EFINOPEGDUTIDE
Efinopegdutide is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 4 | — | — | — | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 1 | — | — | — | 3 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 1 | — | — | — | 3 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 3 | — | — | — | 3 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 3 | — | — | — | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Overweight | D050177 | — | E66.3 | 1 | — | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Alcoholic fatty liver | D005235 | — | K70.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | EFINOPEGDUTIDE |
| INN | efinopegdutide |
| Description | Efinopegdutide (MK-6024) is a dual agonist of the glucagon and GLP-1 receptors. It is being developed by Merck for non-alcoholic fatty liver disease. It was also developed for type 2 diabetes and obesity but these indications were discontinued.
|
| Classification | Protein |
| Drug class | Fc fusion protein; peptides: oxyntomodulin analogs; PEGylated compounds, covalent attachment of macrogol (polyethylene glycol) polymer |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297576 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | DR6P1M58PO (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Additional graphs summarizing 131 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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