Desoximetasone
Desoximetasone, Topicort (desoximetasone) is a small molecule pharmaceutical. Desoximetasone was first approved as Topicort on 1982-01-01. It is used to treat facial dermatoses, foot dermatoses, hand dermatoses, inflammation, and leg dermatoses amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Desoximetasone, Topicort (discontinued: Desoximetasone, Topicort)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desoximetasone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TOPICORT | Taro Pharmaceutical | N-018594 RX | 1985-01-17 | 1 products, RLD, RS |
| TOPICORT | Taro Pharmaceutical | N-204141 RX | 2013-04-11 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| desoximetasone | ANDA | 2024-12-24 |
| desoximetasone 0.05% / hydroquinone 6% / tretinoin 0.05% | unapproved drug other | 2019-05-20 |
| desoximetasone 0.05% / niacinamide 4% | unapproved drug other | 2019-05-22 |
| topicort | ANDA | 2024-12-19 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| inflammation | MP_0001845 | D007249 | — |
| facial dermatoses | — | D005148 | — |
| foot dermatoses | — | D005533 | — |
| hand dermatoses | — | D006229 | — |
| scalp dermatoses | — | D012536 | — |
| leg dermatoses | — | D007868 | — |
Agency Specific
FDA
EMA
No data
ATC Codes
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC03: Desoximetasone
— D07X: Corticosteroids, other combinations
— D07XC: Corticosteroids, potent, other combinations
— D07XC02: Desoximetasone
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 2 | 3 | 4 | — | 9 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | 1 | 1 | — | 2 |
| Eczema | D004485 | HP_0000964 | L30.9 | — | — | 1 | 1 | — | 2 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | — | — | 1 | 1 | — | 2 |
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Desoximetasone |
| INN | desoximetasone |
| Description | Desoximetasone is dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis. It has a role as an anti-inflammatory drug and an antipruritic drug. It is an 11beta-hydroxy steroid, a 21-hydroxy steroid, a glucocorticoid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a primary alpha-hydroxy ketone. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO |
Identifiers
| PDB | — |
| CAS-ID | 382-67-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1766 |
| ChEBI ID | 691037 |
| PubChem CID | 5311067 |
| DrugBank | DB00547 |
| UNII ID | 4E07GXB7AU (ChemIDplus, GSRS) |
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Estimated US medical usage
Desoximetasone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 279 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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9,776 adverse events reported
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