Trulicity(dulaglutide)
Trulicity (dulaglutide) is a protein pharmaceutical. Dulaglutide was first approved as Trulicity on 2014-09-18. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
Trulicity (discontinued: Trulicity)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| trulicity | Biologic Licensing Application | 2025-11-18 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
127 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 20 | 16 | 32 | 14 | 17 | 97 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 8 | 13 | 18 | 9 | 9 | 57 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 6 | 3 | 9 |
| Healthy volunteers/patients | — | — | — | 5 | — | — | 1 | 1 | 7 |
| Overweight | D050177 | — | E66.3 | — | 1 | — | 3 | 1 | 5 |
| Hyperglycemia | D006943 | — | R73.9 | — | 1 | — | 3 | — | 4 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 2 | — | 2 | — | 4 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | — | 2 | 2 | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | — | 1 | 2 | 4 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | 5 | 6 |
| Glucose metabolism disorders | D044882 | — | — | — | — | 2 | — | — | 2 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | 2 | — | — | 2 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | 2 | — | — | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | 1 | — | — | 2 |
| Ischemic stroke | D000083242 | — | — | — | 1 | 1 | — | — | 1 |
| Intracranial arteriosclerosis | D002537 | EFO_1000860 | I67.2 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | — | 1 | — | — | — | 1 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | — | — | — | 1 |
| Exocrine pancreatic insufficiency | D010188 | — | K86.81 | — | 1 | — | — | — | 1 |
| Sexual arousal | D000083942 | — | — | — | 1 | — | — | — | 1 |
| Body weight changes | D001836 | — | — | — | 1 | — | — | — | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | 1 | — | — | — | 1 |
| Craving | D066249 | — | — | — | 1 | — | — | — | 1 |
| Water-electrolyte imbalance | D014883 | — | — | — | 1 | — | — | — | 1 |
| Thirst | D013894 | — | — | — | 1 | — | — | — | 1 |
| Psychogenic polydipsia | D059607 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart disease risk factors | D000082742 | — | — | — | — | — | — | 2 | 2 |
| Carcinoma | D002277 | — | C80.0 | — | — | — | — | 1 | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | — | — | — | 1 | 1 |
| Neuroendocrine carcinoma | D018278 | — | — | — | — | — | — | 1 | 1 |
| Papillary thyroid cancer | D000077273 | — | — | — | — | — | — | 1 | 1 |
| Thyroid diseases | D013959 | — | E00-E07 | — | — | — | — | 1 | 1 |
| Pediatric obesity | D063766 | — | — | — | — | — | — | 1 | 1 |
| Retinal diseases | D012164 | — | H35.9 | — | — | — | — | 1 | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dulaglutide |
| INN | dulaglutide |
| Description | Dulaglutide, sold under the brand name Trulicity among others, is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. It is also approved in the United States for the reduction of major adverse cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors. It is a once-weekly injection.
|
| Classification | Protein |
| Drug class | peptides: glucagon-like peptide (GLP) analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108027 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB09045 |
| UNII ID | WTT295HSY5 (ChemIDplus, GSRS) |
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Trulicity – Eli Lilly
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Estimated US medical usage
Dulaglutide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,749 documents
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Safety
Black-box Warning
Black-box warning for: Trulicity
Adverse Events
Top Adverse Reactions
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72,514 adverse events reported
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