ELUBRIXIN
Elubrixin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against C-X-C chemokine receptor type 2.
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Events Timeline
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2Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | 1 | 1 | — | — | — | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | 1 | — | — | — | 2 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | — | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | 1 | — | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 3 | — | — | — | — | 3 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ELUBRIXIN |
| INN | elubrixin |
| Description | Elubrixin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against C-X-C chemokine receptor type 2. |
| Classification | Small molecule |
| Drug class | chemokine (C-X-C motif) receptor 2 (CXCR2) modulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(Nc1ccc(Cl)c(S(=O)(=O)N2CCNCC2)c1O)Nc1cccc(F)c1Cl |
Identifiers
| PDB | — |
| CAS-ID | 688763-64-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2178579 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | MW2AIJ8USP (ChemIDplus, GSRS) |
Target
Agency Approved
CXCR2
CXCR2
Organism
Homo sapiens
Gene name
CXCR2
Gene synonyms
IL8RB
NCBI Gene ID
Protein name
C-X-C chemokine receptor type 2
Protein synonyms
CD182, CDw128b, chemokine (CXC) receptor 2, CXC-R2, CXCR-2, CXCR2 gene for IL8 receptor type B, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8 receptor type 2, IL-8R B, interleukin 8 receptor type 2, interleukin 8 receptor, beta, interleukin-8 receptor type B
Uniprot ID
Mouse ortholog
Cxcr2 (12765)
C-X-C chemokine receptor type 2 (Q53X27)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 29 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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