Difamilast
Difamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 3',5'-cyclic-AMP phosphodiesterase 4D.
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FDA approval date
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Commercial
No data
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 2 | 4 | 10 | — | — | 16 |
| Dermatitis | D003872 | — | L30.9 | 2 | 4 | 7 | — | — | 13 |
| Eczema | D004485 | — | L30.9 | 1 | 4 | 7 | — | — | 12 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Difamilast |
| INN | difamilast |
| Description | Difamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D. |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines): type IV phosphodiesterase |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1ccccc1C(=O)NCc1coc(-c2ccc(OC(F)F)c(OC(C)C)c2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 937782-05-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989968 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | T3U32GLJ0F (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE4D
PDE4D
Organism
Homo sapiens
Gene name
PDE4D
Gene synonyms
DPDE3
NCBI Gene ID
Protein name
3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Protein synonyms
cAMP-specific phosphodiesterase 4D, cAMP-specific phosphodiesterase PDE4D6, DPDE3, PDE43, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila), testicular tissue protein Li 136
Uniprot ID
Mouse ortholog
Pde4d (238871)
3',5'-cyclic-AMP phosphodiesterase 4D (Q8CG05)
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 71 documents
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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