Dyphylline
Dilor, Lufyllin, Neothylline (dyphylline) is a small molecule pharmaceutical. Dyphylline was first approved as Neothylline on 1982-01-01. It is used to treat asthma and bronchitis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| immune system diseases | D007154 |
Trade Name
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Drug Products
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Indications
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| asthma | EFO_0000270 | D001249 | J45 |
| bronchitis | — | D001991 | J40 |
Agency Specific
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ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA01: Diprophylline
— R03DA51: Diprophylline, combinations
— R03DB: Xanthines and adrenergics
— R03DB01: Diprophylline and adrenergics
HCPCS
Code | Description |
|---|---|
| J1180 | Injection, dyphylline, up to 500 mg |
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dyphylline |
| INN | diprophylline |
| Description | Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs. It has a role as a bronchodilator agent, a vasodilator agent, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and a muscle relaxant. It is an oxopurine and a member of propane-1,2-diols. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)c2c(ncn2CC(O)CO)n(C)c1=O |
Identifiers
| PDB | — |
| CAS-ID | 479-18-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1752 |
| ChEBI ID | 4728 |
| PubChem CID | 3182 |
| DrugBank | DB00651 |
| UNII ID | 263T0E9RR9 (ChemIDplus, GSRS) |
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Estimated US medical usage
Dyphylline
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Dyphylline
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Guaifenesin
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Additional graphs summarizing 409 documents
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Safety
Black-box Warning
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Adverse Events
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60 adverse events reported
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