Doxazosin
Cardura, Doxazosin (doxazosin) is a small molecule pharmaceutical. Doxazosin was first approved as Cardura on 1990-11-02. It is used to treat hypertension, prostatic hyperplasia, and urinary retention in the USA. The pharmaceutical is active against alpha-1A adrenergic receptor, alpha-1B adrenergic receptor, and alpha-1D adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Cardura, Doxazosin (discontinued: Doxazosin)
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cardura | New Drug Application | 2023-05-15 |
| cardura xl | New Drug Application | 2010-03-24 |
| doxazosin | ANDA | 2024-10-28 |
| doxazosin doxazosin mesylate | NDA authorized generic | 2022-01-20 |
| doxazosin mesylate | ANDA | 2024-01-23 |
| ibuprofen | ANDA | 2022-01-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypertension | EFO_0000537 | D006973 | I10 |
| urinary retention | HP_0000016 | D016055 | R33 |
| prostatic hyperplasia | EFO_0000284 | D011470 | N40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02C: Antiadrenergic agents, peripherally acting
— C02CA: Alpha-adrenoreceptor antagonists, peripherally acting
— C02CA04: Doxazosin
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04C: Drugs used in benign prostatic hypertrophy
— G04CA: Alpha-adrenoreceptor antagonists, benign prostatic hypertrophy
— G04CA55: Doxazosin and finasteride
HCPCS
No data
Clinical
Clinical Trials
73 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 2 | 2 | 10 | 9 | 23 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | 2 | 1 | 3 | 11 | 18 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | 2 | 1 | 3 | 11 | 18 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | 3 | — | 1 | — | 5 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | 3 | — | 4 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 1 | 1 | 1 | 4 |
| Traumatic stress disorders | D040921 | — | — | — | 3 | — | 1 | — | 4 |
| Essential hypertension | D000075222 | — | I10 | — | — | — | 3 | — | 3 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | 1 | 2 | — | 3 |
| Pheochromocytoma | D010673 | — | — | — | — | 1 | 1 | 1 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary disease | D003327 | — | — | — | — | 1 | — | 2 | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 1 | — | 1 | 3 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | 1 | 2 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | — | 1 | 2 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | — | 1 | — | 1 | 2 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | — | 1 | 2 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 1 | — | 1 | 2 |
| Calculi | D002137 | — | — | — | — | 1 | — | 1 | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | — | 1 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 1 | — | — | 1 |
Show 4 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | 4 | 3 | — | — | — | 6 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 1 | 4 | — | — | — | 5 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 2 | — | — | — | 2 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | — | 1 | — | — | — | 1 |
| Dyssomnias | D020920 | — | — | — | 1 | — | — | — | 1 |
| Parasomnias | D020447 | — | G47.5 | — | 1 | — | — | — | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 3 | — | — | — | — | 3 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | — | — | — | 1 | 2 |
| Mydriasis | D015878 | HP_0011499 | H57.04 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 1 | — | — | — | — | 1 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urolithiasis | D052878 | — | N20-N23 | — | — | — | — | 2 | 2 |
| Urinary calculi | D014545 | — | — | — | — | — | — | 2 | 2 |
| Urinary retention | D016055 | HP_0000016 | R33 | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 1 | 1 |
| Microvascular angina | D017566 | — | — | — | — | — | — | 1 | 1 |
| Lithiasis | D020347 | — | — | — | — | — | — | 1 | 1 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | — | — | 1 | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | — | — | — | 1 | 1 |
| Cerebral small vessel diseases | D059345 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Doxazosin |
| INN | doxazosin |
| Description | Doxazosin is a member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist, an antineoplastic agent, a vasodilator agent and an antihyperplasia drug. It is a member of quinazolines, a N-acylpiperazine, a N-arylpiperazine, a benzodioxine, a monocarboxylic acid amide and an aromatic amine. |
| Classification | Small molecule |
| Drug class | antihypertensives (prazosin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 74191-85-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL707 |
| ChEBI ID | 4708 |
| PubChem CID | 3157 |
| DrugBank | DB00590 |
| UNII ID | NW1291F1W8 (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA1A
ADRA1A
ADRA1B
ADRA1B
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
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Variants
No data
Financial
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Cardura – Pfizer
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Estimated US medical usage
Doxazosin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Ibuprofen
Adverse Events
Top Adverse Reactions
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9,147 adverse events reported
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