Deferiprone - PharmaKB

Ferriprox(deferiprone)

Deferiprone, Ferriprox (deferiprone) is a small molecule pharmaceutical. Deferiprone was first approved as Ferriprox on 1999-08-25. It is used to treat iron overload in the USA. It has been approved in Europe to treat beta-thalassemia and iron overload.

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
hemic and lymphatic diseases	D006425
hereditary congenital and neonatal diseases and abnormalities	D009358
nutritional and metabolic diseases	D009750

Trade Name

FDA

EMA

Deferiprone, Ferriprox (discontinued: Ferriprox)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Deferiprone

Tradename	Company	Number	Date	Products
FERRIPROX	Chiesi Farmaceutici	N-021825 RX	2019-07-25	1 products, RLD
FERRIPROX	Chiesi Farmaceutici	N-208030 RX	2015-09-09	1 products, RLD, RS
FERRIPROX	Chiesi Farmaceutici	N-212269 RX	2020-05-19	1 products, RLD, RS

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Labels

FDA

EMA

Brand Name	Status	Last Update
deferiprone	ANDA	2025-12-15
ferriprox	New Drug Application	2026-01-28

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
iron overload	—	D019190	—

Agency Specific

FDA

EMA

Expiration	Code
DEFERIPRONE, FERRIPROX, CHIESI
2028-04-30	ODE-417, ODE-418, ODE-419, ODE-420, ODE-421
2024-04-30	I-859

Patent Expiration

Patent	Expires	Flag	FDA Information
Deferiprone, Ferriprox, Chiesi
10780055	2038-10-25	DP	U-3083
10940115	2038-10-25	DP	U-3083
10940116	2038-10-25	DP
11357731	2038-10-25		U-3083
11458103	2038-10-25	DP
11723874	2038-10-25		U-3083
8703156	2029-10-26	DP	U-3083

ATC Codes

V: Various drug classes in atc

— V03: All other therapeutic products

— V03A: All other therapeutic products

— V03AC: Iron chelating agents

— V03AC02: Deferiprone

HCPCS

No data

Clinical

Clinical Trials

2805 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Non-small-cell lung carcinoma	D002289	—	—	183	320	133	5	98	642
Neoplasms	D009369	—	C80	294	204	14	3	43	438
Lung neoplasms	D008175	—	C34.90	83	135	36	1	63	277
Carcinoma	D002277	—	C80.0	57	126	23	1	39	210
Melanoma	D008545	—	—	95	89	8	3	19	169
Squamous cell carcinoma of head and neck	D000077195	—	—	55	93	20	1	13	149
Hepatocellular carcinoma	D006528	—	C22.0	37	62	12	2	34	130
Liver neoplasms	D008113	EFO_1001513	C22.0	29	46	13	1	31	110
Uterine cervical neoplasms	D002583	—	—	27	40	21	6	14	94
Small cell lung carcinoma	D055752	—	—	34	52	9	1	11	92

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Breast neoplasms	D001943	EFO_0003869	C50	59	76	18	—	19	145
Triple negative breast neoplasms	D064726	—	—	45	61	20	—	4	109
Neoplasm metastasis	D009362	EFO_0009708	—	61	56	15	—	5	108
Colorectal neoplasms	D015179	—	—	50	51	6	—	9	98
Renal cell carcinoma	D002292	EFO_0000376	—	46	51	15	—	7	97
Stomach neoplasms	D013274	EFO_0003897	C16	30	51	16	—	16	89
Squamous cell carcinoma	D002294	—	—	28	49	8	—	10	77
Head and neck neoplasms	D006258	—	—	33	41	11	—	8	71
Pancreatic neoplasms	D010190	EFO_0003860	C25	36	41	1	—	3	61
Adenocarcinoma	D000230	—	—	16	42	8	—	5	59

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Sarcoma	D012509	—	—	13	20	—	—	2	27
Wounds and injuries	D014947	—	T14.8	—	1	—	—	14	15
Syndrome	D013577	—	—	4	7	—	—	3	14
Cutaneous malignant melanoma	D000096142	—	—	9	6	—	—	—	12
Neuroendocrine tumors	D018358	EFO_1001901	D3A.8	3	8	—	—	2	11
Gastrointestinal neoplasms	D005770	—	C26.9	4	4	—	—	4	10
Neoadjuvant therapy	D020360	—	—	1	5	—	—	3	9
Skin neoplasms	D012878	EFO_0004198	C44	6	4	—	—	1	9
T-cell lymphoma	D016399	—	—	5	6	—	—	1	9
Myelodysplastic syndromes	D009190	—	D46	5	4	—	—	—	9

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Inflammation	D007249	MP_0001845	—	1	—	—	—	4	5
Inflammatory bowel diseases	D015212	EFO_0003767	—	1	—	—	—	4	5
Bites and stings	D001733	—	—	3	—	—	—	1	4
Neuroblastoma	D009447	EFO_0000621	—	1	—	—	—	3	4
Rheumatoid arthritis	D001172	EFO_0000685	M06.9	1	—	—	—	2	3
Ureteral neoplasms	D014516	EFO_0003844	C66	2	—	—	—	—	2
Chordoma	D002817	EFO_0000334	—	1	—	—	—	1	2
Acute disease	D000208	—	—	1	—	—	—	1	2
Systemic scleroderma	D012595	EFO_0000717	M34	1	—	—	—	1	2
Psoriatic arthritis	D015535	EFO_0003778	L40.5	1	—	—	—	1	2

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Spinal cord injuries	D013119	EFO_1001919	—	—	—	—	—	13	13
Pain	D010146	EFO_0003843	R52	—	—	—	—	10	10
Osteoporosis	D010024	EFO_0003882	M81.0	—	—	—	—	10	10
Traumatic brain injuries	D000070642	—	S06	—	—	—	—	10	10
Brain injuries	D001930	—	S06.9	—	—	—	—	7	7
Hernia	D006547	—	K40-K46	—	—	—	—	6	6
Brain concussion	D001924	—	S06.0	—	—	—	—	5	5
Orthostatic hypotension	D007024	—	I95.1	—	—	—	—	5	5
Inguinal hernia	D006552	HP_0000023	K40	—	—	—	—	4	4
Intervertebral disc displacement	D007405	EFO_1001800	—	—	—	—	—	4	4

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Deferiprone
INN	deferiprone
Description	Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	Cc1c(O)c(=O)ccn1C