Digitalis
Digitalis is an unknown pharmaceutical. It is currently being investigated in clinical studies.
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5Y
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01A: Cardiac glycosides
— C01AA: Digitalis glycosides
— C01AA03: Digitalis leaves
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AB: Antidotes
— V03AB24: Digitalis antitoxin
HCPCS
No data
Clinical
Clinical Trials
231 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 79 | — | — | 1 | — | 80 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | — | 5 | 4 | 9 | 19 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | 3 | 8 | 4 | 16 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | 1 | — | 1 | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | — | 1 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | 1 | — | 1 |
| Presbyopia | D011305 | — | H52.4 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 3 | — | 1 | 4 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | 3 | — | 1 | 4 |
| Supraventricular tachycardia | D013617 | — | I47.1 | — | — | 2 | — | 1 | 3 |
| Sarcoma | D012509 | — | — | — | 2 | 1 | — | — | 3 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | — | 2 | — | — | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 2 | — | — | 2 |
| Leiomyosarcoma | D007890 | — | — | — | — | 1 | — | — | 1 |
| Alveolar soft part sarcoma | D018234 | — | — | — | — | 1 | — | — | 1 |
| Synovial sarcoma | D013584 | — | — | — | — | 1 | — | — | 1 |
| Sinus arrhythmia | D001146 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 9 | 1 | — | — | — | 10 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 2 | — | — | 1 | 5 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 4 | 1 | — | — | — | 5 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 3 | 1 | — | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 1 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 2 | — | — | — | 3 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 2 | — | — | — | 3 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | — | — | — | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | — | — | 1 | 2 |
Show 25 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 11 | — | — | — | — | 11 |
| Drug interactions | D004347 | — | — | 9 | — | — | — | — | 9 |
| Overweight | D050177 | — | E66.3 | 8 | — | — | — | — | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 7 | — | — | — | — | 7 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 4 | — | — | — | — | 4 |
| Pharmacokinetics | D010599 | — | — | 4 | — | — | — | — | 4 |
| Melanoma | D008545 | — | — | 3 | — | — | — | — | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | — | 3 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 2 | — | — | — | — | 2 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 2 | — | — | — | — | 2 |
Show 35 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Induced abortion | D000028 | — | — | — | — | — | — | 2 | 2 |
| Congenital heart defects | D006330 | — | Q24.9 | — | — | — | — | 1 | 1 |
| Exercise test | D005080 | EFO_0004328 | — | — | — | — | — | 1 | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Mammaplasty | D016462 | — | — | — | — | — | — | 1 | 1 |
| Breast diseases | D001941 | — | N60-N65 | — | — | — | — | 1 | 1 |
| Fibrocystic breast disease | D005348 | — | N60 | — | — | — | — | 1 | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | — | — | — | 1 | 1 |
| Papillary thyroid cancer | D000077273 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Digitalis |
| INN | _ |
| Description | Digitoxin is a cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is functionally related to a digitoxigenin. It is a conjugate acid of a digitoxin(1-). |
| Classification | Unknown |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109172 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | UD4O8TY7RW (ChemIDplus, GSRS) |
Target
No data
Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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63 adverse events reported
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