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Drug ReportsDiquafosol
Diquafosol
Diquafosol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target P2Y purinoceptor 4 and P2Y purinoceptor 2.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
32 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Keratoconjunctivitis siccaD007638EFO_1000906—————22
Dry eye syndromesD015352—H04.12————22
CataractD002386EFO_0001059H26.9————11
Capsule opacificationD058442—H26.4————11
Diabetic retinopathyD003930EFO_0003770—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDiquafosol
INNdiquafosol
Description
P(1),P(4)-bis(uridin-5'-yl) tetraphosphate is a pyrimidine ribonucleoside 5'-tetraphosphate compound having 5'-uridinyl residues at the P(1)- and P(4)-positions. It has a role as a P2Y2 receptor agonist and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-tetraphosphate and a uridine 5'-phosphate.
Classification
Small molecule
Drug classphosphoro-derivatives
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Structure (InChI/SMILES or Protein Sequence)
O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Identifiers
PDB—
CAS-ID59985-21-6
RxCUI—
ChEMBL IDCHEMBL221326
ChEBI ID27791
PubChem CID148197
DrugBank—
UNII ID7828VC80FJ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RY4
P2RY4
P2RY2
P2RY2
Organism
Homo sapiens
Gene name
P2RY4
Gene synonyms
NRU
NCBI Gene ID
Protein name
P2Y purinoceptor 4
Protein synonyms
P2P, pyrimidinergic receptor P2Y, G-protein coupled, 4, UNR, Uridine nucleotide receptor
Uniprot ID
Mouse ortholog
P2ry4 (57385)
P2Y purinoceptor 4 (Q9JJS7)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 632 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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15 adverse events reported
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