Dipivefrin - PharmaKB

Dipivefrin

Akpro, Propine (dipivefrin) is a small molecule pharmaceutical. Dipivefrin was first approved as Propine on 1982-01-01. It is used to treat open-angle glaucoma in the USA.

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Therapeutic Areas

Therapeutic Area	MeSH
eye diseases	D005128

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Drug Products

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New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Dipivefrin hydrochloride

Tradename	Company	Number	Date	Products
PROPINE	Allergan	N-018239 DISCN	1982-01-01	1 products

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Indications

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EMA

Indication	Ontology	MeSH	ICD-10
open-angle glaucoma	EFO_0004190	D005902	H40.1

Agency Specific

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Patent Expiration

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ATC Codes

S: Sensory organ drugs

— S01: Ophthalmologicals

— S01E: Antiglaucoma preparations and miotics

— S01EA: Sympathomimetics in glaucoma therapy

— S01EA02: Dipivefrine

HCPCS

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Clinical

Clinical Trials

221 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Cataract	D002386	EFO_0001059	H26.9	—	—	3	8	76	87
Myopia	D009216	EFO_0003927	H52.1	—	1	1	3	18	22
Astigmatism	D001251	EFO_0004222	H52.2	—	—	—	3	18	21
Glaucoma	D005901	EFO_0000516	H40	1	—	5	2	6	14
Ocular hypertension	D009798	EFO_1001069	H40.0	—	—	5	2	1	8
Labor pain	D048949	—	—	—	—	1	5	2	8
Hypertension	D006973	EFO_0000537	I10	—	—	5	2	—	7
Analgesia	D000698	—	—	—	—	1	2	4	7
Dry eye syndromes	D015352	—	H04.12	2	2	—	3	—	6
Retinal diseases	D012164	—	H35.9	—	—	—	2	3	5

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Otitis	D010031	—	—	1	3	4	—	—	7
Open-angle glaucoma	D005902	EFO_0004190	H40.1	—	—	4	—	2	6
Otitis externa	D010032	EFO_0009560	H60	1	3	3	—	—	6
Keratoconus	D007640	EFO_0004223	H18.6	—	—	1	—	5	6
Bacterial conjunctivitis	D003234	EFO_1000829	H10.0	—	1	2	—	—	3
Conjunctivitis	D003231	—	H10	—	1	2	—	—	3
Exfoliation syndrome	D017889	EFO_0004235	—	—	—	1	—	2	3
Uveitis	D014605	EFO_1001231	H20.9	—	—	1	—	1	2
Anterior uveitis	D014606	EFO_1000811	—	—	—	1	—	—	1
Iridocyclitis	D015863	—	H20	—	—	1	—	—	1

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Eye diseases	D005128	EFO_0003966	H44	—	1	—	—	3	4
Ear diseases	D004427	EFO_1001455	H93.9	1	3	—	—	—	3
Otorhinolaryngologic diseases	D010038	—	—	1	3	—	—	—	3
Infratentorial neoplasms	D015192	—	C71.7	—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Autonomic nervous system diseases	D001342	EFO_0009532	G90	1	—	—	—	—	1
Hypotension	D007022	EFO_0005251	I95	1	—	—	—	—	1
Orthostatic hypotension	D007024	—	I95.1	1	—	—	—	—	1
Nervous system diseases	D009422	—	G00-G99	1	—	—	—	—	1
Primary dysautonomias	D054969	—	—	1	—	—	—	—	1
Orthostatic intolerance	D054971	—	—	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Presbyopia	D011305	—	H52.4	—	—	—	—	13	13
Refractive errors	D012030	HP_0000483	H52.7	—	—	—	—	9	9
Intraocular lenses	D007910	—	—	—	—	—	—	7	7
Aphakia	D001035	—	H27.0	—	—	—	—	6	6
Cataract extraction	D002387	—	—	—	—	—	—	5	5
Agnosia	D000377	EFO_0007136	F88	—	—	—	—	4	4
Retinal perforations	D012167	EFO_1001028	—	—	—	—	—	4	4
Epiretinal membrane	D019773	—	—	—	—	—	—	4	4
Anesthesia	D000758	—	—	—	—	—	—	3	3
Pain	D010146	EFO_0003843	R52	—	—	—	—	3	3

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Dipivefrin
INN	dipivefrine
Description	Dipivefrin is the dipivalate ester of (+-)-epinephrine (racepinephrine). A pro-drug of epinephrine, the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. It has a role as a prodrug, an adrenergic agonist, a sympathomimetic agent, an antiglaucoma drug and an ophthalmology drug. It is a member of ethanolamines and a pivalate ester. It is functionally related to an adrenaline. It is a conjugate base of a dipivefrin(1+).
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1