Droxidopa
Droxidopa, Northera (droxidopa) is a small molecule pharmaceutical. Droxidopa was first approved as Northera on 2014-02-18. It is used to treat orthostatic hypotension in the USA. It is known to target muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Droxidopa, Northera (discontinued: Droxidopa)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| orthostatic hypotension | — | D007024 | I95.1 |
Agency Specific
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Clinical
Clinical Trials
48 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypotension | D007022 | EFO_0005251 | I95 | 3 | 6 | 9 | 5 | 1 | 22 |
| Orthostatic hypotension | D007024 | — | I95.1 | 2 | 5 | 9 | 5 | 1 | 20 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 6 | 2 | 4 | 1 | 14 |
| Fatigue | D005221 | — | R53.83 | — | 2 | — | 1 | — | 3 |
| Parkinsonian disorders | D020734 | — | G20.C | — | 1 | — | 1 | — | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | — | — | 1 | — | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 2 | 3 | 5 | — | 1 | 8 |
| Shy-drager syndrome | D012791 | EFO_1001050 | — | 2 | 3 | 3 | — | 1 | 7 |
| Multiple system atrophy | D019578 | — | — | 2 | 3 | 3 | — | 1 | 7 |
| Pure autonomic failure | D054970 | — | — | 1 | — | 4 | — | — | 5 |
| Peripheral nervous system diseases | D010523 | — | G64 | 1 | — | 4 | — | — | 5 |
| Primary dysautonomias | D054969 | — | — | 2 | 3 | 1 | — | 1 | 4 |
| Nervous system diseases | D009422 | — | G00-G99 | 2 | 3 | 1 | — | — | 3 |
| Orthostatic intolerance | D054971 | — | — | 1 | 2 | 1 | — | 1 | 3 |
| Atrophy | D001284 | — | — | — | 1 | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 1 | 3 | — | — | — | 3 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | 2 | — | — | — | 2 |
| Tachycardia | D013610 | — | R00.0 | 1 | 2 | — | — | — | 2 |
| Neurologic gait disorders | D020233 | — | R26.1 | 1 | 1 | — | — | — | 1 |
| Congenital pain insensitivity | D000699 | Orphanet_88642 | G60.8 | — | 1 | — | — | — | 1 |
| Hereditary sensory and autonomic neuropathies | D009477 | — | — | — | 1 | — | — | — | 1 |
| Hypohidrosis | D007007 | — | L74.4 | — | 1 | — | — | — | 1 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | — | — | — | 1 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | — | — | — | 1 |
| Hyperkinesis | D006948 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 3 | — | — | — | — | 3 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Diffuse intrinsic pontine glioma | D000080443 | — | — | 1 | — | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Retinal diseases | D012164 | — | H35.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kyphosis | D007738 | — | M40.20 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Droxidopa |
| INN | droxidopa |
| Description | Droxidopa is a serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension It has a role as a prodrug, a vasoconstrictor agent and an antihypertensive agent. It is a L-tyrosine derivative and a member of catechols. |
| Classification | Small molecule |
| Drug class | dopamine receptor agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 23651-95-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103827 |
| ChEBI ID | 31524 |
| PubChem CID | 92974 |
| DrugBank | DB06262 |
| UNII ID | J7A92W69L7 (ChemIDplus, GSRS) |
Target
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Safety
Black-box Warning
Black-box warning for: Droxidopa, Northera
Adverse Events
Top Adverse Reactions
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20,120 adverse events reported
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