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Edetate calcium disodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CALCIUM DISODIUM VERSENATE | Bausch Health Companies | N-008922 DISCN | 1982-01-01 | 2 products |
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Dextrose
+
Magnesium acetate tetrahydrate
+
Potassium acetate
+
Sodium chloride
Magnesium acetate tetrahydrate
+
Potassium acetate
+
Sodium chloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| edetate calcium disodium | ANDA | 2024-05-15 |
| endrate | 2006-05-11 | |
| miin foot | OTC monograph not final | 2019-08-22 |
| miracle footcream lavender | unapproved drug other | 2022-03-28 |
| miracle footcream lemon | unapproved drug other | 2022-03-28 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
EDETATE CALCIUM DISODIUM, EDETATE CALCIUM DISODIUM, CASPER PHARMA LLC | |||
| 2024-01-08 | CGT | ||
Patent Expiration
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ATC Codes
No data
HCPCS
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Clinical
Clinical Trials
664 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 2 | 3 | 2 | 5 | 24 | 34 |
| Infections | D007239 | EFO_0000544 | — | 4 | 3 | 2 | 1 | 18 | 26 |
| Carcinoma | D002277 | — | C80.0 | 6 | 10 | 2 | 1 | 5 | 24 |
| Covid-19 | D000086382 | — | — | — | 1 | 2 | 1 | 20 | 23 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | 1 | 3 | 1 | 1 | 17 | 22 |
| Postoperative pain | D010149 | — | G89.18 | 1 | 1 | — | 3 | 16 | 21 |
| Dental pulp necrosis | D003790 | — | K04.1 | — | 3 | 1 | 1 | 12 | 16 |
| Communicable diseases | D003141 | — | — | 3 | 3 | 1 | 1 | 9 | 15 |
| Dental pulp diseases | D003788 | EFO_0009540 | K04 | — | 4 | 1 | 1 | 8 | 13 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | 1 | 10 | 13 |
Show 34 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 5 | 22 | 11 | — | 10 | 40 |
| Neoplasms | D009369 | — | C80 | 3 | 7 | 3 | — | 18 | 27 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | 9 | 4 | — | — | 11 |
| Adenocarcinoma | D000230 | — | — | — | 6 | 2 | — | 4 | 11 |
| Recurrence | D012008 | — | — | 2 | 4 | 5 | — | 2 | 10 |
| Iron deficiencies | D000090463 | — | — | — | — | 1 | — | 9 | 10 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 2 | 1 | — | 7 | 9 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 2 | 2 | — | 5 | 9 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 2 | 3 | — | 4 | 9 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | 1 | — | 8 | 9 |
Show 40 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 2 | 3 | — | — | 19 | 23 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | 18 | 21 |
| Healthy volunteers/patients | — | — | — | 4 | 1 | — | — | 10 | 14 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | 12 | 13 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | 2 | — | — | 7 | 9 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | 1 | — | — | 8 | 9 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 1 | — | — | 5 | 7 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | — | — | 6 | 7 |
| Myeloid leukemia | D007951 | — | C92 | 2 | 1 | — | — | 4 | 6 |
| Lymphoma | D008223 | — | C85.9 | 4 | 4 | — | — | 2 | 6 |
Show 59 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | 7 | 8 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | 7 | 8 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | 6 | 7 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | 6 | 7 |
| Virus diseases | D014777 | — | B34 | 2 | — | — | — | 4 | 6 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | 4 | 5 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | 2 | — | — | — | 3 | 5 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | 3 | 4 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | 3 | 4 |
| Sarcoma | D012509 | — | — | 2 | — | — | — | 1 | 3 |
Show 28 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | — | — | — | 9 | 9 |
| Circulating neoplastic cells | D009360 | — | — | — | — | — | — | 8 | 8 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 8 | 8 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 8 | 8 |
| Gingival recession | D005889 | — | K06.0 | — | — | — | — | 7 | 7 |
| Periapical diseases | D010483 | EFO_0010688 | — | — | — | — | — | 6 | 6 |
| Shock | D012769 | — | R57.1 | — | — | — | — | 4 | 4 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 4 | 4 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 4 | 4 |
Show 356 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Edetic acid |
| INN | edetic acid |
| Description | Ethylenediaminetetraacetic acid is a tetracarboxylic acid, an ethylenediamine derivative and a polyamino carboxylic acid. It has a role as an antidote, a geroprotector, a chelator, a copper chelator and an anticoagulant. It is a conjugate acid of an EDTA(2-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 150-43-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL858 |
| ChEBI ID | 42191 |
| PubChem CID | 6049 |
| DrugBank | DB00974 |
| UNII ID | 9G34HU7RV0 (ChemIDplus, GSRS) |
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Trends
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Safety
Black-box Warning
Black-box warning for: Edetate calcium disodium, Endrate
Adverse Events
Top Adverse Reactions
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229 adverse events reported
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