Droperidol
Droperidol, Innovar (droperidol) is a small molecule pharmaceutical. Droperidol was first approved as Inapsine on 1982-01-01. It is used to treat pain and psychotic disorders in the USA.
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Commercial
Trade Name
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Droperidol (discontinued: Droperidol, Inapsine)
Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Droperidol
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Fentanyl citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INNOVAR | Epic Pharma | N-016049 DISCN | 1982-01-01 | 1 products |
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Droperidol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INAPSINE | Rising Pharmaceuticals | N-016796 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| droperidol | ANDA | 2023-03-20 |
| inapsine | 2007-08-09 |
Indications
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EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| psychotic disorders | — | D011618 | F20.81 |
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Clinical
Clinical Trials
40 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | — | R11.1 | — | 1 | 3 | 4 | 3 | 11 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | 1 | 1 | 3 | 4 | 9 |
| Postoperative pain | D010149 | — | G89.18 | — | — | 1 | 2 | 4 | 7 |
| Nausea | D009325 | — | R11.0 | — | 1 | 1 | 2 | 2 | 6 |
| Anesthesia | D000758 | — | — | — | — | 1 | 2 | — | 3 |
| Hallux valgus | D006215 | — | — | — | — | — | 1 | 1 | 2 |
| Chronic pain | D059350 | — | — | — | — | — | 1 | 1 | 2 |
| Emergence delirium | D000071257 | — | — | — | — | — | 1 | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | 1 | — | 1 |
| Gallstones | D042882 | EFO_0004210 | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nerve block | D009407 | — | — | — | — | 1 | — | 1 | 2 |
| Syndrome | D013577 | — | — | — | — | 2 | — | — | 2 |
| Hyperemesis gravidarum | D006939 | EFO_1000971 | O21 | — | — | 2 | — | — | 2 |
| Back pain | D001416 | — | M54 | — | — | 1 | — | — | 1 |
| Local anesthesia | D000772 | — | — | — | — | 1 | — | — | 1 |
| Spinal fusion | D013123 | — | — | — | — | 1 | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | 1 | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
| Psychomotor agitation | D011595 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
| Gynecologic surgical procedures | D013509 | — | — | — | — | — | — | 1 | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | — | — | 1 | 1 |
| Hernia | D006547 | — | K40-K46 | — | — | — | — | 1 | 1 |
| Airway management | D058109 | — | — | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Headache | D006261 | — | R51 | — | — | — | — | 1 | 1 |
| Cluster headache | D003027 | — | G44.00 | — | — | — | — | 1 | 1 |
| Pharmacogenomic testing | D000071185 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Droperidol |
| INN | droperidol |
| Description | Droperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It has a role as an antiemetic, a dopaminergic antagonist, a first generation antipsychotic and an anaesthesia adjuvant. It is a member of benzimidazoles, an organofluorine compound and an aromatic ketone. |
| Classification | Small molecule |
| Drug class | antipsychotics (haloperidol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 548-73-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1108 |
| ChEBI ID | 4717 |
| PubChem CID | 3168 |
| DrugBank | DB00450 |
| UNII ID | O9U0F09D5X (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Droperidol, Inapsine
Adverse Events
Top Adverse Reactions
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1,407 adverse events reported
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