Domperidone
Domperidone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor.
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Clinical Trials
81 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | 2 | 3 | 1 | 13 | 19 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | 3 | 4 | 6 | 13 |
| Vomiting | D014839 | — | R11.1 | — | — | 5 | 1 | 4 | 10 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 2 | — | 1 | 3 | 7 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | 1 | — | 2 | 2 | 1 | 6 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 2 | — | 1 | 1 | 4 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 1 | — | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | 1 | — | 1 |
| Respiratory aspiration of gastric contents | D063466 | — | — | — | — | — | 1 | — | 1 |
Show 2 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastrointestinal diseases | D005767 | — | — | — | — | 1 | — | 4 | 5 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | — | 1 | — | 4 | 5 |
| Nausea | D009325 | — | R11.0 | — | — | 1 | — | 2 | 3 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | 2 | — | 1 | 3 |
| Sclerosis | D012598 | — | — | — | 2 | 1 | — | — | 3 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | 1 | — | 1 | 2 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | — | 1 | — | 1 | 2 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | — | — | 2 | — | — | 2 |
| Consciousness disorders | D003244 | — | — | — | 2 | 1 | — | — | 2 |
| Esophagitis | D004941 | HP_0100633 | K20 | — | — | 1 | — | 1 | 2 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lactation | D007774 | — | — | — | 1 | — | — | 1 | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | — | 1 |
| Edema | D004487 | — | R60.9 | — | 1 | — | — | — | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | — | 1 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast feeding | D001942 | — | — | 1 | — | — | — | 1 | 2 |
| Placebos | D010919 | — | — | 1 | — | — | — | — | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Shy-drager syndrome | D012791 | EFO_1001050 | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Multiple system atrophy | D019578 | — | — | 1 | — | — | — | — | 1 |
| Atrophy | D001284 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | — | — | 4 | 4 |
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 4 | 4 |
| Constipation | D003248 | — | K59.0 | — | — | — | — | 3 | 3 |
| Capsule endoscopy | D053704 | — | — | — | — | — | — | 2 | 2 |
| Localized scleroderma | D012594 | EFO_1001361 | L94.0 | — | — | — | — | 1 | 1 |
| Memory consolidation | D000069077 | — | — | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Sudden death | D003645 | — | — | — | — | — | — | 1 | 1 |
| Esophageal achalasia | D004931 | — | K22.0 | — | — | — | — | 1 | 1 |
| Abdominal pain | D015746 | EFO_0003766 | R10.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Domperidone |
| INN | domperidone |
| Description | Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as an antiemetic and a dopaminergic antagonist. It is a member of benzimidazoles and a heteroarylpiperidine. |
| Classification | Small molecule |
| Drug class | antipsychotics (risperidone type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 57808-66-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL219916 |
| ChEBI ID | 31515 |
| PubChem CID | 3151 |
| DrugBank | DB01184 |
| UNII ID | 5587267Z69 (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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5,921 adverse events reported
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