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Drug ReportsDiphenidol
Diphenidol
Vontrol (diphenidol) is a small molecule pharmaceutical. Diphenidol was first approved as Vontrol on 1982-01-01. It is used to treat nausea, vertigo, and vomiting in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diphenidol hydrochloride
Tradename
Company
Number
Date
Products
VONTROLGSKN-016033 DISCN1982-01-01
1 products
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FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VertigoD014717H81.3911
Meniere diseaseD008575EFO_0006862H81.011
Ganglion cystsD045888M67.411
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDiphenidol
INNdifenidol
Description
Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada.
Classification
Small molecule
Drug class
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Structure (InChI/SMILES or Protein Sequence)
OC(CCCN1CCCCC1)(c1ccccc1)c1ccccc1
Identifiers
PDB
CAS-ID972-02-1
RxCUI
ChEMBL IDCHEMBL936
ChEBI ID4638
PubChem CID9175
DrugBankDB01231
UNII IDNQO8R319LY (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
Organism
Homo sapiens
Gene name
CHRM4
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M4
Protein synonyms
acetylcholine receptor, muscarinic 4
Uniprot ID
Mouse ortholog
Chrm4 (12672)
muscarinic acetylcholine receptor M4 (Q64056)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 269 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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43 adverse events reported
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