Echothiophate
Echothiophate Iodide (echothiophate) is a small molecule pharmaceutical. Echothiophate was first approved as Phospholine iodide on 1982-01-01. It is known to target acetylcholinesterase.
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Commercial
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Trade Name
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Phospholine iodide (discontinued: Phospholine iodide)
Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Echothiophate iodide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PHOSPHOLINE IODIDE | Fera Pharmaceuticals | N-011963 RX | 1982-01-01 | 1 products, RLD, RS |
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Brand Name | Status | Last Update |
|---|---|---|
| phospholine iodide | New Drug Application | 2025-07-07 |
Indications
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Clinical
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | 1 | — | 1 |
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Epidemiology
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Drug
General
| Drug common name | Echothiophate |
| INN | _ |
| Description | Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor and a miotic. It is an organic thiophosphate, a member of phosphocholines and a quaternary ammonium ion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOP(=O)(OCC)SCC[N+](C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 6736-03-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201341 |
| ChEBI ID | 4753 |
| PubChem CID | 10548 |
| DrugBank | DB01057 |
| UNII ID | BA9QH3P00T (ChemIDplus, GSRS) |
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160 adverse events reported
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