Deserpidine - PharmaKB

Deserpidine

Enduronyl, Harmonyl, Oreticyl (deserpidine) is a small molecule pharmaceutical. Deserpidine was first approved as Harmonyl on 1982-01-01. It is used to treat dyskinesias, hypertension, and schizophrenia in the USA.

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Therapeutic Areas

Therapeutic Area	MeSH
nervous system diseases	D009422
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568
mental disorders	D001523

Trade Name

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Drug Products

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New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Deserpidine

Tradename	Company	Number	Date	Products
HARMONYL	AbbVie	N-010796 DISCN	1982-01-01	2 products

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Deserpidine

Hydrochlorothiazide

Tradename	Company	Number	Date	Products
ORETICYL 25	AbbVie	N-012148 DISCN	1982-01-01	1 products
ORETICYL FORTE	AbbVie	N-012148 DISCN	1982-01-01	1 products
ORETICYL 50	AbbVie	N-012148 DISCN	1982-01-01	1 products

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Deserpidine

Methyclothiazide

Tradename	Company	Number	Date	Products
ENDURONYL	Abbott Biotherapeutics	N-012775 DISCN	1982-01-01	1 products
ENDURONYL FORTE	Abbott Biotherapeutics	N-012775 DISCN	1982-01-01	1 products

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Indications

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EMA

Indication	Ontology	MeSH	ICD-10
hypertension	EFO_0000537	D006973	I10
dyskinesias	—	D020820	G24
schizophrenia	EFO_0000692	D012559	F20
heart failure	EFO_0003144	D006333	I50
nephrotic syndrome	EFO_0004255	D009404	N04
edema	—	D004487	R60.9
glomerulonephritis	—	D005921	N05
liver cirrhosis	EFO_0001422	D008103	K74.0

Agency Specific

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Patent Expiration

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ATC Codes

C: Cardiovascular system drugs

— C02: Antihypertensives

— C02A: Antiadrenergic agents, centrally acting

— C02AA: Rauwolfia alkaloids, centrally acting antiadrenergic

— C02AA05: Deserpidine

— C02L: Antihypertensives and diuretics in combination

— C02LA: Rauwolfia alkaloids and diuretics in combination

— C02LA03: Deserpidine and diuretics

HCPCS

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Clinical

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Drug

General

Drug common name	Deserpidine
INN	deserpidine
Description	Deserpidine is an alkaloid ester, a methyl ester, a benzoate ester, an organic heteropentacyclic compound and a yohimban alkaloid. It derives from a hydride of a yohimban.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC

Identifiers

PDB	—
CAS-ID	131-01-1
RxCUI	—
ChEMBL ID	CHEMBL1200515
ChEBI ID	27478
PubChem CID	8550
DrugBank	DB01089
UNII ID	9016E3VB47 (ChemIDplus, GSRS)

Target

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Financial

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Estimated US medical usage

Deserpidine

Methyclothiazide

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Safety

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Adverse Events

0 adverse events reported