Dexketoprofen
Dexketoprofen is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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FDA approval date
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Commercial
Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| keralyt | unapproved drug other | 2024-03-27 |
| ketophene | unapproved drug other | 2016-07-21 |
| ketoprofen | ANDA | 2025-09-09 |
Indications
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Agency Specific
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE17: Dexketoprofen
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA27: Dexketoprofen
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AJ: Opioids in combination with non-opioid analgesics
— N02AJ14: Tramadol and dexketoprofen
HCPCS
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Clinical
Clinical Trials
115 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | 2 | 1 | 7 | 10 | 20 |
| Acute pain | D059787 | — | R52 | 1 | 1 | 2 | 3 | 4 | 11 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | 4 | 4 | 9 |
| Agnosia | D000377 | EFO_0007136 | F88 | — | — | — | 1 | 5 | 6 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | 4 | 2 | 6 |
| Analgesia | D000698 | — | — | — | 1 | — | 2 | 3 | 6 |
| Renal colic | D056844 | EFO_1001412 | N23 | — | — | — | 4 | 1 | 5 |
| Low back pain | D017116 | — | M54.5 | — | — | 1 | 4 | — | 5 |
| Headache | D006261 | — | R51 | — | — | — | 3 | 2 | 5 |
| Colic | D003085 | — | R10.83 | — | — | — | 3 | 1 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain management | D059408 | — | — | — | 1 | 1 | — | 5 | 6 |
| Hysteroscopy | D015907 | — | — | — | — | 1 | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 1 | — | — | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | 1 | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | — | 1 | — | — | 1 |
| Alveolar bone loss | D016301 | — | — | — | — | 1 | — | — | 1 |
| Chest pain | D002637 | — | R07.9 | — | 1 | 1 | — | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 1 | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | 1 | — | — | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Shoulder pain | D020069 | — | M25.51 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nerve block | D009407 | — | — | — | — | — | — | 4 | 4 |
| Impacted tooth | D014095 | — | K01.1 | — | — | — | — | 3 | 3 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | — | — | 2 | 2 |
| Hernia | D006547 | — | K40-K46 | — | — | — | — | 2 | 2 |
| Laparoscopic cholecystectomy | D017081 | — | — | — | — | — | — | 2 | 2 |
| Conduction anesthesia | D000765 | — | — | — | — | — | — | 2 | 2 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
| Maxillofacial injuries | D008446 | — | — | — | — | — | — | 1 | 1 |
| Maxillofacial abnormalities | D019767 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dexketoprofen |
| INN | dexketoprofen |
| Description | Dexketoprofen is a monocarboxylic acid that is (S)-hydratropic acid substituted at position 3 on the phenyl ring by a benzoyl group. A cyclooxygenase inhibitor, it is used to relieve short-term pain, such as muscular pain, dental pain and dysmenorrhoea. It has a role as a non-steroidal anti-inflammatory drug, a cyclooxygenase 1 inhibitor, a cyclooxygenase 2 inhibitor and a non-narcotic analgesic. It is a monocarboxylic acid and a member of benzophenones. It is functionally related to a (S)-hydratropic acid. |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 22161-81-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL75435 |
| ChEBI ID | 76128 |
| PubChem CID | 667550 |
| DrugBank | DB09214 |
| UNII ID | 6KD9E78X68 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 14,576 documents
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Safety
Black-box Warning
Black-box warning for: Ketoprofen
Adverse Events
Top Adverse Reactions
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924 adverse events reported
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