Divalproex sodium
Depakote, Divalproex (divalproex sodium) is a small molecule pharmaceutical. Divalproex sodium was first approved as Depakote on 1983-03-10. It is used to treat absence epilepsy, bipolar disorder, complex partial epilepsy, epilepsy, and epilepsy amongst others in the USA. It is known to target histone deacetylase 1.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Depakote, Divalproex (discontinued: Depakote cp, Divalproex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| depakote | New Drug Application | 2024-03-18 |
| depakote er | 2008-04-07 | |
| divalproex sodium | ANDA | 2024-11-15 |
| divalproex sodium delayed-release | 2008-12-04 | |
| divalproex sodium er | ANDA | 2023-04-03 |
| divalproex sodium extended-release | NDA authorized generic | 2015-01-03 |
| divalproex sodiumdelayed-release | ANDA | 2013-12-30 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
425 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 8 | 14 | 42 | 38 | 13 | 109 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 10 | 8 | 8 | 21 | 23 | 66 |
| Depression | D003863 | — | F33.9 | 1 | 5 | 10 | 6 | 1 | 22 |
| Healthy volunteers/patients | — | — | — | 17 | — | — | 3 | — | 20 |
| Leukemia | D007938 | — | C95 | 8 | 14 | — | 1 | 1 | 19 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 2 | 5 | 9 | 5 | — | 19 |
| Seizures | D012640 | HP_0002069 | G40.4 | 2 | 1 | 6 | 4 | 5 | 17 |
| Syndrome | D013577 | — | — | 1 | 14 | 1 | 1 | — | 15 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 2 | 1 | 3 | 5 | 4 | 15 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | 6 | 4 | 1 | 12 |
Show 72 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Status epilepticus | D013226 | EFO_0008526 | G41 | — | 2 | 3 | — | 5 | 10 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 3 | 1 | — | — | 6 |
| Muscular atrophy | D009133 | HP_0003202 | — | 2 | 3 | 1 | — | 1 | 6 |
| Spinal muscular atrophy | D009134 | EFO_0003823 | G12.1 | 2 | 3 | 1 | — | 1 | 6 |
| Atrophy | D001284 | — | — | 2 | 3 | 1 | — | 1 | 6 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | 2 | 1 | — | — | 4 |
| Headache | D006261 | HP_0002315 | R51 | — | — | 1 | — | 3 | 4 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | — | 1 | — | — | 3 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 2 | — | 1 | — | — | 3 |
| Diffuse intrinsic pontine glioma | D000080443 | — | — | — | 2 | 1 | — | — | 3 |
Show 26 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 14 | 2 | — | — | — | 15 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 12 | — | — | — | 13 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 5 | 10 | — | — | — | 11 |
| Myeloid leukemia | D007951 | — | C92 | 4 | 10 | — | — | — | 11 |
| Preleukemia | D011289 | — | — | 1 | 11 | — | — | — | 11 |
| Carcinoma | D002277 | — | C80.0 | 5 | 2 | — | — | — | 7 |
| Recurrence | D012008 | — | — | 4 | 1 | — | — | — | 5 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 3 | — | — | — | 5 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | 2 | — | — | 1 | 5 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 2 | — | — | 1 | 5 |
Show 84 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 4 | — | — | — | 1 | 5 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 3 | — | — | — | — | 3 |
| Drug interactions | D004347 | — | — | 3 | — | — | — | — | 3 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 2 | — | — | — | — | 2 |
| Nasopharyngeal neoplasms | D009303 | — | — | 2 | — | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Hemorrhagic shock | D012771 | — | — | 2 | — | — | — | — | 2 |
| Mantle-cell lymphoma | D020522 | — | — | 1 | — | — | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | — | — | — | 1 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | — | — | — | — | 1 |
Show 30 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 2 | 2 |
| Secondary headache disorders | D051271 | — | — | — | — | — | — | 2 | 2 |
| Prescription drug overuse | D000067490 | — | — | — | — | — | — | 2 | 2 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | — | — | — | — | 1 | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 1 | 1 |
| Financial stress | D000086522 | — | — | — | — | — | — | 1 | 1 |
| Photophobia | D020795 | HP_0000613 | H53.14 | — | — | — | — | 1 | 1 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | — | — | — | — | 1 | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | — | 1 | 1 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | — | — | — | 1 | 1 |
Show 27 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Divalproex sodium |
| INN | valproate semisodium |
| Description | Valproic acid is a branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. It has a role as an anticonvulsant, a GABA agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, a teratogenic agent, a psychotropic drug, a neuroprotective agent and an antimanic drug. It is a branched-chain saturated fatty acid and a branched-chain fatty acid. It is functionally related to a valeric acid. It is a conjugate acid of a valproate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+] |
Identifiers
| PDB | — |
| CAS-ID | 76584-70-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105613 |
| ChEBI ID | 4667 |
| PubChem CID | 3121 |
| DrugBank | DB00510 |
| UNII ID | 644VL95AO6 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HDAC1
HDAC1
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 56,169 documents
View more details
Safety
Black-box Warning
Black-box warning for: Depakote, Depakote er, Divalproex sodium, Divalproex sodium delayed-release, Divalproex sodium er, Divalproex sodium extended-release, Divalproex sodiumdelayed-release
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
63,171 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use