Duvoglustat
Duvoglustat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target lysosomal alpha-glucosidase.
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Commercial
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glycogen storage disease type ii | D006009 | Orphanet_365 | E74.02 | — | 2 | — | — | 1 | 3 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fabry disease | D000795 | Orphanet_324 | E75.21 | 3 | — | — | — | 1 | 4 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Duvoglustat |
| INN | duvoglustat |
| Description | Duvoglustat is an optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an anti-HIV agent, an anti-obesity agent, a bacterial metabolite, a hypoglycemic agent, a hepatoprotective agent and a plant metabolite. It is a 2-(hydroxymethyl)piperidine-3,4,5-triol and a piperidine alkaloid. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: glucosyltransferase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 19130-96-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL307429 |
| ChEBI ID | 44369 |
| PubChem CID | 29435 |
| DrugBank | DB03206 |
| UNII ID | FZ56898FLE (ChemIDplus, GSRS) |
Target
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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