Zinecard, Savene(dexrazoxane)
Dexrazoxane, Savene (dexrazoxane) is a small molecule pharmaceutical. Dexrazoxane was first approved as Zinecard on 1995-05-26. It is used to treat breast neoplasms in the USA. It has been approved in Europe to treat extravasation of diagnostic and therapeutic materials.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cardioxane | unapproved drug for use in drug shortage | 2017-07-12 |
| dexrazoxane | ANDA | 2024-05-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| breast neoplasms | EFO_0003869 | D001943 | C50 |
| extravasation of diagnostic and therapeutic materials | — | D005119 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1190 | Injection, dexrazoxane hydrochloride, per 250 mg |
Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 2 | 10 | 4 | — | 1 | 17 |
| Leukemia | D007938 | — | C95 | 5 | 3 | 6 | — | 1 | 14 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 5 | 1 | 6 | — | 1 | 12 |
| Lymphoid leukemia | D007945 | — | C91 | 4 | 1 | 6 | — | — | 10 |
| Lymphoma | D008223 | — | C85.9 | 3 | 1 | 4 | — | 1 | 9 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | — | 5 | 2 | — | — | 7 |
| Osteosarcoma | D012516 | — | — | 2 | 2 | 1 | — | 2 | 7 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | 1 | 1 | 5 | — | — | 7 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 3 | 1 | — | — | 6 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | 2 | 1 | — | 1 | 5 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 3 | 1 | — | — | 1 | 5 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 2 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 2 | — | — | — | 3 |
| Rhabdomyosarcoma | D012208 | — | — | — | 3 | — | — | — | 3 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | 1 | — | — | — | 2 |
| Preleukemia | D011289 | — | — | 1 | 1 | — | — | — | 2 |
| Blast crisis | D001752 | — | — | 1 | 1 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Adenoid cystic carcinoma | D003528 | — | — | — | 1 | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | 1 | — | — | — | 1 |
Show 15 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 3 | — | — | — | 1 | 4 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 2 | — | — | — | — | 2 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 2 | — | — | — | — | 2 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | 2 | — | — | — | — | 2 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Mycoses | D009181 | — | B35-B49 | 1 | — | — | — | — | 1 |
| Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | 1 | — | — | — | — | 1 |
Show 18 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 1 | 1 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dexrazoxane |
| INN | dexrazoxane |
| Description | (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent. |
| Classification | Small molecule |
| Drug class | alpha-adrenoceptor antagonists (benzodioxane derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 |
Identifiers
| PDB | — |
| CAS-ID | 24584-09-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1738 |
| ChEBI ID | 50223 |
| PubChem CID | 71384 |
| DrugBank | DB00380 |
| UNII ID | 048L81261F (ChemIDplus, GSRS) |
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Totect – Cumberland Pharmaceuticals
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Trends
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Additional graphs summarizing 2,560 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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1,181 adverse events reported
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