Diazoxide
Diazoxide, Proglycem (diazoxide) is a small molecule pharmaceutical. Diazoxide was first approved as Hyperstat on 1982-01-01. It is used to treat hypoglycemia and malignant hypertension in the USA. It is known to target ATP-sensitive inward rectifier potassium channel 8 and ATP-sensitive inward rectifier potassium channel 11.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Diazoxide, Proglycem (discontinued: Diazoxide, Hyperstat, Proglycem)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperphagia | — | D006963 | R63.2 |
| hypoglycemia | — | D007003 | E16.2 |
| malignant hypertension | EFO_1001031 | D006974 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02D: Arteriolar smooth muscle, agents acting on
— C02DA: Thiazide derivatives acting on arteriolar smooth muscle
— C02DA01: Diazoxide
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AH: Drugs for treatment of hypoglycemia
— V03AH01: Diazoxide
HCPCS
Code | Description |
|---|---|
| J1730 | Injection, diazoxide, up to 300 mg |
Clinical
Clinical Trials
35 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 3 | — | 2 | 1 | 6 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 3 | — | 1 | — | 5 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | 3 | 1 | 4 |
| Hypoglycemia | D007003 | — | E16.2 | — | 1 | 1 | 3 | — | 4 |
| Glucose metabolism disorders | D044882 | — | — | — | 3 | — | 1 | — | 4 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 4 | 1 | — | — | 6 |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | 3 | 2 | 1 | — | — | 6 |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | 1 | 2 | 4 | — | — | 6 |
| Syndrome | D013577 | — | — | 1 | 1 | 4 | — | — | 5 |
| Hyperinsulinism | D006946 | — | E16.1 | 2 | 1 | 1 | — | — | 4 |
| Pregnancy in diabetics | D011254 | — | O24.91 | — | 1 | 1 | — | — | 1 |
| Newborn infant diseases | D007232 | — | — | — | 1 | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
| Craniopharyngioma | D003397 | — | — | — | — | 1 | — | — | 1 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 2 | 3 | — | — | — | 5 |
| Sexual infantilism | D050035 | — | — | — | 1 | — | — | — | 1 |
| Dyslipidemias | D050171 | — | — | — | 1 | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial stunning | D017682 | — | — | 2 | — | — | — | — | 2 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 1 | — | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | — | 1 | 1 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 1 | 1 |
| Reperfusion injury | D015427 | — | — | — | — | — | — | 1 | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 1 | 1 |
| Fever | D005334 | — | R50.9 | — | — | — | — | 1 | 1 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | — | — | — | 1 | 1 |
| Hyperthermia | D000084462 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Diazoxide |
| INN | diazoxide |
| Description | Diazoxide is a benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. It has a role as an antihypertensive agent, a sodium channel blocker, a vasodilator agent, a K-ATP channel agonist, a beta-adrenergic agonist, a cardiotonic drug, a bronchodilator agent, a sympathomimetic agent and a diuretic. It is a benzothiadiazine, a sulfone and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |
Identifiers
| PDB | — |
| CAS-ID | 364-98-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL181 |
| ChEBI ID | 4495 |
| PubChem CID | 3019 |
| DrugBank | DB01119 |
| UNII ID | O5CB12L4FN (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NAMPT
NAMPT
Organism
Homo sapiens
Gene name
NAMPT
Gene synonyms
PBEF, PBEF1
NCBI Gene ID
Protein name
nicotinamide phosphoribosyltransferase
Protein synonyms
NAmPRTase, Pre-B cell-enhancing factor, Pre-B-cell colony-enhancing factor 1, Visfatin
Uniprot ID
Mouse ortholog
Nampt (59027)
nicotinamide phosphoribosyltransferase (Q9JKM0)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Diazoxide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,843 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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588 adverse events reported
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