Diphenidol
Vontrol (diphenidol) is a small molecule pharmaceutical. Diphenidol was first approved as Vontrol on 1982-01-01. It is used to treat nausea, vertigo, and vomiting in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
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FDA
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Brand Name | Status | Last Update |
|---|---|---|
| antiseptic skin cleanser | New Drug Application | 2024-02-13 |
| rugby petrolatum hydrating | C200263 | 2024-02-12 |
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Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vertigo | D014717 | — | H81.39 | — | — | — | 1 | — | 1 |
| Meniere disease | D008575 | EFO_0006862 | H81.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Diphenidol |
| INN | difenidol |
| Description | Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OC(CCCN1CCCCC1)(c1ccccc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 972-02-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL936 |
| ChEBI ID | 4638 |
| PubChem CID | 9175 |
| DrugBank | DB01231 |
| UNII ID | NQO8R319LY (ChemIDplus, GSRS) |
Target
Agency Approved
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CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
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35 adverse events reported
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