Therapeutic Area | MeSH |
---|---|
nervous system diseases | D009422 |
mental disorders | D001523 |
Brand Name | Status | Last Update |
---|---|---|
depakote | New Drug Application | 2023-09-27 |
depakote er | 2008-04-07 | |
divalproex sodium | ANDA | 2024-01-18 |
divalproex sodium delayed-release | 2008-12-04 | |
divalproex sodium er | ANDA | 2023-04-03 |
divalproex sodium extended-release | NDA authorized generic | 2015-01-03 |
divalproex sodiumdelayed-release | ANDA | 2013-12-30 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 5 | 5 | 22 | 30 | 7 | 68 |
Epilepsy | D004827 | EFO_0000474 | G40.9 | 7 | 2 | 3 | 7 | 9 | 27 |
Healthy volunteers/patients | — | — | — | 17 | — | — | 3 | — | 20 |
Schizophrenia | D012559 | EFO_0000692 | F20 | 2 | 1 | 2 | 5 | 2 | 12 |
Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 3 | 3 | 1 | 1 | 7 |
Dementia | D003704 | EFO_0003862 | F03 | 1 | — | 2 | 2 | — | 5 |
Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | 1 | 2 | — | 5 |
Autistic disorder | D001321 | HP_0000717 | F84.0 | — | 3 | 1 | 1 | — | 5 |
Glioma | D005910 | EFO_0000520 | — | 1 | 2 | — | 1 | — | 4 |
Mania | D000087122 | — | F30 | — | — | — | 4 | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Seizures | D012640 | HP_0002069 | G40.4 | 1 | — | 3 | — | 2 | 6 |
Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | 5 | — | — | 6 |
Glioblastoma | D005909 | EFO_0000515 | — | 2 | 2 | 1 | — | — | 5 |
Status epilepticus | D013226 | EFO_0008526 | G41 | — | 2 | 1 | — | 2 | 5 |
Spinal muscular atrophy | D009134 | EFO_0003823 | G12.1 | 1 | 2 | 1 | — | — | 4 |
Astrocytoma | D001254 | EFO_0000271 | — | 1 | 1 | 1 | — | — | 3 |
Diffuse intrinsic pontine glioma | D000080443 | — | — | — | 1 | 1 | — | — | 2 |
Neuroepithelial neoplasms | D018302 | — | — | — | 1 | 1 | — | — | 2 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | 1 | — | — | 2 |
Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | 1 | 1 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 13 | 2 | — | — | — | 14 |
Myelodysplastic syndromes | D009190 | — | D46 | 2 | 8 | — | — | — | 9 |
Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 8 | — | — | — | 9 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | 2 | — | — | 1 | 5 |
Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 3 | — | — | — | 5 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | 3 | 1 | — | — | — | 4 |
Leukemia | D007938 | — | C95 | 1 | 3 | — | — | — | 3 |
Acute kidney injury | D058186 | HP_0001919 | N17 | — | 2 | — | — | 1 | 3 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | — | 2 |
Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 2 | 1 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Sarcoma | D012509 | — | — | 3 | — | — | — | 1 | 4 |
Drug interactions | D004347 | — | — | 3 | — | — | — | — | 3 |
Nasopharyngeal carcinoma | D000077274 | — | — | 2 | — | — | — | — | 2 |
Nasopharyngeal neoplasms | D009303 | — | — | 2 | — | — | — | — | 2 |
Central nervous system neoplasms | D016543 | — | — | 2 | — | — | — | — | 2 |
Traumatic brain injuries | D000070642 | — | S06 | 1 | — | — | — | 1 | 2 |
Hemorrhagic shock | D012771 | — | — | 2 | — | — | — | — | 2 |
Mantle-cell lymphoma | D020522 | — | C83.1 | 1 | — | — | — | — | 1 |
Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | — | — | — | 1 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 1 | 1 |
Metabolic bone diseases | D001851 | HP_0000938 | — | — | — | — | — | 1 | 1 |
Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | — | 1 | 1 |
Insulin resistance | D007333 | HP_0000855 | E88.819 | — | — | — | — | 1 | 1 |
Body composition | D001823 | — | — | — | — | — | — | 1 | 1 |
Alveolar bone loss | D016301 | — | — | — | — | — | — | 1 | 1 |
Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 1 | 1 |
Nocturnal enuresis | D053206 | — | N39.44 | — | — | — | — | 1 | 1 |
Borderline personality disorder | D001883 | HP_0012076 | F60.3 | — | — | — | — | 1 | 1 |
Cluster headache | D003027 | HP_0012199 | G44.00 | — | — | — | — | 1 | 1 |
Drug common name | Divalproex sodium |
INN | valproate semisodium |
Description | Valproic acid is a branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. It has a role as an anticonvulsant, a GABA agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, a teratogenic agent, a psychotropic drug, a neuroprotective agent and an antimanic drug. It is a branched-chain saturated fatty acid and a branched-chain fatty acid. It is functionally related to a valeric acid. It is a conjugate acid of a valproate. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+] |
PDB | — |
CAS-ID | 76584-70-8 |
RxCUI | — |
ChEMBL ID | CHEMBL2105613 |
ChEBI ID | 4667 |
PubChem CID | 3121 |
DrugBank | DB00510 |
UNII ID | 644VL95AO6 (ChemIDplus, GSRS) |