Dihydroergotamine
Dihydroergotamine, Embolex, Migranal, Trudhesa (dihydroergotamine) is a small molecule pharmaceutical. Dihydroergotamine was first approved as D.h.e. 45 on 1982-01-01. It is used to treat cluster headache, migraine disorders, orthostatic hypotension, postpartum hemorrhage, and xerostomia in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 6.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Atzumi, Brekiya, Dihydroergotamine, Migranal, Trudhesa (discontinued: D.h.e. 45, Dihydroergotamine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Dihydroergotamine mesylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BREKIYA (AUTOINJECTOR) | Amneal Pharmaceuticals | N-215400 RX | 2025-05-14 | 1 products, RLD, RS |
| MIGRANAL | Bausch Health Companies | N-020148 RX | 1997-12-08 | 1 products, RLD, RS |
| TRUDHESA | Impel Pharmaceuticals | N-213436 RX | 2021-09-02 | 1 products, RLD, RS |
| ATZUMI | Satsuma Pharmaceuticals | N-217901 RX | 2025-04-30 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atzumi | New Drug Application | 2025-05-08 |
| balance plus cream | unapproved drug other | 2025-06-01 |
| brekiya | New Drug Application | 2025-10-04 |
| dihydroergotamine mesylate | ANDA | 2026-01-07 |
| dihydroergotamine mesylate nasal | ANDA | 2025-12-29 |
| dromelate | ANDA | 2022-02-23 |
| trudhesa | New Drug Application | 2025-01-17 |
Indications
FDA
EMA
Show 12 more
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
DIHYDROERGOTAMINE MESYLATE, TRUDHESA, IMPEL PHARMS | |||
| 2024-09-02 | NP | ||
HCPCS
Code | Description |
|---|---|
| J1110 | Injection, dihydroergotamine mesylate, per 1 mg |
Clinical
Clinical Trials
74 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 4 | 1 | 7 | 1 | 1 | 14 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma | D018281 | — | C22.1 | — | 3 | 7 | — | 3 | 11 |
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | 2 | — | 3 | — | — | 5 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | 2 | — | 3 | — | — | 5 |
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | — | 3 | 2 | — | 1 | 5 |
| Headache | D006261 | — | R51 | 2 | — | 2 | — | — | 4 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 2 | 1 | 1 | — | — | 4 |
| Esophageal neoplasms | D004938 | — | C15 | — | 2 | 1 | — | 1 | 4 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | 2 | — | — | 3 |
| Pathologic constriction | D003251 | — | — | 1 | 2 | 1 | — | 1 | 3 |
| Glioma | D005910 | EFO_0000520 | — | 1 | 1 | 1 | — | — | 3 |
Show 14 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 5 | 3 | — | — | 4 | 11 |
| Lung neoplasms | D008175 | — | C34.90 | 3 | 2 | — | — | 5 | 9 |
| Healthy volunteers/patients | — | — | — | 6 | 1 | — | — | — | 6 |
| Malignant mesothelioma | D000086002 | — | — | 1 | 3 | — | — | 1 | 5 |
| Head and neck neoplasms | D006258 | — | — | 1 | 2 | — | — | 1 | 4 |
| Neoplasms | D009369 | — | C80 | 2 | 2 | — | — | — | 3 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 2 | — | — | 1 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | — | 1 | 2 |
| Mouth neoplasms | D009062 | EFO_0003868 | C06.9 | — | 1 | — | — | 1 | 2 |
Show 16 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pleural diseases | D010995 | — | — | 2 | — | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | 1 | 2 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | — | 1 |
| Acinar cell carcinoma | D018267 | — | — | 1 | — | — | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
| Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
| Chordoma | D002817 | EFO_0000334 | — | 1 | — | — | — | — | 1 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 1 | — | — | — | — | 1 |
| Ependymoma | D004806 | — | — | 1 | — | — | — | — | 1 |
| Pituitary neoplasms | D010911 | — | — | 1 | — | — | — | — | 1 |
Show 7 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Squamous cell neoplasms | D018307 | — | — | — | — | — | — | 1 | 1 |
| Adenocarcinoma of lung | D000077192 | — | — | — | — | — | — | 1 | 1 |
| Cigarette smoking | D000073865 | — | — | — | — | — | — | 1 | 1 |
| Ureteral obstruction | D014517 | — | — | — | — | — | — | 1 | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | — | — | 1 | 1 |
| Obstructive jaundice | D041781 | EFO_1001068 | — | — | — | — | — | 1 | 1 |
| Jaundice | D007565 | — | R17 | — | — | — | — | 1 | 1 |
| Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Dihydroergotamine |
| INN | dihydroergotamine |
| Description | Dihydroergotamine is ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension. It has a role as a serotonergic agonist, a non-narcotic analgesic, a vasoconstrictor agent, a dopamine agonist and a sympatholytic agent. It is an ergot alkaloid and a semisynthetic derivative. |
| Classification | Small molecule |
| Drug class | ergot alkaloid deriviatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 511-12-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1732 |
| ChEBI ID | 4562 |
| PubChem CID | 10531 |
| DrugBank | DB00320 |
| UNII ID | 436O5HM03C (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Dihydroergotamine
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 16,323 documents
View more details
Safety
Black-box Warning
Black-box warning for: Atzumi, Brekiya, Dihydroergotamine mesylate, Dihydroergotamine mesylate nasal, Dromelate, Trudhesa
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
3,402 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use