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Drug ReportsDesmopressin
Desmopressin
Ddavp, Desmopressin (desmopressin) is a protein pharmaceutical. Desmopressin was first approved as Ddavp on 1982-01-01. It is used to treat enuresis, hemorrhage, neurogenic diabetes insipidus, thrombocytopenia, and von willebrand diseases in the USA. It is known to target vasopressin V1b receptor, vasopressin V2 receptor, vasopressin V1a receptor, and oxytocin receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
mental disordersD001523
Trade Name
FDA
EMA
Ddavp, Desmopressin (discontinued: Concentraid, Ddavp, Desmopressin, Minirin, Nocdurna, Noctiva, Stimate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desmopressin acetate
Tradename
Company
Number
Date
Products
DDAVPFerring PharmaceuticalsN-018938 RX1984-03-30
1 products, RLD, RS
DDAVPFerring PharmaceuticalsN-019955 RX1995-09-06
2 products, RLD, RS
Show 10 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ddavpNew Drug Application2022-09-28
desmopressin acetateANDA2025-02-19
nocdurnaNew Drug Application2023-10-19
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hemorrhageMP_0001914D006470R58
thrombocytopeniaHP_0001873D013921D69.6
von willebrand diseasesEFO_0003910D014842D68.0
neurogenic diabetes insipidus—D020790—
enuresis—D004775R32
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Desmopressin Acetate, Noctiva, Acerus Pharms
95393022030-06-15DP
114199142030-06-15U-3431
77997612024-09-26DP
Desmopressin Acetate, Nocdurna, Ferring Pharms Inc
99748262030-04-13U-2326, U-2327
101371672029-05-21U-2327
110204482029-05-21U-2327
75604292024-02-02DPU-2326
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BA: Vasopressin and analogues
— H01BA02: Desmopressin
HCPCS
Code
Description
J2597
Injection, desmopressin acetate, per 1 mcg
Clinical
Clinical Trials
120 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nocturnal enuresisD053206—N39.44——2327
EnuresisD004775—R32——2327
Urinary incontinenceD014549—R32——2316
Aortic valve stenosisD001024EFO_0000266————1—1
Pathologic constrictionD003251—————1—1
Von willebrand diseasesD014842EFO_0003910D68.0———1—1
Eye diseasesD005128EFO_0003966H44———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NocturiaD053158—R35.1—68—822
PolyuriaD011141—R35—13—26
Diabetes insipidusD003919—E23.2——1——1
Neurogenic diabetes insipidusD020790————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Overactive urinary bladderD053201EFO_1000781N32.81—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug-related side effects and adverse reactionsD064420—T88.7————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDesmopressin
INNdesmopressin
Description
Desmopressin is a synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function. It has a role as a vasopressin receptor agonist, a renal agent and a diagnostic agent.
Classification
Protein
Drug classvasoconstrictors (vasopressin derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
Identifiers
PDB—
CAS-ID16679-58-6
RxCUI—
ChEMBL IDCHEMBL1429
ChEBI ID4450
PubChem CID5311065
DrugBankDB00035
UNII IDENR1LLB0FP (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
AVPR1B
AVPR1B
AVPR2
AVPR2
AVPR1A
AVPR1A
OXTR
OXTR
Organism
Homo sapiens
Gene name
AVPR1B
Gene synonyms
AVPR3, VPR3
NCBI Gene ID
553
Protein name
vasopressin V1b receptor
Protein synonyms
Antidiuretic hormone receptor 1b, arginine vasopressin receptor 3, AVPR V1b, AVPR V3, pituitary vasopressin receptor 3, V1B receptor, Vasopressin V3 receptor
Uniprot ID
Q5TZ00
Mouse ortholog
Avpr1b (26361)
vasopressin V1b receptor (Q9WU02)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Noctiva – Avadel Pharmaceuticals
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Estimated US medical usage
Desmopressin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,704 documents
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Safety
Black-box Warning
Black-box warning for: Ddavp, Desmopressin acetate, Nocdurna
Adverse Events
Top Adverse Reactions
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4,316 adverse events reported
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