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Drug ReportsDoxorubicin
Doxorubicin hydrochloride, Caelyx pegylated liposomal(doxorubicin)
Doxil, Doxorubicin, Myocet, Pegylated (doxorubicin) is a small molecule pharmaceutical. Doxorubicin was first approved as Doxorubicin hydrochloride on 1982-01-01. It is used to treat breast neoplasms, gastrointestinal neoplasms, hodgkin disease, lung neoplasms, and myeloid leukemia acute amongst others in the USA. It has been approved in Europe to treat breast neoplasms, kaposi sarcoma, multiple myeloma, and ovarian neoplasms.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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EMA approval date
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Study first post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
cardiovascular diseasesD002318
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
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Trade Name
FDA
EMA
Doxil, Doxorubicin (discontinued: Adriamycin, Doxorubicin, Rubex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Doxorubicin hydrochloride
Tradename
Company
Number
Date
Products
DOXIL (LIPOSOMAL)BaxterN-050718 RX1995-11-17
2 products, RLD
DOXORUBICIN HYDROCHLORIDEPfizerN-050629 RX1987-12-23
3 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adriamycinANDA2024-04-11
doxilNew Drug Application2023-08-31
doxorubicin hydrochlorideANDA2024-10-29
doxorubicin hydrochloride liposomeNDA authorized generic2022-05-31
doxorubicin hydrochloride, liposomalunapproved drug for use in drug shortage2023-12-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
myeloid leukemia acute—D015470C92.0
breast neoplasmsEFO_0003869D001943C50
ovarian neoplasmsEFO_0003893D010051C56
thyroid neoplasmsEFO_0003841D013964—
gastrointestinal neoplasms—D005770C26.9
lung neoplasmsHP_0100526D008175C34.90
neuroblastomaEFO_0000621D009447—
precursor cell lymphoblastic leukemia-lymphoma—D054198—
urinary bladder neoplasms—D001749C67
osteosarcoma—D012516—
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01D: Cytotoxic antibiotics and related substances
— L01DB: Anthracyclines and related substances
— L01DB01: Doxorubicin
HCPCS
Code
Description
J9000
Injection, doxorubicin hydrochloride, 10 mg
Q2049
Injection, doxorubicin hydrochloride, liposomal, imported lipodox, 10 mg
Q2050
Injection, doxorubicin hydrochloride, liposomal, not otherwise specified, 10 mg
Clinical
Clinical Trials
2571 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223—C85.91344021831641698
Breast neoplasmsD001943EFO_0003869C50953291291480592
SarcomaD012509——6312350523239
Large b-cell lymphoma diffuseD016403—C83.35013953310225
Ovarian neoplasmsD010051EFO_0003893C567110160216222
CarcinomaD002277—C80.04310244533208
B-cell lymphomaD016393——571204648200
Non-hodgkin lymphomaD008228—C85.94610147611187
LeukemiaD007938—C9542834987172
Ovarian epithelial carcinomaD000077216——547042212161
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80955918—7157
Fallopian tube neoplasmsD005185——303020—170
RecurrenceD012008——243413—667
NeuroblastomaD009447EFO_0000621—102216—351
OsteosarcomaD012516——102011—843
Neoplasm metastasisD009362EFO_0009708—16223—441
Endometrial neoplasmsD016889EFO_0004230—52018——41
Peritoneal neoplasmsD010534——13187—639
AdenocarcinomaD000230——8189—232
Transitional cell carcinomaD002295——8196—129
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Male breast neoplasmsD018567——511——416
Invasive hydatidiform moleD002820—D39.2212——115
Non-small-cell lung carcinomaD002289——48———11
GlioblastomaD005909EFO_0000515—48———11
Plasmablastic lymphomaD000069293—C83.377———11
Large-cell lymphoma immunoblasticD016400——77———11
Aids-related lymphomaD016483EFO_1001365—37———10
Adult t-cell leukemia-lymphomaD015459—C91.546———9
Myelodysplastic syndromesD009190—D4664———8
Reactive arthritisD016918EFO_0007460M02.318———8
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic-myeloproliferative diseasesD054437——4————4
Appendiceal neoplasmsD001063EFO_0003880C18.12———24
Skin neoplasmsD012878EFO_0004198C441———12
Pleural effusionD010996HP_0002202J901———12
Pleural neoplasmsD010997——1———12
Castration-resistant prostatic neoplasmsD064129——1————1
Primary myelofibrosisD055728—D47.41————1
Myelomonocytic leukemia chronicD015477—C93.11————1
AnemiaD000740HP_0001903D64.91————1
Leukemia myeloid chronic atypical bcr-abl negativeD054438—C92.21————1
Show 22 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiovascular diseasesD002318HP_0001626—————33
FatigueD005221HP_0012378R53.83————22
Pseudomyxoma peritoneiD011553EFO_0007456—————22
ThrombosisD013927——————22
Carcinoma in situD002278—D09.9————22
Taste disordersD013651——————11
DysgeusiaD004408—R43.2————11
AgeusiaD000370EFO_1001758—————11
Hepatitis aD006506EFO_0007305B15————11
AtaxiaD001259—R27.0————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDoxorubicin
INNdoxorubicin
Description
Doxorubicin is a deoxy hexoside, an anthracycline, an anthracycline antibiotic, an aminoglycoside, a member of tetracenequinones, a member of p-quinones, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It has a role as an Escherichia coli metabolite. It is a conjugate base of a doxorubicin(1+). It derives from a hydride of a tetracene.
Classification
Small molecule
Drug classantineoplastic antibiotics (daunorubicin type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
Identifiers
PDB—
CAS-ID23214-92-8
RxCUI—
ChEMBL IDCHEMBL53463
ChEBI ID28748
PubChem CID31703
DrugBankDB00997
UNII ID80168379AG (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
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Estimated US medical usage
Doxorubicin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 100,829 documents
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Safety
Black-box Warning
Black-box warning for: Adriamycin, Doxil, Doxorubicin hydrochloride, Doxorubicin hydrochloride liposome
Adverse Events
Top Adverse Reactions
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99,695 adverse events reported
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