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Drug ReportsDipivefrin
Dipivefrin
Akpro, Propine (dipivefrin) is a small molecule pharmaceutical. Dipivefrin was first approved as Propine on 1982-01-01. It is used to treat open-angle glaucoma in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dipivefrin hydrochloride
Tradename
Company
Number
Date
Products
PROPINEAllerganN-018239 DISCN1982-01-01
1 products
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
S01: Ophthalmologicals
S01E: Antiglaucoma preparations and miotics
S01EA: Sympathomimetics in glaucoma therapy
S01EA02: Dipivefrine
HCPCS
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Clinical
Clinical Trials
223 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I1011
Ocular hypertensionD009798EFO_1001069H40.011
GlaucomaD005901EFO_0000516H4011
Open-angle glaucomaD005902EFO_0004190H40.111
CataractD002386EFO_0001059H26.911
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDipivefrin
INNdipivefrine
Description
Dipivefrin is the dipivalate ester of (+-)-epinephrine (racepinephrine). A pro-drug of epinephrine, the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. It has a role as a prodrug, an adrenergic agonist, a sympathomimetic agent, an antiglaucoma drug and an ophthalmology drug. It is a member of ethanolamines and a pivalate ester. It is functionally related to an adrenaline. It is a conjugate base of a dipivefrin(1+).
Classification
Small molecule
Drug class
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Structure (InChI/SMILES or Protein Sequence)
CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1
Identifiers
PDB
CAS-ID52365-63-6
RxCUI
ChEMBL IDCHEMBL1201262
ChEBI ID4646
PubChem CID3105
DrugBankDB00449
UNII ID8Q1PVL543G (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
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Estimated US medical usage
Dipivefrin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 284 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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19 adverse events reported
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