Droxidopa
Droxidopa, Northera (droxidopa) is a small molecule pharmaceutical. Droxidopa was first approved as Northera on 2014-02-18. It is used to treat orthostatic hypotension in the USA. It is known to target muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Droxidopa, Northera (discontinued: Droxidopa)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| orthostatic hypotension | — | D007024 | I95.1 |
Agency Specific
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | — | 4 | 1 | 7 |
| Orthostatic hypotension | D007024 | — | I95.1 | — | — | — | 3 | — | 3 |
| Multiple system atrophy | D019578 | — | — | — | 1 | — | 1 | — | 2 |
| Pure autonomic failure | D054970 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatigue | D005221 | — | R53.83 | — | 1 | — | — | — | 1 |
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | — | 1 | — | — | — | 1 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | — | 1 | — | — | — | 1 |
| Vasovagal syncope | D019462 | — | R55 | — | 1 | — | — | — | 1 |
| Syncope | D013575 | — | G90.01 | — | 1 | — | — | — | 1 |
| Orthostatic intolerance | D054971 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Droxidopa |
| INN | droxidopa |
| Description | Droxidopa is a serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension It has a role as a prodrug, a vasoconstrictor agent and an antihypertensive agent. It is a L-tyrosine derivative and a member of catechols. |
| Classification | Small molecule |
| Drug class | dopamine receptor agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 23651-95-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103827 |
| ChEBI ID | 31524 |
| PubChem CID | 92974 |
| DrugBank | DB06262 |
| UNII ID | J7A92W69L7 (ChemIDplus, GSRS) |
Target
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Safety
Black-box Warning
Black-box warning for: Droxidopa, Northera
Adverse Events
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20,224 adverse events reported
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