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Drug ReportsDorzolamide
Dorzolamide
Cosopt, Dorzolamide (dorzolamide) is a small molecule pharmaceutical. Dorzolamide was first approved as Trusopt on 1994-12-09. It is used to treat open-angle glaucoma in the USA. It is known to target carbonic anhydrase 12, carbonic anhydrase 1, carbonic anhydrase 7, and carbonic anhydrase 14.
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Drug
Target
Variants
Financial
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Safety
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Dorzolamide (discontinued: Dorzolamide, Trusopt)
Combinations
Cosopt, Dorzolamide timolol (discontinued: Dorzolamide timolol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dorzolamide hydrochloride
Tradename
Company
Number
Date
Products
TRUSOPTMerck & CoN-020408 DISCN1994-12-09
1 products, RLD
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Dorzolamide hydrochloride
+
Timolol maleate
Tradename
Company
Number
Date
Products
COSOPTThea PharmaN-020869 RX1998-04-07
1 products, RLD, RS
COSOPT PFThea PharmaN-202667 RX2012-02-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
brim-dor pfunapproved drug other2018-05-08
cosoptNew Drug Application2024-04-17
cosopt pfNew Drug Application2024-01-08
dorzolamide and timololANDA2024-05-25
dorzolamide hclANDA2022-12-31
dorzolamide hcl /timolol maleateANDA2013-01-29
dorzolamide hcl and timolol maleateANDA2018-02-13
dorzolamide hydrochlorideANDA2024-08-27
dorzolamide hydrochloride and timolol maleateANDA2024-11-01
dorzolamide hydrochloride and timolol maleate ophthalmicANDA2023-11-13
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
open-angle glaucomaEFO_0004190D005902H40.1
heart failureHP_0001635D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
angina pectorisEFO_0003913D000787I20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EC: Carbonic anhydrase inhibitors, antiglaucoma drugs and miotics
— S01EC03: Dorzolamide
HCPCS
No data
Clinical
Clinical Trials
81 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlaucomaD005901EFO_0000516H4031013311167
Ocular hypertensionD009798EFO_1001069H40.014919235
Open-angle glaucomaD005902EFO_0004190H40.1—6619434
HypertensionD006973EFO_0000537I10—4913127
Macular edemaD008269———21114
Eye diseasesD005128EFO_0003966H441——1—2
Exfoliation syndromeD017889EFO_0004235————1—1
Retinal degenerationD012162HP_0001105————1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EdemaD004487HP_0000969R60.9—21—13
Macular degenerationD008268EFO_0001365H35.30—21——2
Wet macular degenerationD057135EFO_0004683——21——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low tension glaucomaD057066EFO_1001022H40.12—1——12
Retinal vein occlusionD012170EFO_1001157H34.81—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Retinal detachmentD012163EFO_0005773H33.2————22
Diabetic retinopathyD003930EFO_0003770—————22
RetinoschisisD041441—H33.10————11
Retinal diseasesD012164HP_0000479H35.9————11
Scleral bucklingD012591——————11
Retinal perforationsD012167EFO_1001028—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDorzolamide
INNdorzolamide
Description
Dorzolamide is 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, an antihypertensive agent and an antiglaucoma drug. It is a sulfonamide and a member of thiophenes.
Classification
Small molecule
Drug classcarbonic anhydrase inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21
Identifiers
PDB—
CAS-ID120279-96-1
RxCUI—
ChEMBL IDCHEMBL218490
ChEBI ID4702
PubChem CID5284549
DrugBankDB00869
UNII ID9JDX055TW1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA4
CA4
Organism
Homo sapiens
Gene name
CA4
Gene synonyms
NCBI Gene ID
762
Protein name
carbonic anhydrase 4
Protein synonyms
CA-IV, Carbonate dehydratase IV, Carbonic anhydrase IV, carbonic dehydratase IV
Uniprot ID
Q6FHI7
Mouse ortholog
Car4 (12351)
carbonic anhydrase 4 (Q64444)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Dorzolamide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Dorzolamide
+
Timolol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,362 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,339 adverse events reported
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