Demeclocycline
Demeclocycline (demeclocycline) is a small molecule pharmaceutical. Demeclocycline was first approved as Declomycin on 1982-01-01. It is used to treat acne vulgaris, actinomycosis, bacterial infections, campylobacter infections, and cholera amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Demeclocycline (discontinued: Declomycin, Demeclocycline)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Demeclocycline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DECLOMYCIN | CorePharma | N-050261 DISCN | 1982-01-01 | 3 products |
| DECLOMYCIN | Lederle Laboratories | N-050257 DISCN | 1982-01-01 | 1 products |
| DECLOMYCIN | Lederle Laboratories | N-050262 DISCN | 1982-01-01 | 1 products |
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| demeclocycline hydrochloride | ANDA | 2024-12-19 |
Indications
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Agency Specific
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Patent Expiration
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ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06A: Antibiotics for topical use
— D06AA: Tetracycline and derivatives, topical antibiotics
— D06AA01: Demeclocycline
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01A: Tetracycline antibiotics
— J01AA: Tetracyclines
— J01AA01: Demeclocycline
HCPCS
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | — | 2 | — | 2 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental implants | D015921 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Demeclocycline |
| INN | demeclocycline |
| Description | Demeclocycline is tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood levels are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It has a role as an antibacterial drug, a geroprotector and an aquaretic. |
| Classification | Small molecule |
| Drug class | antibiotics (tetracycline derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 127-33-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1591 |
| ChEBI ID | 4392 |
| PubChem CID | 54680690 |
| DrugBank | DB00618 |
| UNII ID | 5R5W9ICI6O (ChemIDplus, GSRS) |
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Estimated US medical usage
Demeclocycline
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Trends
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Safety
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Adverse Events
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99 adverse events reported
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