Desogestrel
Bekyree, Cyclessa, Desogestrel / Ethinyl Estradiol, Enskyce, Isibloom, Kalliga, Kariva, Pimtrea, Simliya, Velivet, Viorele, Volnea (desogestrel) is a small molecule pharmaceutical. Desogestrel was first approved as Desogen on 1992-12-10. It is used to treat acne vulgaris, endometriosis, and menstruation disturbances in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Combinations
Bekyree, Cyclessa, Desogestrel ethinyl estradiol, Enskyce, Isibloom, Kalliga, Kariva, Pimtrea, Simliya, Velivet, Viorele, Volnea (discontinued: Desogen, Desogestrel ethinyl estradiol, Emoquette, Kimidess, Mircette, Ortho-cept)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desogestrel
+
Ethinyl estradiol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CYCLESSA | Aspen Global | N-021090 RX | 2000-12-20 | 1 products, RLD, RS |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| apri | ANDA | 2024-06-12 |
| azurette | ANDA | 2024-06-25 |
| bekyree | ANDA | 2023-03-31 |
| caziant | ANDA | 2020-12-15 |
| cyred eq | ANDA | 2024-12-23 |
| desogestrel and ethinyl estradiol | ANDA | 2024-04-22 |
| desogestrel and ethinyl estradiol and ethinyl estradiol | ANDA | 2024-04-22 |
| enskyce | ANDA | 2024-01-11 |
| isibloom | ANDA | 2024-09-25 |
| juleber | ANDA | 2024-06-12 |
Show 9 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA09: Desogestrel and ethinylestradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB05: Desogestrel and ethinylestradiol
— G03AC: Progestogen systemic hormonal contraceptives
— G03AC09: Desogestrel
— G03F: Progestogens and estrogens in combination
— G03FB: Progestogens and estrogens, sequential preparations
— G03FB10: Desogestrel and estrogen
HCPCS
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Clinical
Clinical Trials
108 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Contraception | D003267 | — | — | 1 | 2 | 6 | 3 | 10 | 21 |
| Infertility | D007246 | EFO_0000545 | — | — | 1 | 3 | 5 | 3 | 11 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 1 | 2 | 2 | 5 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | 1 | 1 | 1 | — | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | 1 | 1 | 2 |
| Ovulation induction | D010062 | — | — | 1 | 1 | — | 1 | — | 2 |
| Bone diseases | D001847 | — | M89.9 | — | — | — | 2 | — | 2 |
| Dysmenorrhea | D004412 | — | N94.6 | — | 1 | — | 1 | — | 2 |
| Emergencies | D004630 | — | — | — | — | — | 1 | 1 | 2 |
| Postcoital contraception | D044363 | — | — | — | — | — | 1 | 1 | 2 |
Show 15 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis | D006505 | — | K75.9 | — | — | 1 | — | 4 | 5 |
| Uterine hemorrhage | D014592 | — | — | — | 2 | 1 | — | 2 | 5 |
| Hepatitis c | D006526 | — | B19.2 | — | — | 1 | — | 3 | 4 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | 1 | — | 3 | 4 |
| Healthy volunteers/patients | — | — | — | 1 | 1 | 1 | — | — | 3 |
| Syndrome | D013577 | — | — | — | 3 | 1 | — | — | 3 |
| Metrorrhagia | D008796 | — | N92.1 | — | — | 1 | — | 2 | 3 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | 1 | — | 2 | 3 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | 1 | — | 2 | 3 |
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | 1 | — | 1 | 2 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemostasis | D006487 | — | — | — | 2 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | — | — | — | 2 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | 1 | — | — | — | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | 1 | — | — | — | 2 |
| Ovarian diseases | D010049 | — | — | — | 1 | — | — | — | 1 |
| Hypoventilation | D007040 | — | — | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | — | 7 | 7 |
| Bradycardia | D001919 | — | R00.1 | — | — | — | — | 4 | 4 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 3 | 3 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | — | — | 2 | 2 |
| Contraception behavior | D003268 | — | — | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Atrioventricular block | D054537 | — | I44.3 | — | — | — | — | 2 | 2 |
| Bundle-branch block | D002037 | EFO_0004138 | I44.7 | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
Show 42 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Desogestrel |
| INN | desogestrel |
| Description | Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive. |
| Classification | Small molecule |
| Drug class | estrogens; progestins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC |
Identifiers
| PDB | — |
| CAS-ID | 54024-22-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1533 |
| ChEBI ID | 4453 |
| PubChem CID | 40973 |
| DrugBank | DB00304 |
| UNII ID | 81K9V7M3A3 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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Estimated US medical usage
Desogestrel
+
Ethinyl estradiol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Additional graphs summarizing 1,884 documents
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Safety
Black-box Warning
Black-box warning for: Azurette, Bekyree, Cyred eq, Desogestrel and ethinyl estradiol, Enskyce, Isibloom, Juleber, Kalliga, Kariva, Simliya, Viorele
Adverse Events
Top Adverse Reactions
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3,139 adverse events reported
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