Dipivefrin
Akpro, Propine (dipivefrin) is a small molecule pharmaceutical. Dipivefrin was first approved as Propine on 1982-01-01. It is used to treat open-angle glaucoma in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
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Indications
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| open-angle glaucoma | EFO_0004190 | D005902 | H40.1 |
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Clinical
Clinical Trials
224 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | — | — | 1 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | — | — | 1 | — | — | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | 1 | — | — | 1 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | 1 | — | — | 1 |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | 1 | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dipivefrin |
| INN | dipivefrine |
| Description | Dipivefrin is the dipivalate ester of (+-)-epinephrine (racepinephrine). A pro-drug of epinephrine, the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. It has a role as a prodrug, an adrenergic agonist, a sympathomimetic agent, an antiglaucoma drug and an ophthalmology drug. It is a member of ethanolamines and a pivalate ester. It is functionally related to an adrenaline. It is a conjugate base of a dipivefrin(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 52365-63-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201262 |
| ChEBI ID | 4646 |
| PubChem CID | 3105 |
| DrugBank | DB00449 |
| UNII ID | 8Q1PVL543G (ChemIDplus, GSRS) |
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Dipivefrin
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Safety
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19 adverse events reported
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