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Drug ReportsDomperidone
Domperidone
Domperidone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Agency Specific
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03F: Propulsives
— A03FA: Propulsives
— A03FA03: Domperidone
HCPCS
No data
Clinical
Clinical Trials
81 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VomitingD014839—R11.1——1——1
GastroenteritisD005759EFO_1001463K52.9——1——1
Indications Phases 2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
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Ph 2
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Healthy volunteers/patients———2————2
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
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Sudden death cardiacD016757EFO_0004278—————22
DeathD003643PATO_0001422—————22
Sudden deathD003645——————11
Cardiac arrhythmiasD001145EFO_0004269I49.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDomperidone
INNdomperidone
Description
Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as an antiemetic and a dopaminergic antagonist. It is a member of benzimidazoles and a heteroarylpiperidine.
Classification
Small molecule
Drug classantipsychotics (risperidone type)
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Structure (InChI/SMILES or Protein Sequence)
O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1
Identifiers
PDB—
CAS-ID57808-66-9
RxCUI—
ChEMBL IDCHEMBL219916
ChEBI ID31515
PubChem CID3151
DrugBankDB01184
UNII ID5587267Z69 (ChemIDplus, GSRS)
Target
Agency Approved
DRD3
DRD3
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,921 adverse events reported
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