Disulfiram
Disulfiram (disulfiram) is a small molecule pharmaceutical. Disulfiram was first approved as Antabuse on 1982-01-01. It is used to treat alcoholism in the USA. It is known to target aldehyde dehydrogenase, mitochondrial.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| chemically-induced disorders | D064419 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Disulfiram (discontinued: Antabuse, Disulfiram)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antabuse | ANDA | 2012-04-18 |
| disulfiram | ANDA | 2024-08-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alcoholism | EFO_0003829 | D000437 | F10.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07B: Drugs used in addictive disorders
— N07BB: Drugs used in alcohol dependence
— N07BB01: Disulfiram
P: Antiparasitic products, insecticides and repellents
— P03: Ectoparasiticides, incl. scabicides, insecticides and repellents
— P03A: Ectoparasiticides, incl. scabicides
— P03AA: Sulfur containing product ectoparasiticides
— P03AA04: Disulfiram
— P03AA54: Disulfiram, combinations
HCPCS
No data
Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 2 | 3 | — | 4 | 6 | 14 |
| Cocaine-related disorders | D019970 | — | F14 | 3 | 7 | — | 1 | 1 | 11 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | — | — | 1 | 4 | 5 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | 6 | 1 | — | — | 8 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | 1 | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | 1 | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 2 | — | — | 2 | 5 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 3 | — | — | 1 | 4 |
| Alcohol-related disorders | D019973 | — | F10 | 2 | 3 | — | — | — | 4 |
| Melanoma | D008545 | — | — | 2 | 2 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | 1 | 3 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 2 | 1 | — | — | — | 2 |
| Covid-19 | D000086382 | — | — | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Retinal degeneration | D012162 | HP_0001105 | — | 2 | 1 | — | — | — | 2 |
| Retinal dystrophies | D058499 | HP_0000556 | — | 2 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | 1 | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | — | 1 |
| Body weight | D001835 | EFO_0004338 | — | 1 | — | — | — | — | 1 |
| Stargardt disease | D000080362 | — | H35.53 | 1 | — | — | — | — | 1 |
| Retinitis pigmentosa | D012174 | HP_0000580 | H35.52 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 1 | 1 |
| Ankle injuries | D016512 | — | S93.4 | — | — | — | — | 1 | 1 |
| Alcoholic intoxication | D000435 | — | — | — | — | — | — | 1 | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Disulfiram |
| INN | disulfiram |
| Description | Disulfiram is an organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. It has a role as an EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor, an angiogenesis inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.1 (carboxylesterase) inhibitor, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a fungicide, an apoptosis inducer, a NF-kappaB inhibitor, an antineoplastic agent and a ferroptosis inducer. It is an organic disulfide and an organosulfur acaricide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(=S)SSC(=S)N(CC)CC |
Identifiers
| PDB | — |
| CAS-ID | 97-77-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL964 |
| ChEBI ID | 4659 |
| PubChem CID | 3117 |
| DrugBank | DB00822 |
| UNII ID | TR3MLJ1UAI (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ALDH2
ALDH2
Organism
Homo sapiens
Gene name
ALDH2
Gene synonyms
ALDM
NCBI Gene ID
Protein name
aldehyde dehydrogenase, mitochondrial
Protein synonyms
acetaldehyde dehydrogenase 2, aldehyde dehydrogenase 2 family (mitochondrial), ALDH class 2, ALDH-E2, ALDHI, epididymis secretory sperm binding protein, liver mitochondrial ALDH, nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Uniprot ID
Mouse ortholog
Aldh2 (11669)
aldehyde dehydrogenase, mitochondrial (P47738)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Disulfiram
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,504 documents
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Safety
Black-box Warning
Black-box warning for: Antabuse, Disulfiram
Adverse Events
Top Adverse Reactions
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1,031 adverse events reported
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