Dorzolamide
Cosopt, Dorzolamide (dorzolamide) is a small molecule pharmaceutical. Dorzolamide was first approved as Trusopt on 1994-12-09. It is used to treat open-angle glaucoma in the USA. It is known to target carbonic anhydrase 12, carbonic anhydrase 1, carbonic anhydrase 7, and carbonic anhydrase 14.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Dorzolamide (discontinued: Dorzolamide, Trusopt)
CombinationsCosopt, Dorzolamide timolol (discontinued: Dorzolamide timolol)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dorzolamide hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRUSOPT | Merck & Co | N-020408 DISCN | 1994-12-09 | 1 products, RLD |
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Dorzolamide hydrochloride
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Timolol maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COSOPT | Thea Pharma | N-020869 RX | 1998-04-07 | 1 products, RLD, RS |
| COSOPT PF | Thea Pharma | N-202667 RX | 2012-02-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| brim-dor pf | unapproved drug other | 2018-05-08 |
| cosopt | New Drug Application | 2024-04-17 |
| cosopt pf | New Drug Application | 2024-01-08 |
| dorzolamide and timolol | ANDA | 2024-05-25 |
| dorzolamide hcl | ANDA | 2024-11-11 |
| dorzolamide hcl /timolol maleate | ANDA | 2013-01-29 |
| dorzolamide hcl and timolol maleate | ANDA | 2018-02-13 |
| dorzolamide hydrochloride | ANDA | 2025-09-26 |
| dorzolamide hydrochloride and timolol maleate | New Drug Application | 2025-09-10 |
| dorzolamide hydrochloride and timolol maleate ophthalmic solution | ANDA | 2024-11-06 |
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Clinical
Clinical Trials
87 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | — | 1 | 3 | 2 | 2 | 8 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | — | — | 3 | 2 | — | 5 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | — | 2 | 2 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 2 | 1 | — | 3 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low tension glaucoma | D057066 | EFO_1001022 | H40.12 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dorzolamide |
| INN | dorzolamide |
| Description | Dorzolamide is 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, an antihypertensive agent and an antiglaucoma drug. It is a sulfonamide and a member of thiophenes. |
| Classification | Small molecule |
| Drug class | carbonic anhydrase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21 |
Identifiers
| PDB | — |
| CAS-ID | 120279-96-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL218490 |
| ChEBI ID | 4702 |
| PubChem CID | 5284549 |
| DrugBank | DB00869 |
| UNII ID | 9JDX055TW1 (ChemIDplus, GSRS) |
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Dorzolamide
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Dorzolamide
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Timolol
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Safety
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8,812 adverse events reported
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