Dipyridamole
Dipyridamole (dipyridamole) is a small molecule pharmaceutical. Dipyridamole was first approved as Persantine on 1986-12-22. The pharmaceutical is active against equilibrative nucleoside transporter 1. In addition, it is known to target high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, equilibrative nucleoside transporter 4, 3',5'-cyclic-AMP phosphodiesterase 7B, and high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Dipyridamole (discontinued: Dipyridamole, Persantine)
CombinationsAspirin dipyridamole (discontinued: Aggrenox, Aspirin dipyridamole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AGGRENOX | Boehringer Ingelheim | N-020884 DISCN | 1999-11-22 | 1 products, RLD |
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Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PERSANTINE | Boehringer Ingelheim | N-012836 DISCN | 1986-12-22 | 3 products, RLD |
| IV PERSANTINE | Boehringer Ingelheim | N-019817 DISCN | 1990-12-13 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aggrenox | New Drug Application | 2016-08-06 |
| aspirin and dipyridamole | ANDA | 2023-12-26 |
| aspirin and dipyridamole extended release | ANDA | 2019-01-18 |
| aspirin and extended - release dipyridamole capsules, 25 mg / 200 mg | ANDA | 2024-10-23 |
| aspirin and extended-release dipyridamole | ANDA | 2024-01-09 |
| aspirin-dipyridamole | ANDA | 2023-05-15 |
| asprin and extended-release dipyridamole | ANDA | 2021-05-31 |
| dipyridamole | ANDA | 2024-10-14 |
| dipyridamole dipyridamole | ANDA | 2018-12-14 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
| J1245 | Injection, dipyridamole, per 10 mg |
Clinical
Clinical Trials
106 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 1 | 1 | 2 | 5 | 11 | 20 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 2 | 3 | 4 | 8 | 17 |
| Healthy volunteers/patients | — | — | — | 14 | 1 | — | 1 | — | 16 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 5 | 2 | 4 | 12 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | 2 | 2 | 6 | 12 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | — | 5 | 5 | 11 |
| Coronary disease | D003327 | — | — | — | 1 | 3 | 1 | 4 | 9 |
| Thrombosis | D013927 | — | — | — | — | — | 3 | 5 | 8 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | 3 | 5 | 8 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 2 | 2 | 2 | 7 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | — | 3 | 1 | — | — | 4 |
| Patent foramen ovale | D054092 | HP_0001655 | Q21.12 | — | — | 1 | — | 1 | 2 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 1 | — | — | 1 |
| Aneurysm | D000783 | HP_0002617 | I72.9 | — | — | 1 | — | — | 1 |
| Heart aneurysm | D006322 | EFO_1000959 | I25.3 | — | — | 1 | — | — | 1 |
| Aortic dissection | D000784 | — | I71.0 | — | — | 1 | — | — | 1 |
| Internal carotid artery dissection | D020215 | — | — | — | — | 1 | — | — | 1 |
| Vertebral artery dissection | D020217 | — | I77.74 | — | — | 1 | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | — | — | 4 | 5 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 4 | — | — | 1 | 5 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 4 | — | — | 1 | 5 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | 1 | — | — | 3 | 4 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 1 | — | — | 3 | 4 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | 1 | — | — | 2 | 3 |
| Carotid stenosis | D016893 | — | — | — | 1 | — | — | 1 | 2 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | 1 | 1 | — | — | 1 | 2 |
| Purpura | D011693 | HP_0000979 | D69.2 | 1 | 1 | — | — | 1 | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Coronary angiography | D017023 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary embolism | D011655 | HP_0002204 | I26 | — | — | — | — | 4 | 4 |
| Embolism | D004617 | — | — | — | — | — | — | 4 | 4 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Myocardial perfusion imaging | D055414 | — | — | — | — | — | — | 2 | 2 |
| Cerebral infarction | D002544 | — | I63 | — | — | — | — | 2 | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | — | — | — | 1 | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | — | 1 | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
Show 27 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dipyridamole |
| INN | dipyridamole |
| Description | Dipyridamole is a pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. It has a role as an adenosine phosphodiesterase inhibitor, an EC 3.5.4.4 (adenosine deaminase) inhibitor, a platelet aggregation inhibitor and a vasodilator agent. It is a member of piperidines, a pyrimidopyrimidine, a tertiary amino compound and a tetrol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 58-32-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL932 |
| ChEBI ID | 4653 |
| PubChem CID | 3108 |
| DrugBank | DB00975 |
| UNII ID | 64ALC7F90C (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
PDE7B
PDE7B
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
PDE7B
Gene synonyms
NCBI Gene ID
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Protein synonyms
high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase, rolipram-insensitive phosphodiesterase type 7
Uniprot ID
Mouse ortholog
Pde7b (29863)
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Q9QXQ1)
Variants
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Financial
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Estimated US medical usage
Dipyridamole
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Aspirin
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Dipyridamole
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Trends
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Safety
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Adverse Events
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3,719 adverse events reported
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