Dopamine
Dopamine (dopamine) is a small molecule pharmaceutical. Dopamine was first approved as Dopamine hydrochloride on 1982-01-01. It is used to treat bradycardia, heart block, hypotension, kidney diseases, and low cardiac output amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, D(1A) dopamine receptor, D(1B) dopamine receptor, and D(2) dopamine receptor. In addition, it is known to target glucose-dependent insulinotropic receptor, transient receptor potential cation channel subfamily M member 8, and transient receptor potential cation channel subfamily V member 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Dopamine (discontinued: Dopamine, Intropin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dopamine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DOPAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER | Baxter | N-019615 RX | 1987-03-27 | 4 products, RLD, RS |
| DOPAMINE HYDROCHLORIDE | Hospira | N-018132 RX | 1982-01-01 | 4 products, RLD, RS |
| DOPAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER | Hospira | N-018826 RX | 1983-09-30 | 3 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| dopamine hci | New Drug Application | 2024-02-22 |
| dopamine hci in 5% dextrose | New Drug Application | 2024-01-27 |
| dopamine hydrochloride | New Drug Application | 2024-12-18 |
| dopamine hydrochloride and dextrose | New Drug Application | 2020-11-11 |
| dopamine hydrochloride in dextrose | New Drug Application | 2024-11-25 |
| parcopa | 2007-11-05 | |
| sinemet | New Drug Application | 2022-06-01 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1265 | Injection, dopamine hcl, 40 mg |
Clinical
Clinical Trials
4952 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | 1 | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | — | 1 | — | 1 |
| Psychomotor agitation | D011595 | — | — | — | — | — | 1 | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | 1 | — | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 1 | — | 1 |
| Hypokinesia | D018476 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Shock | D012769 | — | R57.1 | — | 1 | 1 | — | 1 | 2 |
| Cardiogenic shock | D012770 | — | R57.0 | — | 1 | 1 | — | 1 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 1 | — | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | — | — | — | 2 |
| Dyskinesias | D020820 | — | G24 | — | 1 | — | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | — | 1 | — | — | — | 1 |
| Acute kidney injury | D058186 | — | N17 | — | 1 | — | — | — | 1 |
| Cardiac surgical procedures | D006348 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dopamine |
| INN | dopamine |
| Description | Dopamine is catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. It has a role as a cardiotonic drug, a beta-adrenergic agonist, a dopaminergic agent, a sympathomimetic agent, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate base of a dopaminium(1+). |
| Classification | Small molecule |
| Drug class | dopaminergics (butopamine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCc1ccc(O)c(O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 51-61-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL59 |
| ChEBI ID | 18243 |
| PubChem CID | 681 |
| DrugBank | DB00988 |
| UNII ID | VTD58H1Z2X (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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1,473 adverse events reported
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