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AboutPricing
Drug ReportsDiflorasone
Diflorasone diacetate
Diflorasone (diflorasone diacetate) is a small molecule pharmaceutical. Diflorasone diacetate was first approved as Florone on 1982-01-01. It is used to treat facial dermatoses, foot dermatoses, hand dermatoses, inflammation, and leg dermatoses amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Diflorasone (discontinued: Diflorasone, Florone, Psorcon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diflorasone diacetate
Tradename
Company
Number
Date
Products
FLORONEPfizerN-017741 DISCN1982-01-01
1 products
FLORONE EPfizerN-019259 DISCN1985-08-28
1 products
PSORCONPfizerN-019260 DISCN1985-08-28
1 products, RLD
PSORCON EPfizerN-017994 DISCN1982-01-01
1 products
PSORCONTaro PharmaceuticalN-020205 DISCN1992-11-20
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
apexicon eANDA2022-10-20
diflorasone diacetateANDA2024-06-14
psorconANDA2018-07-05
psorcon e2007-08-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pruritusHP_0000989D011537L29
inflammationMP_0001845D007249—
facial dermatoses—D005148—
foot dermatoses—D005533—
hand dermatoses—D006229—
scalp dermatoses—D012536—
leg dermatoses—D007868—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC10: Diflorasone
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameDiflorasone diacetate
INNdiflorasone
Description
Diflorasone diacetate is the 17,21-diacetate derivative of diflorasone. It is used topically for its anti-inflammatory and antipruritic properties in the treatment of various skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is an 11beta-hydroxy steroid, a glucocorticoid, a 20-oxo steroid, a fluorinated steroid, an acetate ester and a 3-oxo-Delta(1),Delta(4)-steroid. It is functionally related to a diflorasone and an acetic acid. It derives from a hydride of a pregnane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(=O)OCC(=O)[C@@]1(OC(C)=O)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
Identifiers
PDB—
CAS-ID33564-31-7
RxCUI—
ChEMBL IDCHEMBL1200545
ChEBI ID31483
PubChem CID71414
DrugBankDB00223
UNII IDT2DHJ9645W (ChemIDplus, GSRS)
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
2908
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Q6N0A4
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Diflorasone diacetate
+
Diflorasone
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 124 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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33 adverse events reported
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