Dipyridamole
Dipyridamole (dipyridamole) is a small molecule pharmaceutical. Dipyridamole was first approved as Persantine on 1986-12-22. The pharmaceutical is active against equilibrative nucleoside transporter 1. In addition, it is known to target high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, equilibrative nucleoside transporter 4, 3',5'-cyclic-AMP phosphodiesterase 7B, and high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Dipyridamole (discontinued: Dipyridamole, Persantine)
CombinationsAspirin dipyridamole (discontinued: Aggrenox, Aspirin dipyridamole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AGGRENOX | Boehringer Ingelheim | N-020884 DISCN | 1999-11-22 | 1 products, RLD |
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Dipyridamole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PERSANTINE | Boehringer Ingelheim | N-012836 DISCN | 1986-12-22 | 3 products, RLD |
| IV PERSANTINE | Boehringer Ingelheim | N-019817 DISCN | 1990-12-13 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aggrenox | New Drug Application | 2016-08-06 |
| aspirin and dipyridamole | ANDA | 2023-12-26 |
| aspirin and dipyridamole extended release | ANDA | 2019-01-18 |
| aspirin and extended - release dipyridamole capsules, 25 mg / 200 mg | ANDA | 2025-01-14 |
| aspirin and extended-release dipyridamole | ANDA | 2025-04-23 |
| aspirin-dipyridamole | ANDA | 2023-05-15 |
| asprin and extended-release dipyridamole | ANDA | 2021-05-31 |
| dipyridamole | ANDA | 2025-01-08 |
| dipyridamole dipyridamole | ANDA | 2018-12-14 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
| J1245 | Injection, dipyridamole, per 10 mg |
Clinical
Clinical Trials
110 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 14 | — | — | 1 | — | 15 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | 2 | — | 4 |
| Ischemic stroke | D000083242 | — | — | — | — | — | 1 | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 1 | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | 1 | — | 1 |
| Arteriosclerosis | D001161 | EFO_0009086 | I70 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | — | 1 | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dipyridamole |
| INN | dipyridamole |
| Description | Dipyridamole is a pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. It has a role as an adenosine phosphodiesterase inhibitor, an EC 3.5.4.4 (adenosine deaminase) inhibitor, a platelet aggregation inhibitor and a vasodilator agent. It is a member of piperidines, a pyrimidopyrimidine, a tertiary amino compound and a tetrol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 58-32-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL932 |
| ChEBI ID | 4653 |
| PubChem CID | 3108 |
| DrugBank | DB00975 |
| UNII ID | 64ALC7F90C (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE7B
PDE7B
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
PDE7B
Gene synonyms
NCBI Gene ID
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Protein synonyms
high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase, rolipram-insensitive phosphodiesterase type 7
Uniprot ID
Mouse ortholog
Pde7b (29863)
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Q9QXQ1)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Dipyridamole
+
Aspirin
Total medical expenditures per year (USD, in millions)
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Dipyridamole
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Trends
PubMed Central
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Additional graphs summarizing 18,309 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,807 adverse events reported
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