Edetic acid
Edetate (edetic acid) is a small molecule pharmaceutical. Edetic acid was first approved as Calcium disodium versenate on 1982-01-01. It is used to treat drug overdose, hypercalcemia, and ventricular tachycardia in the USA.
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Commercial
Trade Name
FDA
EMA
Edetate, Iosat, Potassium iodide, Thyrosafe (discontinued: Potassium iodide, Thyro-block, Versenate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Edetate calcium disodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CALCIUM DISODIUM VERSENATE | Bausch Health Companies | N-008922 DISCN | 1982-01-01 | 2 products |
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Dextrose
+
Magnesium acetate tetrahydrate
+
Potassium acetate
+
Sodium chloride
Magnesium acetate tetrahydrate
+
Potassium acetate
+
Sodium chloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| edetate calcium disodium | ANDA | 2024-05-15 |
| endrate | 2006-05-11 | |
| miin foot | OTC monograph not final | 2019-08-22 |
| miracle footcream lavender | unapproved drug other | 2022-03-28 |
| miracle footcream lemon | unapproved drug other | 2022-03-28 |
Indications
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EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
EDETATE CALCIUM DISODIUM, EDETATE CALCIUM DISODIUM, CASPER PHARMA LLC | |||
| 2024-01-08 | CGT | ||
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Clinical
Clinical Trials
650 clinical trials
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Indications Phases 4
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Hemophilia b | D002836 | — | D67 | — | — | — | — | 1 | 1 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | — | — | — | 1 | 1 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | — | — | — | — | 1 | 1 |
| Familial amyloid neuropathies | D028227 | — | E85.1 | — | — | — | — | 1 | 1 |
| Amyloid neuropathies | D017772 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Edetic acid |
| INN | edetic acid |
| Description | Ethylenediaminetetraacetic acid is a tetracarboxylic acid, an ethylenediamine derivative and a polyamino carboxylic acid. It has a role as an antidote, a geroprotector, a chelator, a copper chelator and an anticoagulant. It is a conjugate acid of an EDTA(2-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 150-43-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL858 |
| ChEBI ID | 42191 |
| PubChem CID | 6049 |
| DrugBank | DB00974 |
| UNII ID | 9G34HU7RV0 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Edetate calcium disodium, Endrate
Adverse Events
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212 adverse events reported
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