Tradename | Proper name | Company | Number | Date | Products |
---|---|---|---|---|---|
Dupixent | dupilumab | Regeneron Pharmaceuticals | N-761055 RX | 2017-03-28 | 5 products |
Brand Name | Status | Last Update |
---|---|---|
dupixent | Biologic Licensing Application | 2024-01-17 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
atopic dermatitis | EFO_0000274 | D003876 | L20 |
Expiration | Code | ||
---|---|---|---|
dupilumab, Dupixent, Regeneron Pharmaceuticals, Inc. | |||
2029-05-20 | Orphan excl. |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Atopic dermatitis | D003876 | EFO_0000274 | L20 | 5 | 13 | 17 | 23 | 24 | 81 |
Asthma | D001249 | EFO_0000270 | J45 | 1 | 6 | 9 | 9 | 13 | 38 |
Nasal polyps | D009298 | HP_0100582 | J33 | — | 2 | 2 | 5 | 4 | 13 |
Eczema | D004485 | HP_0000964 | L30.9 | — | 1 | 1 | 4 | — | 6 |
Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | 2 | 1 | 1 | 5 |
Eosinophilia | D004802 | HP_0001880 | D72.1 | — | 1 | — | 1 | — | 2 |
Allergic contact dermatitis | D017449 | — | L23 | — | 1 | 1 | 1 | — | 2 |
Keloid | D007627 | EFO_0004212 | L91.0 | — | 1 | — | 1 | — | 2 |
Lamellar ichthyosis | D017490 | — | Q80 | — | — | — | 1 | — | 1 |
Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | 1 | — | 3 | 4 |
Chronic urticaria | D000080223 | — | L50.8 | — | 1 | 2 | — | — | 3 |
Dermatitis | D003872 | HP_0011123 | L30.9 | 1 | — | 2 | — | — | 3 |
Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 2 | — | — | 2 |
Pruritus | D011537 | HP_0000989 | L29 | — | 1 | 1 | — | — | 2 |
Neurodermatitis | D009450 | — | L28.0 | — | — | 2 | — | — | 2 |
Immune system diseases | D007154 | — | D89.9 | — | — | 2 | — | — | 2 |
Skin diseases | D012871 | — | L00-L99 | 1 | — | 1 | — | — | 2 |
Eczematous skin diseases | D017443 | — | — | — | — | 2 | — | — | 2 |
Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 1 | 1 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Peanut hypersensitivity | D021183 | EFO_0007425 | — | — | 3 | — | — | — | 3 |
Alopecia areata | D000506 | EFO_0004192 | L63 | — | 3 | — | — | — | 3 |
Food hypersensitivity | D005512 | EFO_1001890 | — | — | 1 | — | — | 1 | 2 |
Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | 1 | 2 |
Respiration disorders | D012120 | — | J00-J99 | — | 1 | — | — | — | 1 |
Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | — | — | — | 1 |
Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | — | 1 | — | — | — | 1 |
Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | — | 1 | — | — | — | 1 |
Allergic bronchopulmonary aspergillosis | D001229 | EFO_0007140 | B44.81 | — | 1 | — | — | — | 1 |
Keratoconjunctivitis | D007637 | — | H16.2 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Psoriasis | D011565 | EFO_0000676 | L40 | — | — | — | — | 1 | 1 |
Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | — | 1 | 1 |
Conjunctivitis | D003231 | HP_0000509 | H10 | — | — | — | — | 1 | 1 |
Conjunctival diseases | D003229 | — | H10-H11 | — | — | — | — | 1 | 1 |
Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
Anosmia | D000086582 | — | — | — | — | — | — | 1 | 1 |
Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 1 | 1 |
Drug common name | Dupilumab |
INN | dupilumab |
Description | Dupilumab (human mab) |
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | >6WG8:A|Dupilumab Fab heavy chain
EVQLVESGGGLEQPGGSLRLSCAGSGFTFRDYAMTWVRQAPGKGLEWVSSISGSGGNTYYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAVYYCAKDRLSITIRPRYYGLDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPE
PVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGHHHHHH
>6WG8:B|Dupilumab Fab light chain
DIVMTQSPLSLPVTPGEPASISCRSSQSLLYSIGYNYLDWYLQKSGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKI
SRVEAEDVGFYYCMQALQTPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC |
PDB | 6WG8, 6WGB, 6WGJ, 6WGK, 6WGL |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL2108675 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB12159 |
UNII ID | 420K487FSG (ChemIDplus, GSRS) |