Dimethindene
Dimethindene is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histamine H1 receptor, muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M5.
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Commercial
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
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Agency Specific
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ATC Codes
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AA: Antihistamines for topical use
— D04AA13: Dimetindene
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB03: Dimetindene
HCPCS
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Nasal obstruction | D015508 | HP_0001742 | — | — | — | 1 | — | — | 1 |
| Rhinorrhea | D000086722 | — | — | — | — | 1 | — | — | 1 |
| Sneezing | D012912 | EFO_0004290 | R06.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | D001794 | EFO_0004325 | — | 1 | 1 | — | — | — | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | 1 | 1 | — | — | — | 1 |
| Heart rate | D006339 | EFO_0004326 | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | — | 1 | 1 |
| Eczema | D004485 | HP_0000964 | L30.9 | — | — | — | — | 1 | 1 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dimethindene |
| INN | dimetindene |
| Description | Dimetindene is an indene. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 |
Identifiers
| PDB | — |
| CAS-ID | 5636-83-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL22108 |
| ChEBI ID | — |
| PubChem CID | 21855 |
| DrugBank | DB08801 |
| UNII ID | 661FH77Z3P (ChemIDplus, GSRS) |
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Trends
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Safety
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216 adverse events reported
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