Deferoxamine
Deferoxamine, Desferal (deferoxamine) is a small molecule pharmaceutical. Deferoxamine was first approved as Desferal on 1982-01-01. It is used to treat bone diseases, corneal diseases, and hemochromatosis in the USA.
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Commercial
Trade Name
FDA
EMA
Desferal (generic drugs available since 2004-03-17)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| deferoxamine | ANDA | 2024-04-03 |
| deferoxamine mesylate | ANDA | 2024-09-24 |
| desferal | New Drug Application | 2024-07-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bone diseases | — | D001847 | M89.9 |
| corneal diseases | — | D003316 | H18.9 |
| hemochromatosis | EFO_1000642 | D006432 | E83.11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0895 | Injection, deferoxamine mesylate, 500 mg |
Clinical
Clinical Trials
75 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thalassemia | D013789 | EFO_1001996 | D56 | 2 | 13 | 6 | 5 | 7 | 28 |
| Iron overload | D019190 | — | — | 1 | 15 | 5 | 3 | 5 | 25 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | 1 | 9 | 5 | 5 | 4 | 21 |
| Hemochromatosis | D006432 | EFO_1000642 | E83.11 | — | 4 | 3 | 2 | 1 | 9 |
| Hemosiderosis | D006486 | — | — | — | 4 | 3 | 2 | 1 | 9 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 5 | 1 | 3 | — | 8 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 3 | — | 2 | 1 | 6 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | 1 | 2 | 4 |
| Covid-19 | D000086382 | — | — | 1 | 1 | 1 | 1 | — | 3 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Oxidative stress | D018384 | EFO_1001905 | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 4 | 5 | — | — | — | 7 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 2 | — | — | 2 | 4 |
| Cerebral hemorrhage | D002543 | — | — | 2 | 3 | — | — | — | 4 |
| Neoplasms | D009369 | — | C80 | 3 | 1 | — | — | — | 3 |
| Preleukemia | D011289 | — | — | — | 1 | — | — | 2 | 3 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | 2 | — | — | 1 | 3 |
| Ischemia | D007511 | EFO_0000556 | — | 2 | 1 | — | — | — | 3 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 2 | 2 | — | — | — | 3 |
| Syndrome | D013577 | — | — | — | 1 | — | — | 1 | 2 |
| Ulcer | D014456 | MPATH_579 | — | 1 | 2 | — | — | — | 2 |
Show 29 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | — | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
| Cerebral infarction | D002544 | — | I63 | 1 | — | — | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | — | 1 |
| Meningeal carcinomatosis | D055756 | EFO_1001012 | — | 1 | — | — | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | — | — | — | — | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 1 | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | — | 1 | 1 |
| Chelation therapy | D015913 | — | — | — | — | — | — | 1 | 1 |
| Leukemia | D007938 | — | C95 | — | — | — | — | 1 | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | — | — | — | 1 | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Deferoxamine |
| INN | deferoxamine |
| Description | Deferoxamine (DFOA), also known as desferrioxamine and sold under the brand name Desferal, is a medication that binds iron and aluminium. It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis. It is used by injection into a muscle, vein, or under the skin.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN |
Identifiers
| PDB | — |
| CAS-ID | 70-51-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL556 |
| ChEBI ID | 4356 |
| PubChem CID | 2973 |
| DrugBank | DB00746 |
| UNII ID | J06Y7MXW4D (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Deferoxamine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,101 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,652 adverse events reported
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