Dienestrol
Dv, Estraguard (dienestrol) is a small molecule pharmaceutical. Dienestrol was first approved as Dienestrol on 1982-01-01. It is used to treat atrophic vaginitis and vulvar lichen sclerosus in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dienestrol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIENESTROL | Johnson & Johnson | N-006110 DISCN | 1982-01-01 | 1 products |
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FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| vulvar lichen sclerosus | — | D007724 | N90.4 |
| atrophic vaginitis | EFO_1001271 | D059268 | — |
Agency Specific
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Clinical
Clinical Trials
76 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 2 | — | 2 |
| Congenital microtia | D065817 | — | Q16.0 | — | — | — | 1 | — | 1 |
| Mania | D000087122 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dengue | D003715 | — | A90 | 7 | 6 | 1 | — | — | 14 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 3 | 1 | — | — | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 1 | 1 | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 1 | — | — | 1 |
| Sexually transmitted diseases | D012749 | — | A50-A64 | — | — | 1 | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 1 | 1 | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | 1 | 1 | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 1 | 3 | — | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 3 | — | — | — | 3 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 1 | 2 |
| Transitional cell carcinoma | D002295 | — | — | — | 2 | — | — | — | 2 |
| Local anesthesia | D000772 | — | — | — | 1 | — | — | — | 1 |
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 1 | — | — | — | 1 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 1 | 1 | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | — | 1 | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pathologic constriction | D003251 | — | — | — | — | — | — | 4 | 4 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | — | — | 3 | 3 |
| Burns | D002056 | — | T30.0 | — | — | — | — | 3 | 3 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 3 | 3 |
| Stents | D015607 | — | — | — | — | — | — | 2 | 2 |
| Biliary tract diseases | D001660 | EFO_0009534 | K83.9 | — | — | — | — | 2 | 2 |
| Fluid therapy | D005440 | — | — | — | — | — | — | 2 | 2 |
| Food diet and nutrition | D000066888 | — | — | — | — | — | — | 2 | 2 |
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 2 | 2 |
| Fetal growth retardation | D005317 | EFO_0000495 | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dienestrol |
| INN | dienestrol |
| Description | Dienestrol is an olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively. It has a role as a xenoestrogen. It is a member of phenols and an olefinic compound. |
| Classification | Small molecule |
| Drug class | estrogens |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C/C=C(C(=C/C)/c1ccc(O)cc1)\c1ccc(O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 84-17-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1018 |
| ChEBI ID | — |
| PubChem CID | 667476 |
| DrugBank | DB00890 |
| UNII ID | RRW32X4U1F (ChemIDplus, GSRS) |
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Dienestrol
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Safety
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Adverse Events
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104,539 adverse events reported
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