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AboutPricing
Drug ReportsDesvenlafaxine
Desvenlafaxine
Desvenlafaxine, Pristiq (desvenlafaxine) is a small molecule pharmaceutical. Desvenlafaxine was first approved as Pristiq on 2008-02-29. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent noradrenaline transporter and sodium-dependent serotonin transporter. In addition, it is known to target sodium-dependent dopamine transporter.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Desvenlafaxine, Pristiq (discontinued: Desvenlafaxine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desvenlafaxine fumarate
Tradename
Company
Number
Date
Products
DESVENLAFAXINESun Pharmaceutical IndustriesN-205583 DISCN2014-01-28
2 products, RLD
DESVENLAFAXINETevaN-205208 DISCN2013-10-11
2 products
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Desvenlafaxine
Tradename
Company
Number
Date
Products
DESVENLAFAXINEAlembic PharmaceuticalsN-204150 RX2013-03-04
2 products, RLD, RS
Desvenlafaxine succinate
Tradename
Company
Number
Date
Products
PRISTIQCV SciencesN-021992 RX2008-02-29
3 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
desvenlafaxineANDA2026-04-03
desvenlafaxine erANDA2026-03-05
desvenlafaxine succinateANDA2026-04-01
pristiqNew Drug Application2026-03-31
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
major depressive disorderEFO_0003761D003865F22
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Desvenlafaxine Succinate, Pristiq, Pf Prism Cv
82690402027-07-05DP
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AX: Other antidepressants in atc
— N06AX23: Desvenlafaxine
HCPCS
No data
Clinical
Clinical Trials
165 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863—F33.9———1—1
Major depressive disorderD003865EFO_0003761F22———1—1
Depressive disorderD003866EFO_1002014F32.A———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDesvenlafaxine
INNdesvenlafaxine
Description
O-desmethylvenlafaxine is a tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine. It has a role as a marine xenobiotic metabolite, a drug metabolite and an antidepressant. It is a member of cyclohexanols, a member of phenols and a tertiary amino compound.
Classification
Small molecule
Drug classantianxiety, antidepressant inhibitor of norepinephrine and dopamine re-uptake
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CC(c1ccc(O)cc1)C1(O)CCCCC1
Identifiers
PDB—
CAS-ID93413-62-8
RxCUI—
ChEMBL IDCHEMBL1118
ChEBI ID83527
PubChem CID125017
DrugBankDB06700
UNII IDNG99554ANW (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A2
SLC6A2
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A2
Gene synonyms
NAT1, NET1, SLC6A5
NCBI Gene ID
6530
Protein name
sodium-dependent noradrenaline transporter
Protein synonyms
NET, neurotransmitter transporter, Norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, solute carrier family 6 member 5
Uniprot ID
Q96KH8
Mouse ortholog
Slc6a2 (20538)
sodium-dependent noradrenaline transporter (Q6QU62)
Alternate
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A3
Gene synonyms
DAT1
NCBI Gene ID
6531
Protein name
sodium-dependent dopamine transporter
Protein synonyms
DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, Solute carrier family 6 member 3
Uniprot ID
Q14996
Mouse ortholog
Slc6a3 (13162)
sodium-dependent dopamine transporter (Q9R1I2)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Pristiq – Pfizer
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Estimated US medical usage
Desvenlafaxine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,326 documents
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Safety
Black-box Warning
Black-box warning for: Desvenlafaxine, Desvenlafaxine succinate, Pristiq
Adverse Events
Top Adverse Reactions
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22,204 adverse events reported
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