Doribax(doripenem)
Doribax (doripenem) is a small molecule pharmaceutical. Doripenem was first approved as Doribax on 2007-10-12. It is used to treat bacterial infections, intraabdominal infections, and urinary tract infections in the USA. It has been approved in Europe to treat bacterial infections, bacterial pneumonia, cross infection, urinary tract infections, and ventilator-associated pneumonia.
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Commercial
Therapeutic Areas
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections | — | D001424 | A49 |
| intraabdominal infections | — | D059413 | — |
| urinary tract infections | EFO_0003103 | D014552 | N39.0 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J1267 | Injection, doripenem, 10 mg |
Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 1 | 5 | 2 | 2 | 10 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | 3 | 3 | 3 | — | 8 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 2 | 2 | 1 | 1 | 6 |
| Cross infection | D003428 | — | — | — | 1 | 1 | 1 | 1 | 4 |
| Bacterial infections | D001424 | — | A49 | 1 | 1 | — | 1 | — | 3 |
| Infections | D007239 | EFO_0000544 | — | — | — | 2 | 1 | — | 3 |
| Intraabdominal infections | D059413 | — | — | — | — | — | 1 | 1 | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | 1 | — | 2 |
| Febrile neutropenia | D064147 | — | — | — | — | — | 1 | — | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 2 | 1 | — | 1 | 4 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | 3 | — | — | 3 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | 3 | — | — | 3 |
| Abdominal abscess | D018784 | EFO_1001753 | — | — | 1 | 1 | — | — | 2 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | 2 | — | — | 2 |
| Cholecystitis | D002764 | HP_0001082 | K81 | — | — | 2 | — | — | 2 |
| Bacterial infections and mycoses | D001423 | — | — | — | — | 2 | — | — | 2 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | — | 2 | — | — | 2 |
| Healthcare-associated pneumonia | D000077299 | — | — | — | 1 | 1 | — | — | 1 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningitis | D008581 | HP_0001287 | G03 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Doripenem |
| INN | doripenem |
| Description | Doripenem is a member of carbapenems. |
| Classification | Small molecule |
| Drug class | antibacterial antibiotics, carbapenem derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](CNS(N)(=O)=O)C3)[C@H](C)[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 148016-81-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL491571 |
| ChEBI ID | — |
| PubChem CID | 73303 |
| DrugBank | — |
| UNII ID | BHV525JOBH (ChemIDplus, GSRS) |
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,030 adverse events reported
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