Dicloxacillin
Dicloxacillin (dicloxacillin) is a small molecule pharmaceutical. Dicloxacillin was first approved as Dynapen on 1982-01-01. It is used to treat bacterial infections, bacterial pneumonia, cellulitis, osteomyelitis, and postoperative complications amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Dicloxacillin (discontinued: Dicloxacillin, Dycill, Dynapen, Pathocil)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| dicloxacillin sodium | ANDA | 2024-10-21 |
Indications
FDA
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | 1 | 1 | 3 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | 1 | 1 | 1 | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | 1 | — | 2 |
| Communicable diseases | D003141 | — | — | — | — | 1 | 1 | — | 2 |
| Endocarditis | D004696 | EFO_0000465 | I33 | — | — | — | 2 | — | 2 |
| Infectious arthritis | D001170 | EFO_1001351 | M00 | — | — | — | 1 | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | 1 | — | 1 |
| Intravenous substance abuse | D015819 | — | — | — | — | — | 1 | — | 1 |
| Bacterial endocarditis | D004697 | EFO_1000830 | — | — | — | — | 1 | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | — | — | 1 | — | — | 1 |
| Gram-positive bacterial infections | D016908 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Rupture | D012421 | — | — | — | — | — | — | 2 | 2 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | — | — | 2 | 2 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Tibial fractures | D013978 | EFO_0003944 | S82.20 | — | — | — | — | 1 | 1 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 1 | 1 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dicloxacillin |
| INN | dicloxacillin |
| Description | Dicloxacillin is a penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group. It has a role as an antibacterial drug. It is a penicillin and a dichlorobenzene. It is a conjugate acid of a dicloxacillin(1-). |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 3116-76-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL893 |
| ChEBI ID | 4511 |
| PubChem CID | 18381 |
| DrugBank | DB00485 |
| UNII ID | COF19H7WBK (ChemIDplus, GSRS) |
Target
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Variants
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Estimated US medical usage
Dicloxacillin
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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409 adverse events reported
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