Econazole
Econazole, Ecoza (econazole) is a small molecule pharmaceutical. Econazole was first approved as Spectazole on 1982-12-23. It is used to treat cutaneous candidiasis, mycoses, tinea pedis, and tinea versicolor in the USA. It is known to target transient receptor potential cation channel subfamily V member 5 and transient receptor potential cation channel subfamily M member 2.
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FDA approval date
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Econazole, Ecoza (discontinued: Econazole, Spectazole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Econazole nitrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ECOZA | Resilia Pharmaceuticals | N-205175 RX | 2013-10-24 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 071023 econazole nitrate 1% / niacinamide 4% | unapproved drug other | 2020-07-02 |
| econazole nitrate | New Drug Application | 2025-09-13 |
| econazole nitrate 1% / niacinamide 4% | unapproved drug other | 2019-05-20 |
| ecoza | New Drug Application | 2023-12-04 |
| pm external | unapproved drug other | 2019-03-19 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| mycoses | — | D009181 | B35-B49 |
| tinea pedis | EFO_0007512 | D014008 | B35.3 |
| tinea versicolor | EFO_0007439 | D014010 | B36.0 |
| cutaneous candidiasis | — | D002179 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Econazole Nitrate, Ecoza, Resilia Pharms | |||
| 10071054 | 2031-08-08 | DP | |
ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AC: Imidazole and triazole derivatives, topical antifungals
— D01AC03: Econazole
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AF: Imidazole derivatives, gyncological antiinfectives
— G01AF05: Econazole
— G01AF55: Econazole, combinations
HCPCS
No data
Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Otomycosis | D059249 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tinea | D014005 | EFO_0007510 | B35.4 | — | 2 | 3 | — | — | 5 |
| Tinea pedis | D014008 | EFO_0007512 | B35.3 | — | 2 | 3 | — | — | 5 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Onychomycosis | D014009 | — | B35.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Econazole |
| INN | econazole |
| Description | 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group. It is an ether, a member of imidazoles, a dichlorobenzene and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | systemic antifungals (miconazole type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1069-66-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL808 |
| ChEBI ID | 82873 |
| PubChem CID | 3198 |
| DrugBank | DB01127 |
| UNII ID | 6Z1Y2V4A7M (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
TRPV5
TRPV5
TRPM2
TRPM2
Organism
Homo sapiens
Gene name
TRPV5
Gene synonyms
ECAC1
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily V member 5
Protein synonyms
Calcium transport protein 2, calcium transporter 2, CaT2, ECaC, ECaC1, Epithelial calcium channel 1, Osm-9-like TRP channel 3, OTRPC3
Uniprot ID
Mouse ortholog
Trpv5 (194352)
transient receptor potential cation channel subfamily V member 5 (Q2TB50)
Variants
No data
Financial
Revenue by drug
$
€
£
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Estimated US medical usage
Econazole
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,186 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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638 adverse events reported
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