Edetic acid
Edetate (edetic acid) is a small molecule pharmaceutical. Edetic acid was first approved as Calcium disodium versenate on 1982-01-01. It is used to treat drug overdose, hypercalcemia, and ventricular tachycardia in the USA.
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Edetate calcium disodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CALCIUM DISODIUM VERSENATE | Bausch Health Companies | N-008922 DISCN | 1982-01-01 | 2 products |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| calcium edetate de sodium | unapproved drug for use in drug shortage | 2023-04-27 |
| edetate calcium disodium | ANDA | 2023-04-13 |
| endrate | 2006-05-11 | |
| miin foot | OTC monograph not final | 2019-08-22 |
| miracle footcream lemon | unapproved drug other | 2022-03-28 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| drug overdose | — | D062787 | — |
| hypercalcemia | HP_0003072 | D006934 | E83.52 |
| ventricular tachycardia | — | D017180 | I47.2 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
EDETATE CALCIUM DISODIUM, EDETATE CALCIUM DISODIUM, CASPER PHARMA LLC | |||
| 2024-01-08 | CGT | ||
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Clinical
Clinical Trials
209 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 2 | — | 1 | 3 | 8 |
| Tetanus | D013742 | EFO_0005593 | A35 | — | 1 | 4 | 2 | — | 7 |
| Diphtheria | D004165 | EFO_0005549 | A36 | — | 1 | 4 | 2 | — | 7 |
| Poliomyelitis | D011051 | EFO_0007450 | A80 | — | 1 | 3 | 1 | — | 5 |
| Hepatitis b | D006509 | — | — | — | 1 | 2 | 1 | — | 4 |
| Haemophilus influenzae type b | D019741 | — | — | — | 1 | 2 | 1 | — | 4 |
| Microbial drug resistance | D004352 | — | — | — | — | — | 1 | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | — | 1 |
| Dental plaque | D003773 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 4 | 16 | 11 | — | 3 | 27 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | 6 | 4 | — | — | 8 |
| Adenocarcinoma | D000230 | — | — | — | 4 | 2 | — | 1 | 6 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 2 | 1 | — | 1 | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 2 | 1 | — | — | 3 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 1 | 1 | — | 2 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 2 | — | 1 | 3 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 2 | — | 1 | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | 1 | — | 1 | 3 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | — | 1 | — | — | 2 |
Show 14 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | 3 | 2 | — | — | 2 | 7 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | 5 | 6 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 2 | — | — | 1 | 4 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 1 | — | — | 2 | 3 |
| Hodgkin disease | D006689 | — | C81 | 2 | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | — | 2 |
| Infections | D007239 | EFO_0000544 | — | 1 | 2 | — | — | — | 2 |
| Anus neoplasms | D001005 | EFO_0003835 | C21 | — | 1 | — | — | — | 1 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | HP_0001919 | N17 | 2 | — | — | — | 2 | 4 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 2 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | — | — | — | 1 | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | 2 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | 1 | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | 1 | 2 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | — | — | — | 1 | 2 |
| Synovial sarcoma | D013584 | — | — | 2 | — | — | — | — | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | — | — | — | 1 | 2 |
Show 16 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 3 | 3 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 2 | 2 |
| Keratoconus | D007640 | EFO_0004223 | H18.6 | — | — | — | — | 2 | 2 |
| Periodontal pocket | D010514 | EFO_1001393 | — | — | — | — | — | 2 | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | — | — | 2 | 2 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | — | 2 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Epidermolysis bullosa dystrophica | D016108 | — | Q81.2 | — | — | — | — | 1 | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
Show 42 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Edetic acid |
| INN | edetic acid |
| Description | Ethylenediaminetetraacetic acid is a tetracarboxylic acid, an ethylenediamine derivative and a polyamino carboxylic acid. It has a role as an antidote, a geroprotector, a chelator, a copper chelator and an anticoagulant. It is a conjugate acid of an EDTA(2-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 150-43-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL858 |
| ChEBI ID | 42191 |
| PubChem CID | 6049 |
| DrugBank | DB00974 |
| UNII ID | 9G34HU7RV0 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Edetate calcium disodium, Endrate
Adverse Events
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132 adverse events reported
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