Therapeutic Area | MeSH |
---|---|
nervous system diseases | D009422 |
cardiovascular diseases | D002318 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
orthostatic hypotension | — | D007024 | I95.1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypotension | D007022 | EFO_0005251 | I95 | 3 | 6 | 9 | 5 | 1 | 22 |
Orthostatic hypotension | D007024 | — | I95.1 | 2 | 5 | 9 | 5 | 1 | 20 |
Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 6 | 2 | 4 | 1 | 14 |
Fatigue | D005221 | HP_0012378 | R53.83 | — | 2 | — | 1 | — | 3 |
Parkinsonian disorders | D020734 | HP_0001300 | G20.C | — | 1 | — | 1 | — | 2 |
Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | — | — | 1 | — | 2 |
Wounds and injuries | D014947 | — | T14.8 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 2 | 3 | 5 | — | 1 | 8 |
Shy-drager syndrome | D012791 | EFO_1001050 | — | 2 | 3 | 3 | — | 1 | 7 |
Multiple system atrophy | D019578 | — | — | 2 | 3 | 3 | — | 1 | 7 |
Pure autonomic failure | D054970 | — | — | 1 | — | 4 | — | — | 5 |
Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | 1 | — | 4 | — | — | 5 |
Primary dysautonomias | D054969 | — | — | 2 | 3 | 1 | — | 1 | 4 |
Nervous system diseases | D009422 | — | G00-G99 | 2 | 3 | 1 | — | — | 3 |
Orthostatic intolerance | D054971 | — | — | 1 | 2 | 1 | — | 1 | 3 |
Atrophy | D001284 | — | — | — | 1 | 2 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Syndrome | D013577 | — | — | 1 | 3 | — | — | — | 3 |
Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | 2 | — | — | — | 2 |
Tachycardia | D013610 | HP_0001649 | R00.0 | 1 | 2 | — | — | — | 2 |
Neurologic gait disorders | D020233 | HP_0003376 | R26.1 | 1 | 1 | — | — | — | 1 |
Congenital pain insensitivity | D000699 | Orphanet_88642 | G60.8 | — | 1 | — | — | — | 1 |
Hereditary sensory and autonomic neuropathies | D009477 | — | — | — | 1 | — | — | — | 1 |
Hypohidrosis | D007007 | HP_0000966 | L74.4 | — | 1 | — | — | — | 1 |
Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | — | — | — | 1 |
Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | — | — | — | 1 |
Hyperkinesis | D006948 | HP_0000752 | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 3 | — | — | — | — | 3 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Diffuse intrinsic pontine glioma | D000080443 | — | — | 1 | — | — | — | — | 1 |
Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | 1 | — | — | — | — | 1 |
Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
Retinal diseases | D012164 | HP_0000479 | H35.9 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Kyphosis | D007738 | HP_0002808 | M40.20 | — | — | — | — | 1 | 1 |
Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
Drug common name | Droxidopa |
INN | droxidopa |
Description | Droxidopa is a serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension It has a role as a prodrug, a vasoconstrictor agent and an antihypertensive agent. It is a L-tyrosine derivative and a member of catechols. |
Classification | Small molecule |
Drug class | dopamine receptor agonists |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | N[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1 |
PDB | — |
CAS-ID | 23651-95-8 |
RxCUI | — |
ChEMBL ID | CHEMBL2103827 |
ChEBI ID | 31524 |
PubChem CID | 92974 |
DrugBank | DB06262 |
UNII ID | J7A92W69L7 (ChemIDplus, GSRS) |