Deferoxamine
Deferoxamine, Desferal (deferoxamine) is a small molecule pharmaceutical. Deferoxamine was first approved as Desferal on 1982-01-01. It is used to treat bone diseases, corneal diseases, and hemochromatosis in the USA.
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Commercial
Trade Name
FDA
EMA
Deferoxamine, Desferal (discontinued: Deferoxamine, Desferal)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| deferoxamine | ANDA | 2024-04-03 |
| deferoxamine mesylate | ANDA | 2024-09-24 |
| desferal | New Drug Application | 2024-07-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bone diseases | — | D001847 | M89.9 |
| corneal diseases | — | D003316 | H18.9 |
| hemochromatosis | EFO_1000642 | D006432 | E83.11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0895 | Injection, deferoxamine mesylate, 500 mg |
Clinical
Clinical Trials
79 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thalassemia | D013789 | EFO_1001996 | D56 | 2 | 13 | 6 | 5 | 7 | 28 |
| Iron overload | D019190 | — | — | 1 | 15 | 5 | 3 | 5 | 25 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | 1 | 9 | 5 | 5 | 4 | 21 |
| Hemochromatosis | D006432 | EFO_1000642 | E83.11 | — | 4 | 3 | 2 | 1 | 9 |
| Hemosiderosis | D006486 | — | — | — | 4 | 3 | 2 | 1 | 9 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 5 | 1 | 3 | — | 8 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 3 | — | 2 | 1 | 6 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | 1 | 2 | 4 |
| Covid-19 | D000086382 | — | — | 1 | 1 | 1 | 1 | — | 3 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 4 | 5 | 1 | — | — | 8 |
| Cerebral hemorrhage | D002543 | — | — | 2 | 3 | 1 | — | — | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | 2 | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | 1 | — | — | 2 |
| Oxidative stress | D018384 | EFO_1001905 | — | — | 1 | 1 | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | — | 1 | — | — | 1 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 4 | 1 | — | — | — | 4 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 2 | — | — | 2 | 4 |
| Preleukemia | D011289 | — | — | — | 1 | — | — | 2 | 3 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | 2 | — | — | 1 | 3 |
| Ischemia | D007511 | EFO_0000556 | — | 2 | 1 | — | — | — | 3 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 2 | 2 | — | — | — | 3 |
| Syndrome | D013577 | — | — | — | 1 | — | — | 1 | 2 |
| Ulcer | D014456 | MPATH_579 | — | 1 | 2 | — | — | — | 2 |
| Ischemic stroke | D000083242 | — | — | — | 1 | — | — | 1 | 2 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | 2 | — | — | — | 2 |
Show 26 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
| Cerebral infarction | D002544 | — | I63 | 1 | — | — | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | — | 1 |
| Meningeal carcinomatosis | D055756 | EFO_1001012 | — | 1 | — | — | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | — | — | — | — | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | 1 | — | — | — | — | 1 |
| Reperfusion injury | D015427 | — | — | 1 | — | — | — | — | 1 |
Show 16 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 1 | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | — | 1 | 1 |
| Chelation therapy | D015913 | — | — | — | — | — | — | 1 | 1 |
| Leukemia | D007938 | — | C95 | — | — | — | — | 1 | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | — | — | — | 1 | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Deferoxamine |
| INN | deferoxamine |
| Description | Deferoxamine (DFOA), also known as desferrioxamine and sold under the brand name Desferal, is a medication that binds iron and aluminium. It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis. It is used by injection into a muscle, vein, or under the skin.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN |
Identifiers
| PDB | — |
| CAS-ID | 70-51-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL556 |
| ChEBI ID | 4356 |
| PubChem CID | 2973 |
| DrugBank | DB00746 |
| UNII ID | J06Y7MXW4D (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Deferoxamine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 20,679 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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1,692 adverse events reported
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