Dipyridamole
Dipyridamole, Persantine (dipyridamole) is a small molecule pharmaceutical. Dipyridamole was first approved as Persantine on 1986-12-22. The pharmaceutical is active against equilibrative nucleoside transporter 1. In addition, it is known to target high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, equilibrative nucleoside transporter 4, 3',5'-cyclic-AMP phosphodiesterase 7B, and high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A.
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Commercial
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Trade Name
FDA
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Persantine (generic drugs available since 1990-10-03)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AGGRENOX | Boehringer Ingelheim | N-020884 DISCN | 1999-11-22 | 1 products, RLD |
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Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PERSANTINE | Boehringer Ingelheim | N-012836 RX | 1986-12-22 | 3 products, RLD |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aggrenox | New Drug Application | 2016-08-06 |
| aspirin and dipyridamole | ANDA | 2023-12-26 |
| aspirin and dipyridamole extended release | ANDA | 2019-01-18 |
| aspirin and extended - release dipyridamole capsules, 25 mg / 200 mg | ANDA | 2022-12-15 |
| aspirin and extended-release dipyridamole | ANDA | 2024-01-09 |
| aspirin-dipyridamole | ANDA | 2023-05-15 |
| asprin and extended-release dipyridamole | ANDA | 2021-05-31 |
| dipyridamole | ANDA | 2023-10-13 |
| dipyridamole dipyridamole | ANDA | 2018-12-14 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
| J1245 | Injection, dipyridamole, per 10 mg |
Clinical
Clinical Trials
103 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 14 | 1 | — | 1 | — | 16 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | 1 | 3 | 7 | 12 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 2 | 2 | 2 | 5 | 11 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 4 | 2 | 2 | 9 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | 3 | 5 | 8 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 2 | 2 | 1 | 6 |
| Coronary disease | D003327 | — | — | — | 1 | 2 | 1 | 2 | 6 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 3 | 1 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | 2 | — | 3 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | 2 | 1 | 3 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 2 | — | 1 | 4 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | 2 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 2 | 1 | — | — | 3 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 1 | — | — | 1 |
| Patent foramen ovale | D054092 | HP_0001655 | Q21.12 | — | — | 1 | — | — | 1 |
| Internal carotid artery dissection | D020215 | — | — | — | — | 1 | — | — | 1 |
| Vertebral artery dissection | D020217 | — | I77.74 | — | — | 1 | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | 1 | — | — | 1 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | — | — | 4 | 5 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 4 | — | — | — | 4 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | 1 | — | — | 3 | 4 |
| Carotid stenosis | D016893 | — | — | — | 1 | — | — | 1 | 2 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | 1 | 1 | — | — | 1 | 2 |
| Cerebral hemorrhage | D002543 | — | — | — | 1 | — | — | — | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | 1 | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary angiography | D017023 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary embolism | D011655 | HP_0002204 | I26 | — | — | — | — | 4 | 4 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Myocardial perfusion imaging | D055414 | — | — | — | — | — | — | 2 | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | — | — | — | 1 | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 1 | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 1 | 1 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | — | — | — | 1 | 1 |
| Hyperemia | D006940 | EFO_0003822 | H34.82 | — | — | — | — | 1 | 1 |
Show 14 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dipyridamole |
| INN | dipyridamole |
| Description | Dipyridamole is a pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. It has a role as an adenosine phosphodiesterase inhibitor, an EC 3.5.4.4 (adenosine deaminase) inhibitor, a platelet aggregation inhibitor and a vasodilator agent. It is a member of piperidines, a pyrimidopyrimidine, a tertiary amino compound and a tetrol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 58-32-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL932 |
| ChEBI ID | 4653 |
| PubChem CID | 3108 |
| DrugBank | DB00975 |
| UNII ID | 64ALC7F90C (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
PDE7B
PDE7B
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
PDE7B
Gene synonyms
NCBI Gene ID
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Protein synonyms
high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase, rolipram-insensitive phosphodiesterase type 7
Uniprot ID
Mouse ortholog
Pde7b (29863)
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Q9QXQ1)
Variants
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Financial
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Estimated US medical usage
Dipyridamole
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Aspirin
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Dipyridamole
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Trends
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Additional graphs summarizing 16,464 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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3,143 adverse events reported
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