Dinaciclib
Dinaciclib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cyclin-dependent kinase 9, cyclin-dependent kinase 1, cyclin-dependent kinase 2, and cyclin-dependent kinase 5.
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Commercial
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 2 | 1 | — | — | 5 |
| Lymphoid leukemia | D007945 | — | C91 | 2 | 2 | 1 | — | — | 5 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 1 | 1 | — | — | 4 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dinaciclib |
| INN | dinaciclib |
| Description | 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol is a pyrazolopyrimidine. |
| Classification | Small molecule |
| Drug class | cyclin dependent kinase inhibitors (formerly-cidib) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 |
Identifiers
| PDB | — |
| CAS-ID | 779353-01-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103840 |
| ChEBI ID | — |
| PubChem CID | 46926350 |
| DrugBank | DB12021 |
| UNII ID | 4V8ECV0NBQ (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CDK9
CDK9
CDK1
CDK1
CDK2
CDK2
CDK5
CDK5
Organism
Homo sapiens
Gene name
CDK9
Gene synonyms
CDC2L4, TAK
NCBI Gene ID
Protein name
cyclin-dependent kinase 9
Protein synonyms
C-2K, CDC2-related kinase, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, serine/threonine protein kinase PITALRE, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit
Uniprot ID
Mouse ortholog
Cdk9 (107951)
cyclin-dependent kinase 9 (Q99J95)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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23 adverse events reported
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