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AboutPricing
Drug ReportsDiazepam
Diazepam
Diastat, Diazepam, Libervant, Valium, Valtoco (diazepam) is a small molecule pharmaceutical. Diazepam was first approved as Valium on 1982-01-01. It is used to treat alcohol withdrawal delirium, muscle spasticity, panic disorder, and status epilepticus in the USA. The pharmaceutical is active against gamma-aminobutyric acid receptor subunit alpha-1, gamma-aminobutyric acid receptor subunit alpha-3, and gamma-aminobutyric acid receptor subunit alpha-2. In addition, it is known to target thyrotropin-releasing hormone receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Diastat acudial, Diazepam, Libervant, Valium, Valtoco (discontinued: Diastat acudial, Diazepam, Dizac, Valium, Valrelease)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diazepam
Tradename
Company
Number
Date
Products
LIBERVANTAquestive TherapeuticsN-218623 RX2024-04-26
5 products, RLD, RS
DIASTATBausch Health CompaniesN-020648 RX1997-07-29
1 products, RLD, RS
DIASTAT ACUDIALBausch Health CompaniesN-020648 RX2005-09-15
2 products, RLD, RS
VALTOCONeurelisN-211635 RX2020-01-10
3 products, RLD, RS
VALIUMWaylis TherapeuticsN-013263 RX1982-01-01
3 products, RLD, RS
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Labels
FDA
EMA
Brand Name
Status
Last Update
diazepamANDA2025-03-14
diazepam diazepam intensolANDA2016-07-05
diazepam intensolANDA2022-11-17
gabavale-5unapproved drug other2011-08-01
libervantNew Drug Application2024-11-13
valiumNew Drug Application2025-01-06
valtocoNew Drug Application2024-12-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
muscle spasticity—D009128—
status epilepticusEFO_0008526D013226G41
alcohol withdrawal deliriumEFO_1000800D000430—
panic disorderEFO_0004262D016584F41.0
Agency Specific
FDA
EMA
Expiration
Code
DIAZEPAM, VALTOCO, NEURELIS INC
2027-01-10ODE-279
2023-01-10NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Diazepam, Valtoco, Neurelis Inc
88955462029-03-27DP
112414142029-03-27DP
89274972025-07-21DPU-2727
96429132025-05-11DP
102654022025-05-11DP
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BA: Benzodiazepine derivative anxiolytics
— N05BA01: Diazepam
HCPCS
Code
Description
J3360
Injection, diazepam, up to 5 mg
Clinical
Clinical Trials
191 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.9311——4
SeizuresD012640—G40.41—1——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDiazepam
INNdiazepam
Description
Diazepam is a 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5. It has a role as a xenobiotic, an environmental contaminant, an anxiolytic drug, an anticonvulsant and a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound.
Classification
Small molecule
Drug classantianxiety agents (diazepam type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc21
Identifiers
PDB—
CAS-ID439-14-5
RxCUI—
ChEMBL IDCHEMBL12
ChEBI ID49575
PubChem CID3016
DrugBankDB00829
UNII IDQ3JTX2Q7TU (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADRA1A
ADRA1A
ALB
ALB
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
148
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Q9UD67
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Diazepam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,319,608 documents
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Safety
Black-box Warning
Black-box warning for: Diazepam, Diazepam intensol, Libervant, Valium, Valtoco
Adverse Events
Top Adverse Reactions
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50,430 adverse events reported
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