Denenicokin
Denenicokin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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Commercial
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Clinical
Clinical Trials
48 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 2 | 2 | 1 | — | — | 4 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 3 | — | 1 | — | — | 4 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | 1 | — | — | 3 |
| Follicular lymphoma | D008224 | — | C82 | — | — | 1 | — | — | 1 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | — | 1 | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | — | 1 | — | — | 1 |
| Plasmablastic lymphoma | D000069293 | — | C83.3 | — | — | 1 | — | — | 1 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 4 | 7 | — | — | — | 10 |
| Neoplasms | D009369 | — | C80 | 4 | 5 | — | — | 1 | 10 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 7 | 4 | — | — | — | 7 |
| Leukemia | D007938 | — | C95 | 6 | 3 | — | — | — | 6 |
| Myeloid leukemia | D007951 | — | C92 | 5 | 3 | — | — | — | 5 |
| Carcinoma | D002277 | — | C80.0 | 1 | 4 | — | — | — | 4 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 2 | — | — | — | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 2 | — | — | — | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 3 | — | — | — | 3 |
| Transitional cell carcinoma | D002295 | — | — | — | 2 | — | — | — | 2 |
Show 17 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | — | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Rhabdoid tumor | D018335 | — | — | 2 | — | — | — | — | 2 |
| Liposarcoma | D008080 | — | — | 2 | — | — | — | — | 2 |
| Rhabdomyosarcoma | D012208 | — | — | 2 | — | — | — | — | 2 |
| Wilms tumor | D009396 | EFO_0000212 | — | 2 | — | — | — | — | 2 |
| Endodermal sinus tumor | D018240 | — | — | 2 | — | — | — | — | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | — | — | — | — | 2 |
| Hepatoblastoma | D018197 | — | C22.2 | 2 | — | — | — | — | 2 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | 1 | 2 |
Show 13 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pemphigus | D010392 | EFO_1000749 | L10 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 1 | 1 |
| Gingivitis | D005891 | — | K05.10 | — | — | — | — | 1 | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | — | 1 | 1 |
| Intestinal diseases | D007410 | — | K63.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Denenicokin |
| INN | denenicokin |
| Description | Denenicokin is a protein pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Protein |
| Drug class | interleukins: interleukin-21 |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107855 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | A4LY1V9F0H (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
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Adverse Events
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84 adverse events reported
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