Dihydrocodeine
Dhc, Synalgos-dc, Synalgos-dc-a, Trezix (dihydrocodeine) is a small molecule pharmaceutical. Dihydrocodeine was first approved as Synalgos-dc on 1983-09-06. It is used to treat cough and pain in the USA.
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Commercial
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Drug Products
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
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Caffeine
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Dihydrocodeine bitartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYNALGOS-DC | Sun Pharmaceutical Industries | N-011483 DISCN | 1983-09-06 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acetaminophen, caffeine and dihydrocodeine bitartrate | 2006-10-06 | |
| acetaminophen, caffeine, dihydrocodeine bitartrate | ANDA | 2021-01-30 |
| dihydrocodeine bitartrate, acetaminophen and caffeine | ANDA | 2009-11-24 |
| trezix | ANDA | 2022-05-02 |
Indications
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Agency Specific
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Patent Expiration
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ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AA: Natural opium alkaloid analgesics
— N02AA08: Dihydrocodeine
— N02AA58: Dihydrocodeine, combinations
— N02AJ: Opioids in combination with non-opioid analgesics
— N02AJ01: Dihydrocodeine and paracetamol
— N02AJ02: Dihydrocodeine and acetylsalicylic acid
— N02AJ03: Dihydrocodeine and other non-opioid analgesics
HCPCS
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 2 | — | 2 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
| Nociceptive pain | D059226 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dihydrocodeine |
| INN | dihydrocodeine |
| Description | Dihydrocodeine is a morphinane alkaloid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc2c3c1O[C@H]1[C@@H](O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314 |
Identifiers
| PDB | — |
| CAS-ID | 125-28-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1595 |
| ChEBI ID | — |
| PubChem CID | 5284543 |
| DrugBank | DB01551 |
| UNII ID | N9I9HDB855 (ChemIDplus, GSRS) |
Target
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Financial
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Estimated US medical usage
Dihydrocodeine
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Phenylephrine
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Brompheniramine
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Dihydrocodeine
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Phenylephrine
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Chlorpheniramine
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Trends
PubMed Central
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Additional graphs summarizing 1,766 documents
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Safety
Black-box Warning
Black-box warning for: Acetaminophen, caffeine, dihydrocodeine bitartrate, Trezix
Adverse Events
Top Adverse Reactions
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3,293 adverse events reported
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