Diethylpropion
Diethylpropion (diethylpropion) is a small molecule pharmaceutical. Diethylpropion was first approved as Tepanil on 1982-01-01. It is used to treat obesity in the USA.
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Commercial
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Trade Name
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Diethylpropion (discontinued: Diethylpropion, Tenuate, Tenuate dospan, Tepanil, Tepanil ten-tab)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diethylpropion hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TEPANIL | 3M | N-011673 DISCN | 1982-01-01 | 1 products |
| TEPANIL TEN-TAB | 3M | N-017956 DISCN | 1982-01-01 | 1 products |
| TENUATE | Nostrum Laboratories | N-011722 DISCN | 1982-01-01 | 1 products, RLD |
| TENUATE DOSPAN | Nostrum Laboratories | N-012546 DISCN | 1982-01-01 | 1 products, RLD |
| TENUATE | Sanofi | N-017668 DISCN | 1982-01-01 | 1 products |
| TENUATE | Sanofi | N-017669 DISCN | 1982-01-01 | 1 products |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| diethylpropion | ANDA | 2024-10-10 |
| diethylpropion hcl | New Drug Application | 2012-03-27 |
| diethylpropion hcl controlled-release | ANDA | 2015-03-26 |
| diethylpropion hcl controlled-release diethylpropion hcl immediate-release | New Drug Application | 2018-10-09 |
| diethylpropion hydrochloride | ANDA | 2024-10-08 |
| diethylpropion hydrochloride diethylpropion hydrochloride er | ANDA | 2010-04-30 |
| diethylpropion hydrochloride er | ANDA | 2024-10-10 |
| diethylpropion hydrochlorideer | ANDA | 2013-12-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| obesity | EFO_0001073 | D009765 | E66.9 |
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Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | 2 | 3 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | 1 | — | — | — | 1 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 1 | 1 | — | — | — | 1 |
| Hyperkinesis | D006948 | HP_0000752 | — | 1 | 1 | — | — | — | 1 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overweight | D050177 | — | E66.3 | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Diethylpropion |
| INN | amfepramone |
| Description | Diethylpropion is an aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity. It has a role as an appetite depressant. It is a tertiary amine and an aromatic ketone. It is functionally related to a propiophenone. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(C)C(=O)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 90-84-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1194666 |
| ChEBI ID | 4530 |
| PubChem CID | 7029 |
| DrugBank | DB00937 |
| UNII ID | Q94YYU22B8 (ChemIDplus, GSRS) |
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Estimated US medical usage
Diethylpropion
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Trends
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Safety
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49 adverse events reported
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