Dopamine
Dopamine (dopamine) is a small molecule pharmaceutical. Dopamine was first approved as Dopamine hydrochloride on 1982-01-01. It is used to treat bradycardia, heart block, hypotension, kidney diseases, and low cardiac output amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, D(1A) dopamine receptor, D(1B) dopamine receptor, and D(2) dopamine receptor. In addition, it is known to target glucose-dependent insulinotropic receptor, transient receptor potential cation channel subfamily M member 8, and transient receptor potential cation channel subfamily V member 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Dopamine (discontinued: Dopamine, Intropin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dopamine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DOPAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER | Baxter | N-019615 RX | 1987-03-27 | 4 products, RLD, RS |
| DOPAMINE HYDROCHLORIDE | Hospira | N-018132 RX | 1982-01-01 | 4 products, RLD, RS |
| DOPAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER | Hospira | N-018826 RX | 1983-09-30 | 3 products, RLD, RS |
Show 11 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| dopamine hci | New Drug Application | 2024-02-22 |
| dopamine hci in 5% dextrose | New Drug Application | 2024-01-27 |
| dopamine hydrochloride | New Drug Application | 2024-11-04 |
| dopamine hydrochloride and dextrose | New Drug Application | 2020-11-11 |
| dopamine hydrochloride in dextrose | New Drug Application | 2024-11-05 |
| parcopa | 2007-11-05 | |
| sinemet | New Drug Application | 2022-06-01 |
Indications
FDA
EMA
Agency Specific
FDA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01C: Cardiac stimulants excl. cardiac glycosides
— C01CA: Adrenergic and dopaminergic cardiac stimulants
— C01CA04: Dopamine
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BC: Dopamine agonists
HCPCS
Code | Description |
|---|---|
| J1265 | Injection, dopamine hcl, 40 mg |
Clinical
Clinical Trials
4910 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | 109 | 95 | 215 | 243 | 120 | 758 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 106 | 142 | 138 | 81 | 177 | 607 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 27 | 57 | 116 | 133 | 57 | 378 |
| Depression | D003863 | — | F33.9 | 21 | 53 | 112 | 130 | 57 | 362 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | 14 | 46 | 78 | 126 | 62 | 312 |
| Psychotic disorders | D011618 | — | F20.81 | 25 | 19 | 57 | 102 | 51 | 249 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 17 | 34 | 83 | 82 | 37 | 246 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 12 | 22 | 93 | 65 | 34 | 219 |
| Hyperkinesis | D006948 | HP_0000752 | — | 6 | 32 | 57 | 81 | 47 | 214 |
| Healthy volunteers/patients | — | — | — | 149 | 7 | 3 | 22 | 33 | 210 |
Show 410 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 7 | 11 | 5 | — | 1 | 20 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 7 | 11 | 5 | — | 1 | 20 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | 2 | 9 | 6 | — | 2 | 16 |
| Movement disorders | D009069 | HP_0100022 | — | 5 | 9 | 1 | — | 5 | 15 |
| Glioblastoma | D005909 | EFO_0000515 | — | 6 | 6 | 1 | — | 2 | 14 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 6 | 6 | 1 | — | 1 | 12 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 2 | 3 | 6 | — | 2 | 11 |
| Covid-19 | D000086382 | — | — | 1 | 1 | 5 | — | 4 | 10 |
| Shy-drager syndrome | D012791 | EFO_1001050 | — | 3 | 1 | 2 | — | 5 | 10 |
| Multiple system atrophy | D019578 | — | — | 3 | 1 | 2 | — | 5 | 10 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | 3 | 6 | — | — | 3 | 9 |
| Schizotypal personality disorder | D012569 | — | F21 | 4 | 3 | — | — | 2 | 8 |
| Gambling | D005715 | EFO_1001926 | F63.0 | — | 3 | — | — | 4 | 7 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | 1 | 2 | — | — | 4 | 7 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 5 | — | — | 1 | 6 |
| Bulimia nervosa | D052018 | EFO_0005204 | F50.2 | — | 1 | — | — | 5 | 6 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | 2 | — | — | 3 | 5 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | 1 | 4 | — | — | 1 | 5 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | 5 | — | — | — | 5 |
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | 2 | — | — | 2 | 4 |
Show 134 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | 2 | — | — | — | 12 | 14 |
| Therapeutic equivalency | D013810 | — | — | 11 | — | — | — | 1 | 12 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | 1 | — | — | — | 4 | 5 |
| Motivation | D009042 | — | — | 2 | — | — | — | 3 | 5 |
| Chest pain | D002637 | HP_0100749 | R07.9 | 1 | — | — | — | 3 | 4 |
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | 1 | — | — | — | 2 | 3 |
| Deep brain stimulation | D046690 | — | — | 1 | — | — | — | 2 | 3 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | 2 | 3 |
| Root caries | D017213 | EFO_1001163 | — | 1 | — | — | — | 2 | 3 |
| Pheochromocytoma | D010673 | — | — | 1 | — | — | — | 1 | 2 |
Show 46 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pathologic constriction | D003251 | — | — | — | — | — | — | 6 | 6 |
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 5 | 5 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | — | — | 5 | 5 |
| Rem sleep behavior disorder | D020187 | EFO_0007462 | G47.52 | — | — | — | — | 5 | 5 |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | — | — | 4 | 4 |
| Ventricular dysfunction | D018754 | — | — | — | — | — | — | 4 | 4 |
| Femoral fractures | D005264 | — | S72 | — | — | — | — | 4 | 4 |
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | — | 4 | 4 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 3 | 3 |
| Tinnitus | D014012 | HP_0000360 | H93.1 | — | — | — | — | 3 | 3 |
Show 236 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dopamine |
| INN | dopamine |
| Description | Dopamine is catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. It has a role as a cardiotonic drug, a beta-adrenergic agonist, a dopaminergic agent, a sympathomimetic agent, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate base of a dopaminium(1+). |
| Classification | Small molecule |
| Drug class | dopaminergics (butopamine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCc1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 51-61-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL59 |
| ChEBI ID | 18243 |
| PubChem CID | 681 |
| DrugBank | DB00988 |
| UNII ID | VTD58H1Z2X (ChemIDplus, GSRS) |
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Safety
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6,267 adverse events reported
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