Diethylcarbamazine
Hetrazan (diethylcarbamazine) is a small molecule pharmaceutical. Diethylcarbamazine was first approved as Hetrazan on 1982-01-01. It is used to treat filarial elephantiasis, loiasis, and pulmonary eosinophilia in the USA.
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Diethylcarbamazine citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HETRAZAN | Lederle Laboratories | N-006459 DISCN | 1982-01-01 | 1 products |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| filarial elephantiasis | EFO_0007272 | D004605 | B74.0 |
| loiasis | — | D008118 | B74.3 |
| pulmonary eosinophilia | EFO_0007257 | D011657 | J82.81 |
Agency Specific
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | 1 | 3 | 6 |
| Loiasis | D008118 | — | B74.3 | — | 2 | — | 1 | 1 | 4 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Filariasis | D005368 | — | B74 | 1 | 4 | 2 | — | 9 | 16 |
| Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | 1 | 4 | 3 | — | 7 | 15 |
| Elephantiasis | D004604 | EFO_0004711 | — | 1 | 4 | 2 | — | 7 | 14 |
| Scabies | D012532 | — | B86 | — | — | 2 | — | 1 | 3 |
| Yaws | D015001 | EFO_0007548 | A66 | — | 1 | 1 | — | — | 2 |
| Strongyloidiasis | D013322 | EFO_0007501 | B78 | — | — | 2 | — | — | 2 |
| Trachoma | D014141 | — | A71 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Onchocerciasis | D009855 | EFO_0007402 | B73 | — | 2 | — | — | 3 | 5 |
| Wuchereria bancrofti | D014958 | — | — | 1 | 1 | — | — | — | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | — | 1 |
| Eosinophilia | D004802 | — | D72.1 | — | 1 | — | — | — | 1 |
| Ocular onchocerciasis | D015827 | EFO_0007398 | B73 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Helminthiasis | D006373 | EFO_1001342 | B65-B83 | — | — | — | — | 2 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 2 | 2 |
| Impetigo | D007169 | EFO_1000714 | L01 | — | — | — | — | 1 | 1 |
| Mansonelliasis | D008368 | EFO_0007357 | B74.4 | — | — | — | — | 1 | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 1 | 1 |
| Neglected diseases | D058069 | — | — | — | — | — | — | 1 | 1 |
| Communicable diseases | D003141 | — | — | — | — | — | — | 1 | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Diethylcarbamazine |
| INN | diethylcarbamazine |
| Description | Diethylcarbamazine is a N-methylpiperazine and a N-carbamoylpiperazine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)C(=O)N1CCN(C)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 90-89-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL684 |
| ChEBI ID | 4527 |
| PubChem CID | 3052 |
| DrugBank | DB00711 |
| UNII ID | V867Q8X3ZD (ChemIDplus, GSRS) |
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Safety
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1,617 adverse events reported
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