Ferriprox(deferiprone)
Deferiprone, Ferriprox (deferiprone) is a small molecule pharmaceutical. Deferiprone was first approved as Ferriprox on 1999-08-25. It is used to treat iron overload in the USA. It has been approved in Europe to treat beta-thalassemia and iron overload.
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Commercial
Therapeutic Areas
Trade Name
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Deferiprone, Ferriprox (discontinued: Ferriprox)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Deferiprone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FERRIPROX | Chiesi Farmaceutici | N-021825 RX | 2011-10-14 | 2 products, RLD |
| FERRIPROX | Chiesi Farmaceutici | N-208030 RX | 2015-09-09 | 1 products, RLD, RS |
| FERRIPROX | Chiesi Farmaceutici | N-212269 RX | 2020-05-19 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| OTC monograph not final | 2012-12-06 | |
| artistry exact fit longwearing foundation shade buff | C200263 | 2023-10-21 |
| artistry exact fit longwearing foundation shade chablis | C200263 | 2023-10-21 |
| artistry exact fit longwearing foundation shade cream | C200263 | 2023-10-21 |
| artistry hydra v sheer weightless foundation shade buff | C200263 | 2023-10-22 |
| artistry hydra v sheer weightless foundation shade chablis | C200263 | 2023-10-22 |
| artistry youth xtend lifting smoothing foundation shade buff | C200263 | 2023-10-22 |
| artistry youth xtend lifting smoothing foundation shade chablis | C200263 | 2023-10-22 |
| artistry youth xtend lifting smoothing foundation shade cream | C200263 | 2023-10-22 |
| deferiprone | ANDA | 2024-05-07 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| iron overload | — | D019190 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
DEFERIPRONE, FERRIPROX, CHIESI | |||
| 2028-04-30 | ODE-417, ODE-418, ODE-419, ODE-420, ODE-421 | ||
| 2024-04-30 | I-859 | ||
HCPCS
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Clinical
Clinical Trials
2296 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 152 | 249 | 120 | 3 | 69 | 515 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 108 | 197 | 105 | 1 | 54 | 410 |
| Neoplasms | D009369 | — | C80 | 263 | 170 | 9 | 3 | 35 | 374 |
| Carcinoma | D002277 | — | C80.0 | 99 | 201 | 60 | 3 | 42 | 351 |
| Melanoma | D008545 | — | — | 82 | 79 | 9 | 2 | 17 | 149 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 44 | 73 | 16 | 1 | 11 | 120 |
| Squamous cell carcinoma | D002294 | — | — | 31 | 73 | 19 | 1 | 12 | 115 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 34 | 48 | 12 | 2 | 28 | 109 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 23 | 34 | 15 | 4 | 10 | 75 |
| Papillomavirus infections | D030361 | — | — | 4 | 13 | 37 | 3 | 5 | 61 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 57 | 70 | 24 | — | 13 | 140 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 29 | 40 | 12 | — | 28 | 98 |
| Triple negative breast neoplasms | D064726 | — | — | 37 | 45 | 17 | — | 4 | 89 |
| Colorectal neoplasms | D015179 | — | — | 42 | 41 | 6 | — | 7 | 81 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 38 | 43 | 13 | — | 5 | 80 |
| Lymphoma | D008223 | — | C85.9 | 39 | 43 | 6 | — | 3 | 76 |
| Adenocarcinoma | D000230 | — | — | 20 | 47 | 16 | — | 6 | 74 |
| Small cell lung carcinoma | D055752 | — | — | 23 | 36 | 10 | — | 9 | 70 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 22 | 39 | 12 | — | 13 | 67 |
| Head and neck neoplasms | D006258 | — | — | 31 | 36 | 7 | — | 3 | 58 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 14 | 20 | — | — | 1 | 28 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 10 | 9 | — | — | — | 16 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | 14 | 15 |
| Rectal neoplasms | D012004 | — | — | 3 | 11 | — | — | 2 | 14 |
| Syndrome | D013577 | — | — | 4 | 7 | — | — | 3 | 14 |
| Healthy volunteers/patients | — | — | — | 9 | 1 | — | — | 5 | 14 |
| Cutaneous malignant melanoma | D000096142 | — | — | 7 | 9 | — | — | — | 13 |
| Pancreatic ductal carcinoma | D021441 | — | — | 5 | 6 | — | — | 1 | 11 |
| T-cell lymphoma | D016399 | — | — | 5 | 7 | — | — | 1 | 10 |
| Myelodysplastic syndromes | D009190 | — | D46 | 6 | 4 | — | — | — | 10 |
Show 138 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 4 | 5 |
| Ureteral neoplasms | D014516 | EFO_0003844 | C66 | 4 | — | — | — | — | 4 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 2 | — | — | — | 2 | 4 |
| Pleural effusion | D010996 | HP_0002202 | J90 | 1 | — | — | — | 2 | 3 |
| Bone marrow diseases | D001855 | — | — | 1 | — | — | — | 1 | 2 |
| Pelvic neoplasms | D010386 | — | — | 2 | — | — | — | — | 2 |
| Chordoma | D002817 | EFO_0000334 | — | 1 | — | — | — | 1 | 2 |
| Ascites | D001201 | HP_0001541 | R18 | 1 | — | — | — | 1 | 2 |
| Malignant pleural effusion | D016066 | — | J91.0 | 1 | — | — | — | 1 | 2 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | 1 | 2 |
Show 30 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 9 | 9 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | — | — | — | 8 | 8 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 8 | 8 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | — | — | 8 | 8 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | — | 7 | 7 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 7 | 7 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | — | — | 4 | 4 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 4 | 4 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 4 | 4 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | — | — | — | — | 4 | 4 |
Show 198 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Deferiprone |
| INN | deferiprone |
| Description | Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(O)c(=O)ccn1C |
Identifiers
| PDB | — |
| CAS-ID | 30652-11-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL70927 |
| ChEBI ID | 68554 |
| PubChem CID | 2972 |
| DrugBank | DB08826 |
| UNII ID | 2BTY8KH53L (ChemIDplus, GSRS) |
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Trends
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Safety
Black-box Warning
Black-box warning for: Deferiprone, Ferriprox
Adverse Events
Top Adverse Reactions
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9,078 adverse events reported
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