EDICOTINIB
Edicotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against macrophage colony-stimulating factor 1 receptor. In addition, it is known to target receptor-type tyrosine-protein kinase FLT3 and mast/stem cell growth factor receptor Kit.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
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YTD
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2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Crohn disease | D003424 | EFO_0000384 | K50 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | EDICOTINIB |
| INN | edicotinib |
| Description | Edicotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against macrophage colony-stimulating factor 1 receptor. In addition, it is known to target receptor-type tyrosine-protein kinase FLT3 and mast/stem cell growth factor receptor Kit. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CC=C(c2nc(C3CC(C)(C)OC(C)(C)C3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1142363-52-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3674570 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3NU609VYNF (ChemIDplus, GSRS) |
Target
Agency Approved
CSF1R
CSF1R
Organism
Homo sapiens
Gene name
CSF1R
Gene synonyms
FMS
NCBI Gene ID
Protein name
macrophage colony-stimulating factor 1 receptor
Protein synonyms
CD115, CD115 antigen, CSF-1 receptor, CSF-1-R, CSF-1R, FMS proto-oncogene, M-CSF-R, macrophage colony stimulating factor I receptor, McDonough feline sarcoma viral (v-fms) oncogene homolog, Proto-oncogene c-Fms
Uniprot ID
Mouse ortholog
Csf1r (12978)
macrophage colony-stimulating factor 1 receptor (Q9DBH9)
Alternate
FLT3
FLT3
KIT
KIT
Organism
Homo sapiens
Gene name
FLT3
Gene synonyms
CD135, FLK2, STK1
NCBI Gene ID
Protein name
receptor-type tyrosine-protein kinase FLT3
Protein synonyms
CD135, CD135 antigen, fetal liver kinase 2, Fetal liver kinase-2, FL cytokine receptor, FLK-2, FLT-3, fms related tyrosine kinase 3, Fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, Stem cell tyrosine kinase 1, STK-1
Uniprot ID
Mouse ortholog
Flt3 (14255)
receptor-type tyrosine-protein kinase FLT3 (Q00342)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 52 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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