Difamilast
Difamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 3',5'-cyclic-AMP phosphodiesterase 4D.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
No data
Clinical
Clinical Trials
14 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 2 | 4 | 8 | — | — | 14 |
| Dermatitis | D003872 | — | L30.9 | 2 | 4 | 8 | — | — | 14 |
| Eczema | D004485 | — | L30.9 | 1 | 4 | 8 | — | — | 13 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Difamilast |
| INN | difamilast |
| Description | Difamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D. |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines): type IV phosphodiesterase |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1ccccc1C(=O)NCc1coc(-c2ccc(OC(F)F)c(OC(C)C)c2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 937782-05-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989968 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | T3U32GLJ0F (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE4D
PDE4D
Organism
Homo sapiens
Gene name
PDE4D
Gene synonyms
DPDE3
NCBI Gene ID
Protein name
3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Protein synonyms
cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase PDE4D6, DPDE3, PDE43, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila), testicular tissue protein Li 136
Uniprot ID
Mouse ortholog
Pde4d (238871)
3',5'-cyclic-AMP phosphodiesterase 4D (Q8CG05)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 49 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use