ELIMUSERTIB
Elimusertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serine/threonine-protein kinase ATR.
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Commercial
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 1 | — | — | — | 6 |
| Recurrence | D012008 | — | — | 2 | 1 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | 1 | — | — | — | 2 |
| Sarcoma | D012509 | — | — | 1 | 1 | — | — | — | 1 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 1 | 1 | — | — | — | 1 |
| Rhabdomyosarcoma | D012208 | — | — | 1 | 1 | — | — | — | 1 |
| Alveolar rhabdomyosarcoma | D018232 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | — | — | — | — | 3 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | — | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | — | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | — | — | — | — | 2 |
| Small cell lung carcinoma | D055752 | — | — | 2 | — | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Digestive system neoplasms | D004067 | — | — | 1 | — | — | — | — | 1 |
| Small cell carcinoma | D018288 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ELIMUSERTIB |
| INN | elimusertib |
| Description | Elimusertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target serine/threonine-protein kinase ATR. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1COCCN1c1cc(-c2ccnn2C)c2ccnc(-c3ccn[nH]3)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 1876467-74-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4647810 |
| ChEBI ID | — |
| PubChem CID | 118869362 |
| DrugBank | DB19041 |
| UNII ID | 7N13IK9LNH (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ATR
ATR
Organism
Homo sapiens
Gene name
ATR
Gene synonyms
FRP1
NCBI Gene ID
Protein name
serine/threonine-protein kinase ATR
Protein synonyms
Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, FRAP-related protein-1, MEC1, mitosis entry checkpoint 1, homolog
Uniprot ID
Mouse ortholog
Atr (245000)
serine/threonine-protein kinase ATR (Q9JKK8)
Variants
No data
Financial
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Trends
PubMed Central
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Additional graphs summarizing 312 documents
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Safety
Black-box Warning
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Adverse Events
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