Therapeutic Area | MeSH |
---|---|
nervous system diseases | D009422 |
mental disorders | D001523 |
Brand Name | Status | Last Update |
---|---|---|
adlarity | New Drug Application | 2023-02-17 |
aricept | New Drug Application | 2022-11-15 |
donepezil | ANDA | 2025-01-07 |
donepezil donepezil hydrochloride | ANDA | 2019-10-09 |
donepezil hydrochloride | ANDA | 2025-01-31 |
donepezil hydrochloride donepezil hyrochloride | ANDA | 2019-02-16 |
memantine and donepezil hydrochlorides | ANDA | 2025-01-01 |
memantine and donepezil hydrochlorides extended-release | ANDA | 2025-02-06 |
namzaric | New Drug Application | 2024-05-13 |
tradename | New Drug Application | 2014-12-23 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
alzheimer disease | EFO_0000249 | D000544 | F03 |
Expiration | Code | ||
---|---|---|---|
DONEPEZIL HYDROCHLORIDE, ADLARITY, CORIUM | |||
2025-03-11 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Donepezil Hydrochloride, Adlarity, Corium | |||
10966936 | 2038-08-11 | DP | U-3334 |
10835499 | 2038-05-20 | DP | U-3334 |
11648214 | 2037-09-23 | DP | U-3334 |
9993466 | 2037-07-26 | DP | |
10016372 | 2037-07-26 | U-3334 | |
10300025 | 2037-07-26 | DP | |
10307379 | 2037-07-26 | DP | |
11103463 | 2037-07-26 | U-3334 | |
11679086 | 2037-05-26 | U-3334 | |
Donepezil Hydrochloride / Memantine Hydrochloride, Namzaric, Abbvie | |||
8058291 | 2029-12-05 | U-1641 | |
8039009 | 2029-03-24 | U-1641 | |
8168209 | 2025-11-22 | DP | |
8173708 | 2025-11-22 | U-1641 | |
8283379 | 2025-11-22 | U-1641 | |
8293794 | 2025-11-22 | DP | |
8329752 | 2025-11-22 | DP | |
8338485 | 2025-11-22 | DP | |
8338486 | 2025-11-22 | U-1641 | |
8362085 | 2025-11-22 | U-1641 | |
8580858 | 2025-11-22 | U-1641 | |
8598233 | 2025-11-22 | DP | |
Donepezil Hydrochloride, Aricept, Eisai Inc | |||
8481565 | 2026-10-04 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 4 | 6 | 10 | 8 | 28 |
Dementia | D003704 | EFO_0003862 | F03 | — | 4 | 8 | 3 | 3 | 18 |
Cognitive dysfunction | D060825 | — | G31.84 | — | 3 | 2 | 2 | — | 7 |
Lewy body disease | D020961 | EFO_0006792 | G31.83 | — | 2 | 1 | 1 | 1 | 5 |
Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | — | 2 | 1 | — | 3 |
Vascular dementia | D015140 | — | F01 | — | — | 1 | 1 | — | 2 |
Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 1 | — | 1 |
Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | — | 1 |
Memory disorders | D008569 | — | — | — | — | — | 1 | — | 1 |
Amnesia | D000647 | EFO_1001454 | F44.0 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Down syndrome | D004314 | EFO_0001064 | Q90 | — | 3 | 2 | — | — | 5 |
Syndrome | D013577 | — | — | — | 3 | 2 | — | — | 5 |
Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 2 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
Headache | D006261 | — | R51 | — | 1 | — | — | — | 1 |
Cadasil | D046589 | Orphanet_136 | I67.850 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Mixed dementias | D000093902 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Donepezil |
INN | donepezil |
Description | Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor. It contains a (R)-donepezil and a (S)-donepezil. It is a conjugate base of a donepezil (1+). |
Classification | Small molecule |
Drug class | acetylcholinesterase inhibitors used in the treatment of Alzheimer's disease |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 |
PDB | — |
CAS-ID | 120014-06-4 |
RxCUI | — |
ChEMBL ID | CHEMBL502 |
ChEBI ID | 53289 |
PubChem CID | 3152 |
DrugBank | DB00843 |
UNII ID | 8SSC91326P (ChemIDplus, GSRS) |