Desvenlafaxine
Desvenlafaxine, Pristiq (desvenlafaxine) is a small molecule pharmaceutical. Desvenlafaxine was first approved as Pristiq on 2008-02-29. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent noradrenaline transporter and sodium-dependent serotonin transporter. In addition, it is known to target sodium-dependent dopamine transporter.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Pristiq (generic drugs available since 2015-06-29, discontinued: Khedezla)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desvenlafaxine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DESVENLAFAXINE | Alembic Pharmaceuticals | N-204150 RX | 2013-03-04 | 2 products, RLD, RS |
Show 1 discontinued
Desvenlafaxine fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DESVENLAFAXINE | Sun Pharmaceutical Industries | N-205583 DISCN | 2014-01-28 | 2 products, RLD |
| DESVENLAFAXINE | Teva | N-205208 DISCN | 2013-10-11 | 2 products |
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Desvenlafaxine succinate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRISTIQ | CV Sciences | N-021992 RX | 2008-02-29 | 3 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| desvenlafaxine | ANDA | 2024-07-18 |
| desvenlafaxine er | ANDA | 2024-09-10 |
| desvenlafaxine succinate | NDA authorized generic | 2024-07-22 |
| pristiq | New Drug Application | 2024-08-23 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| major depressive disorder | EFO_0003761 | D003865 | F22 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Desvenlafaxine Succinate, Pristiq, Pf Prism Cv | |||
| 8269040 | 2027-07-05 | DP | |
HCPCS
No data
Clinical
Clinical Trials
159 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 12 | 18 | 45 | 33 | 13 | 116 |
| Depression | D003863 | — | F33.9 | 7 | 18 | 44 | 32 | 10 | 106 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 13 | 15 | 40 | 26 | 13 | 103 |
| Healthy volunteers/patients | — | — | — | 9 | — | 1 | 1 | — | 11 |
| Hot flashes | D019584 | — | — | 2 | — | 3 | 2 | 2 | 9 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | 3 | 2 | 6 |
| Dysthymic disorder | D019263 | EFO_0008623 | F34.1 | — | 1 | — | 2 | 2 | 5 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | 2 | 1 | 1 | — | 4 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | 2 | 1 | — | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 1 | 2 | 3 |
Show 17 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | — | 2 | — | — | 3 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | — | 2 | — | — | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 2 | 1 | — | — | 2 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | — | 2 | — | — | 2 |
| Sleep | D012890 | GO_0030431 | — | — | — | 1 | — | — | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 1 | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | — | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | 1 | — | — | 1 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | 1 | — | — | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | — | 3 | — | — | — | 3 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 3 | — | — | — | 3 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | 3 | — | — | — | 3 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | 1 | — | — | — | 1 |
| Insulin resistance | D007333 | HP_0000855 | — | — | 1 | — | — | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | — | 1 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 1 | — | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | 1 | — | — | — | 1 |
Show 3 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 1 | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Panic disorder | D016584 | EFO_0004262 | F41.0 | — | — | — | — | 1 | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | — | — | 1 | 1 |
| Traumatic stress disorders | D040921 | — | — | — | — | — | — | 1 | 1 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 1 | 1 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 1 | 1 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
| Adjustment disorders | D000275 | — | F43.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Desvenlafaxine |
| INN | desvenlafaxine |
| Description | O-desmethylvenlafaxine is a tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine. It has a role as a marine xenobiotic metabolite, a drug metabolite and an antidepressant. It is a member of cyclohexanols, a member of phenols and a tertiary amino compound. |
| Classification | Small molecule |
| Drug class | antianxiety, antidepressant inhibitor of norepinephrine and dopamine re-uptake |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 93413-62-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1118 |
| ChEBI ID | 83527 |
| PubChem CID | 125017 |
| DrugBank | DB06700 |
| UNII ID | NG99554ANW (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A2
SLC6A2
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A2
Gene synonyms
NAT1, NET1, SLC6A5
NCBI Gene ID
Protein name
sodium-dependent noradrenaline transporter
Protein synonyms
NET, neurotransmitter transporter, Norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, solute carrier family 6 member 5
Uniprot ID
Mouse ortholog
Slc6a2 (20538)
sodium-dependent noradrenaline transporter (Q6QU62)
Alternate
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A3
Gene synonyms
DAT1
NCBI Gene ID
Protein name
sodium-dependent dopamine transporter
Protein synonyms
DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, Solute carrier family 6 member 3
Uniprot ID
Mouse ortholog
Slc6a3 (13162)
sodium-dependent dopamine transporter (Q9R1I2)
Variants
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Financial
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Pristiq – Pfizer
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Estimated US medical usage
Desvenlafaxine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,308 documents
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Safety
Black-box Warning
Black-box warning for: Desvenlafaxine, Desvenlafaxine er, Desvenlafaxine succinate, Pristiq
Adverse Events
Top Adverse Reactions
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21,858 adverse events reported
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