Dimethindene
Dimethindene is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histamine H1 receptor, muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M5.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
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ATC Codes
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AA: Antihistamines for topical use
— D04AA13: Dimetindene
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB03: Dimetindene
HCPCS
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anaphylaxis | D000707 | — | T78.2 | — | — | — | 1 | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | 1 | — | 1 |
| Food hypersensitivity | D005512 | EFO_1001890 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Nasal obstruction | D015508 | — | — | — | — | 1 | — | — | 1 |
| Rhinorrhea | D000086722 | — | — | — | — | 1 | — | — | 1 |
| Sneezing | D012912 | EFO_0004290 | R06.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | D001794 | EFO_0004325 | — | 1 | 1 | — | — | — | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | 1 | 1 | — | — | — | 1 |
| Heart rate | D006339 | EFO_0004326 | — | 1 | 1 | — | — | — | 1 |
| Fatigue | D005221 | — | R53.83 | — | 1 | — | — | — | 1 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | 1 | — | — | — | 1 |
| Hemophilia b | D002836 | — | D67 | — | 1 | — | — | — | 1 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | — | 1 | 1 |
| Eczema | D004485 | — | L30.9 | — | — | — | — | 1 | 1 |
| Dermatitis | D003872 | — | L30.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dimethindene |
| INN | dimetindene |
| Description | Dimetindene is an indene. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 |
Identifiers
| PDB | — |
| CAS-ID | 5636-83-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL22108 |
| ChEBI ID | — |
| PubChem CID | 21855 |
| DrugBank | DB08801 |
| UNII ID | 661FH77Z3P (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Additional graphs summarizing 422 documents
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Safety
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Adverse Events
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269 adverse events reported
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